پیوندهای مفید
آمار
| تعداد نشریات | 20 |
| تعداد شماره‌ها | 1,092 |
| تعداد مقالات | 10,022 |
| تعداد مشاهده مقاله | 27,197,465 |
| تعداد دریافت فایل اصل مقاله | 7,462,283 |
Comparative Analysis of the Histopathologic Features, β-Catenin, and Ki67 Expression between Fibromatosis and Fibrosarcoma | ||
| Journal of Dentistry | ||
| مقاله 5، دوره 20، شماره 4 - شماره پیاپی 65، اسفند 2019، صفحه 255-263 اصل مقاله (971.52 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.30476/dentjods.2019.44900 | ||
| نویسندگان | ||
| Parviz Deyhimi* 1؛ Mahmoud Reza Arefian2؛ Parvin Mahzouni3 | ||
| 1Dept. of Oral and Maxillofacial Pathology, Torabinejad Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran. | ||
| 2Postgraduate Student Dept. of Oral and Maxillofacial Pathology, Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran. | ||
| 3Dept. of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. | ||
| چکیده | ||
| Statement of the Problem: The biologic behavior and histopathological features of fibromatosis are intermediate between those of fibroma and fibrosarcoma. Purpose: The aim of the present study was to determine useful histopathologic and immunohistochemical characteristics for the differentiation of these lesions. Materials and Method: In this cross-sectional descriptive study, 40 specimens comprising 20 fibrosarcoma and 20 fibromatosis biopsies were selected. The histopathologic characteristics of these lesions were identified and immunohistochemical staining for Ki67 and β-catenin markers was performed. Sections were examined by light microscopy and positively stained cells were counted. Results were analyzed by SPSS 20 using Chi-square test, Mann-whitney test, and t-test (p < 0.05). Results: Statistical significant differences were observed between fibromatosis and fibrosarcoma in terms of distribution frequency, mitotic rate, herringbone pattern, cellularity, overlapping of nuclei, mean Ki67 score, and atypia rate. The other features including age, gender, necrosis, clarity of nucleoli and mean β-catenin were not significantly different. Conclusion: The present findings suggest the mitotic figures, Ki67, herringbone pattern, cellularity, and atypia are useful to differentiate fibromatosis from fibrosarcoma. | ||
| کلیدواژه‌ها | ||
| Fibrosarcoma ● Fibromatosis ● Histopathology ● β؛ catenin ● Ki؛ 67 | ||
| مراجع | ||
|
1. Neville BW, Damm DD, Allen CM. Oral and Maxillofacial Pathology. 4th ed. Saint Louis: Elsevier; 2016. pp. 481–482, 516-517. [Google Scholar]
2. Sharon SW, Goldblum JR, editors . In: Enzinger& Weiss’s Soft tissue tumors. 5th ed. Philadelphia: Mosby Elsevier; 2008. pp. 227–228, 304. [Google Scholar]
3. Regezi JA, Sciubba JJ, Jordan RC. Oral pathology: clinical pathologic correlations. 7th ed. St Louis : Elsevier; 2017. pp. 169–171. [Google Scholar]
4. Rosai J, editor . In: Rosai and Ackerman's Surgical Pathology. 10th ed. Philadelphia: Mosby Elsevier; 2011. pp. 47, 65, 2116–2120. [Google Scholar]
5. Stout AP. Juvenile fibromatoses. Cancer. 1954; 7: 953–978. [PubMed] [Google Scholar]
6. Seper L, Hoppe P, Kruse-Lösler B, Büchter A, Joos U, Kleinheinz J. Aggressive fibromatosis in the jaw and facial region with bone involvement. A review. Mund Kiefer Gesichtschir. 2005; 9: 349–362. [PubMed] [Google Scholar]
7. Angiero F, Benedicenti S, Stefani M. Fibromatosis of the head and neck: morphological, immunohistochemical and clinical features. Anticancer Res. 2008; 28(3B): 1725–1732. [PubMed] [Google Scholar]
8. Lü D, Yue L, Li D, Zeng H, Yang H. Aggressive fibromatosis of the head and neck (A report of two cases and literature review) Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012; 26: 107–109. [PubMed] [Google Scholar]
9. Liu Y, Guan GF, Jin CS, Yang JP. Aggressive fibromatosis of the larynx: case report and brief review. J Int Med Res. 2011; 39: 682–689. [PubMed] [Google Scholar]
10. Abikhzer G, Bouganim N, Finesilver A. Aggressive fibromatosis of the head and neck: case report and review of the literature. J Otolaryngol. 2005; 34: 289–294. [PubMed] [Google Scholar]
11. Owens CL, Sharma R, Ali SZ. Deep fibromatosis (desmoid tumor): cytopathologic characteristics, clinicoradiologic features, and immunohistochemical findings on fine needle aspiration. Cancer. 2007; 111: 166–172. [PubMed] [Google Scholar]
12. Seper L, Bürger H, Vormoor J, Joos U, Kleinheinz J. Agressive fibromatosis involving the mandible--case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005; 99: 30–38. [PubMed] [Google Scholar]
13. Ferenc T, Wroński JW, Kopczyński J, Kulig A, Sidor M, Stalińska L, et al. Analysis of APC, alpha-, beta-catenins, and N-cadherin protein expression in aggressive fibromatosis (desmoid tumor) Pathol Res Pract. 2009; 205: 311–324. [PubMed] [Google Scholar]
14. Bo N, Wang D, Wu B, Chen L, Ruixue Ma. Analysis of β-catenin expression and exon 3 mutations in pediatric sporadic aggressive fibromatosis. Pediatr Dev Pathol. 2012; 15: 173–178. [PubMed] [Google Scholar]
15. Lips DJ, Barker N, Clevers H, Hennipman A. The role of APC and beta-catenin in the aetiology of aggressive fibromatosis (desmoid tumors) Eur J Surg Oncol. 2009; 35: 3–10. [PubMed] [Google Scholar]
16. Folpe AL. Fibrosarcoma: a review and update. Histopathology. 2014;64:12–25. [PubMed] [Google Scholar]
17. Soares AB, Lins LH, Macedo AP, Pereira-Neto JS, Vargas PA. Fibrosarcoma originating in the mandible. Med Oral Patol Oral Cir Bucal. 2006; 11: E243–E246. [PubMed] [Google Scholar]
18. Wadhwan V, Chaudhary MS, Gawande M. Fibrosarcoma of the oral cavity. Indian J Dent Res. 2010; 21: 295–298. [PubMed] [Google Scholar]
19. Yuwanati MB, Tupkari JV. Fibrosarcoma of mandible: a case report. Case Rep Dent. 2011; 2011: 536086. [PMC free article] [PubMed] [Google Scholar]
20. Wong SL. Diagnosis and management of desmoid tumors and fibrosarcoma. J Surg Oncol. 2008; 97: 554–558. [PubMed] [Google Scholar]
21. Bahrami A, Folpe AL. Adult-type fibrosarcoma: A reevaluation of 163 putative cases diagnosed at a single institution over a 48-year period. Am J Surg Pathol. 2010; 34: 1504–1513. [PubMed] [Google Scholar]
22. Ng TL, Gown AM, Barry TS, Cheang MC, Chan AK, Turbin DA, et al. Nuclear beta-catenin in mesenchymal tumors. Mod Pathol. 2005; 18: 68–74. [PubMed] [Google Scholar]
23. Flórez-Moreno GA, Henao-Ruiz M, Santa-Sáenz DM, Castañeda-Peláez DA, Tobón-Arroyave SI. Cytomorphometric and immunohistochemical comparison between central and peripheral giant cell lesions of the jaws. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008; 105: 625–632. [PubMed] [Google Scholar]
24. Deyhimi P, Hashemzadeh Z. Study of the biologic behavior of odontogenic keratocyst and orthokeratinaized odontogenic cyst using TGF-alpha and P53 markers. Pathol Res Pract. 2014; 210: 201–204. [PubMed] [Google Scholar]
25. Gnepp DR. Diagnostic Surgical Pathology of the Head and Neck. 2th ed. Philadelphia : Saunders Elsevier; 2009. p. 460. [Google Scholar]
26. Lin XY, Wang L, Zhang Y, Dai SD, Wang EH. Variable Ki67 proliferative index in 65 cases of nodular fasciitis, compared with fibrosarcoma and fibromatosis. Diagn Pathol. 2013; 8: 50. [PMC free article] [PubMed] [Google Scholar]
27. Clarke LE. Fibrous and fibrohistiocytic neoplasms: an update. Dermatol Clin. 2012; 30: 643–656. [PubMed] [Google Scholar]
28. Amary MF, Pauwels P, Meulemans E, Roemen GM, Islam L, Idowu B, et al. Detection of beta-catenin mutations in paraffin-embedded sporadic desmoid-type fibromatosis by mutation-specific restriction enzyme digestion (MSRED): an ancillary diagnostic tool. Am J Surg Pathol. 2007; 31: 1299–309. [PubMed] [Google Scholar]
29. Bhattacharya B, Dilworth HP, Iacobuzio-Donahue C, Ricci F, Weber K, Furlong MA, et al. Nuclear beta-catenin expression distinguishes deep fibromatosis from other benign and malignant fibroblastic and myofibroblastic lesions. Am J Surg Pathol. 2005; 29: 653–659. [PubMed] [Google Scholar] | ||
|
آمار تعداد مشاهده مقاله: 1,390 تعداد دریافت فایل اصل مقاله: 846 |
||