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Srivastava, Sh, Painuly, N K, Mishra, S P, Srivastava, K, Singh, N, Singh, S, Bhatt, M L B. (1398). Evaluation of Volumetric Doses of Organs at Risk in Carcinoma Cervix Patients with HDR Intracavitary Brachytherapy and Comparison of CT-based and Conventional Plans. سامانه مدیریت نشریات علمی, 9(6), 603-612. doi: 10.31661/jbpe.v0i0.867
Sh Srivastava; N K Painuly; S P Mishra; K Srivastava; N Singh; S Singh; M L B Bhatt. "Evaluation of Volumetric Doses of Organs at Risk in Carcinoma Cervix Patients with HDR Intracavitary Brachytherapy and Comparison of CT-based and Conventional Plans". سامانه مدیریت نشریات علمی, 9, 6, 1398, 603-612. doi: 10.31661/jbpe.v0i0.867
Srivastava, Sh, Painuly, N K, Mishra, S P, Srivastava, K, Singh, N, Singh, S, Bhatt, M L B. (1398). 'Evaluation of Volumetric Doses of Organs at Risk in Carcinoma Cervix Patients with HDR Intracavitary Brachytherapy and Comparison of CT-based and Conventional Plans', سامانه مدیریت نشریات علمی, 9(6), pp. 603-612. doi: 10.31661/jbpe.v0i0.867
Srivastava, Sh, Painuly, N K, Mishra, S P, Srivastava, K, Singh, N, Singh, S, Bhatt, M L B. Evaluation of Volumetric Doses of Organs at Risk in Carcinoma Cervix Patients with HDR Intracavitary Brachytherapy and Comparison of CT-based and Conventional Plans. سامانه مدیریت نشریات علمی, 1398; 9(6): 603-612. doi: 10.31661/jbpe.v0i0.867

Evaluation of Volumetric Doses of Organs at Risk in Carcinoma Cervix Patients with HDR Intracavitary Brachytherapy and Comparison of CT-based and Conventional Plans

Journal of Biomedical Physics and Engineering
مقاله 3، دوره 9، شماره 6، بهمن و اسفند 2019، صفحه 603-612    اصل مقاله (1001.89 K)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.867
نویسندگان
Sh Srivastava* 1؛ N K Painuly2؛ S P Mishra3؛ K Srivastava4؛ N Singh5؛ S Singh6؛ M L B Bhatt7
1MSc, Assistant Professor, Department of Radiotherapy, King George’s Medical University,Lucknow, Uttar Pradesh, India
2PhD, Professor of Medical Physics, Department of Radiotherapy King George’s Medical University, Lucknow, Uttar Pradesh, India
3PhD, Senior Scientist, Department of Radiation Oncology Dr. Ram Manohar Lohia Institute of Medical Sciences,Lucknow, Uttar Pradesh India
4MD, Professor of Radiation Oncology, Department of Radiotherapy King George’s Medical University, Lucknow, Uttar Pradesh, India
5PhD, Assistant Professor of Medical Physics, Department of Radiotherapy King George’s Medical University, Lucknow, Uttar Pradesh, India
6MD, Associate Professor of Radiation Oncology, Department of Radiotherapy King George’s Medical University, Lucknow, Uttar Pradesh, India
7MD, Vice Chancellor, Professor of Radiation Oncology King George’s Medical University, Lucknow, Uttar Pradesh, India
چکیده
Background: Brachytherapy treatment planning in cervix carcinoma patients using two dimensional (2D) orthogonal images provides only point dose estimates while CT-based planning provides volumetric dose assessment helping in understanding the correlation between morbidity and the dose to organs at risk (OARs) and treatment volume.
Objective: Aim of present study is to compare International Commission on Radiation Units and Measurements Report 38 (ICRU 38) reference point doses to OARs with volumetric doses using 2D images and CT images in patients with cervical cancer.
Material and Methods: In this prospective study, 20 patients with cervical cancer stages (IIB-IIIB) were planned for a brachytherapy dose of 7Gy per fraction for three fractions using 2D image-based treatment plan and CT-based plan. ICRU 38 points for bladder and rectum were identified on both 2D image-based plan and CT-based plan and doses (DICRU) at these points were compared to the minimum dose to 2cc volume (D2cc) of bladder and rectum receiving the highest dose.
Results: D2cc bladder dose was 1.60 (±0.67) times more than DICRUb bladder dose whereas D2cc rectum dose was 1.13±0.40 times DICRUr. Significant difference was found between DICRUb and D2cc dose for bladder (p=.0.016) while no significant difference was seen between DICRUr and D2cc dose for rectum (p=0.964).
Conclusion: The study suggests that ICRU 38 point doses are not the true representation of maximum doses to OARs. CT-based treatment planning is more a reliable tool for OAR dose assessment than the conventional 2D radiograph-based plan.
کلیدواژه‌ها
Brachytherapy؛ Organs at Risk؛ Radiography
مراجع
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