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Shivashankara, Arnadi, Tonse, Raees, Suresh, Sucharitha, George, Thomas, Vidyasagar, Mamidipudi, Rao, Suresh, Baliga,, Manjeshwar. (1398). Salivary Lactate Dehydrogenase (LDH) as a Marker for Radiation-induced Mucositis in Head and Neck Cancers: A Preliminary Study. سامانه مدیریت نشریات علمی, 10(2), 103-110. doi: 10.30476/mejc.2019.81573.1027
Arnadi Shivashankara; Raees Tonse; Sucharitha Suresh; Thomas George; Mamidipudi Srinivasa Vidyasagar; Suresh Rao; Manjeshwar Shrinath Baliga,. "Salivary Lactate Dehydrogenase (LDH) as a Marker for Radiation-induced Mucositis in Head and Neck Cancers: A Preliminary Study". سامانه مدیریت نشریات علمی, 10, 2, 1398, 103-110. doi: 10.30476/mejc.2019.81573.1027
Shivashankara, Arnadi, Tonse, Raees, Suresh, Sucharitha, George, Thomas, Vidyasagar, Mamidipudi, Rao, Suresh, Baliga,, Manjeshwar. (1398). 'Salivary Lactate Dehydrogenase (LDH) as a Marker for Radiation-induced Mucositis in Head and Neck Cancers: A Preliminary Study', سامانه مدیریت نشریات علمی, 10(2), pp. 103-110. doi: 10.30476/mejc.2019.81573.1027
Shivashankara, Arnadi, Tonse, Raees, Suresh, Sucharitha, George, Thomas, Vidyasagar, Mamidipudi, Rao, Suresh, Baliga,, Manjeshwar. Salivary Lactate Dehydrogenase (LDH) as a Marker for Radiation-induced Mucositis in Head and Neck Cancers: A Preliminary Study. سامانه مدیریت نشریات علمی, 1398; 10(2): 103-110. doi: 10.30476/mejc.2019.81573.1027

Salivary Lactate Dehydrogenase (LDH) as a Marker for Radiation-induced Mucositis in Head and Neck Cancers: A Preliminary Study

Middle East Journal of Cancer
مقاله 4، دوره 10، شماره 2 - شماره پیاپی 38، تیر 2019، صفحه 103-110    اصل مقاله (1.79 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2019.81573.1027
نویسندگان
Arnadi Shivashankara1؛ Raees Tonse2؛ Sucharitha Suresh3؛ Thomas George3؛ Mamidipudi Srinivasa Vidyasagar2؛ Suresh Rao4؛ Manjeshwar Shrinath Baliga,* 4
1Departments of Biochemistry Father Muller Medical College, Mangalore, Karnataka, India
2Radiation Oncology Father Muller Medical College, Mangalore, Karnataka, India
3Community Medicine, MBBS student, Father Muller Medical College, Mangalore, Karnataka, India
4Radiation Oncology, Mangalore Institute of Oncology, Pumpwell, Mangalore, Karnataka, India
چکیده
Background: In this study, we sought to understand the usefulness of salivary lactate
dehydrogenase as a predictive marker for the development of radiation-induced
mucositis.
Methods: This was a prospective study with head and neck cancer patients who
required curative radiotherapy (>60Gy). We collected patients’ saliva before the onset
of radiation and after 2 Gy of radiation to assess lactate dehydrogenase levels. The patients
received the stipulated oral and dental care. Data on incidence and severity of mucositis
was collected using a preform sheet and oral mucositis assessment scale published by
the Radiation Therapy Oncology Group throughout the 7-week treatment period.
Results: Salivary lactate dehydrogenase increased with exposure to radiation
(P<0.0001) and there was an observed association with mucositis severity (P<0.0001;
r = 0.515).
Conclusion: The present results have established, for the first time, that salivary
lactate dehydrogenase could be a useful predictive marker to understand the development
of radiation-induced mucositis in patients with head and neck cancer. The proximity
of the oral cavity for regular observation and saliva collection is an added advantage.
کلیدواژه‌ها
Head and neck cancer؛ Salivary lactate dehydrogenase؛ Mucositis
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