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Salivary Lactate Dehydrogenase (LDH) as a Marker for Radiation-induced Mucositis in Head and Neck Cancers: A Preliminary Study | ||
Middle East Journal of Cancer | ||
مقاله 4، دوره 10، شماره 2 - شماره پیاپی 38، تیر 2019، صفحه 103-110 اصل مقاله (1.79 M) | ||
نوع مقاله: Original Article(s) | ||
شناسه دیجیتال (DOI): 10.30476/mejc.2019.81573.1027 | ||
نویسندگان | ||
Arnadi Shivashankara1؛ Raees Tonse2؛ Sucharitha Suresh3؛ Thomas George3؛ Mamidipudi Srinivasa Vidyasagar2؛ Suresh Rao4؛ Manjeshwar Shrinath Baliga,* 4 | ||
1Departments of Biochemistry Father Muller Medical College, Mangalore, Karnataka, India | ||
2Radiation Oncology Father Muller Medical College, Mangalore, Karnataka, India | ||
3Community Medicine, MBBS student, Father Muller Medical College, Mangalore, Karnataka, India | ||
4Radiation Oncology, Mangalore Institute of Oncology, Pumpwell, Mangalore, Karnataka, India | ||
چکیده | ||
Background: In this study, we sought to understand the usefulness of salivary lactate dehydrogenase as a predictive marker for the development of radiation-induced mucositis. Methods: This was a prospective study with head and neck cancer patients who required curative radiotherapy (>60Gy). We collected patients’ saliva before the onset of radiation and after 2 Gy of radiation to assess lactate dehydrogenase levels. The patients received the stipulated oral and dental care. Data on incidence and severity of mucositis was collected using a preform sheet and oral mucositis assessment scale published by the Radiation Therapy Oncology Group throughout the 7-week treatment period. Results: Salivary lactate dehydrogenase increased with exposure to radiation (P<0.0001) and there was an observed association with mucositis severity (P<0.0001; r = 0.515). Conclusion: The present results have established, for the first time, that salivary lactate dehydrogenase could be a useful predictive marker to understand the development of radiation-induced mucositis in patients with head and neck cancer. The proximity of the oral cavity for regular observation and saliva collection is an added advantage. | ||
کلیدواژهها | ||
Head and neck cancer؛ Salivary lactate dehydrogenase؛ Mucositis | ||
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