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Shurche, S, Riyahi Alam, N. (1399). Simulation of Capillary Hemodynamics and Comparison with Experimental Results of Microphantom Perfusion Weighted Imaging. سامانه مدیریت نشریات علمی, 10(3), 291-298. doi: 10.31661/jbpe.v0i0.910
S Shurche; N Riyahi Alam. "Simulation of Capillary Hemodynamics and Comparison with Experimental Results of Microphantom Perfusion Weighted Imaging". سامانه مدیریت نشریات علمی, 10, 3, 1399, 291-298. doi: 10.31661/jbpe.v0i0.910
Shurche, S, Riyahi Alam, N. (1399). 'Simulation of Capillary Hemodynamics and Comparison with Experimental Results of Microphantom Perfusion Weighted Imaging', سامانه مدیریت نشریات علمی, 10(3), pp. 291-298. doi: 10.31661/jbpe.v0i0.910
Shurche, S, Riyahi Alam, N. Simulation of Capillary Hemodynamics and Comparison with Experimental Results of Microphantom Perfusion Weighted Imaging. سامانه مدیریت نشریات علمی, 1399; 10(3): 291-298. doi: 10.31661/jbpe.v0i0.910

Simulation of Capillary Hemodynamics and Comparison with Experimental Results of Microphantom Perfusion Weighted Imaging

Journal of Biomedical Physics and Engineering
مقاله 6، دوره 10، شماره 3، شهریور 2020، صفحه 291-298    اصل مقاله (1.37 M)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.910
نویسندگان
S Shurche1؛ N Riyahi Alam* 2، 3، 4
1MSc Student, Physics and Medical Engineering Department, Medical Faculty, Tehran University of Medical Sciences, Tehran, Iran
2PhD, Department of Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran
3PhD, PERFORM Preventive Medicine and Health Care Center, Concordia University, Montreal, Quebec, Canada
4PhD, Medical Pharmaceutical Sciences Research Center (MPRC), The institute of Pharmaceutical Sciences, tehran University of Medical Sciences, Tehran, Iran
چکیده
Background: Perfusion imaging, one of MRI’s techniques, is widely used to test damaged tissues of the body. The parameters used in this technique include cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT). The MRI scanner contains a device called a “phantom”, which controls the accuracy of various imaging models.
Objective: Our goal is to design and produce a microphantom to control the perfusion-imaging model in MRI scanners.
Material and Methods: Firstly, in an analytical study type, we designed the phantom based on Murray’s minimum work rule using AutoCAD software. Next, the phantom was fabricated using lithography and then imaged using a Siemens Magnetom 3T Prisma MRI scanner at the National Brain Laboratory. Finally, the velocity and pressure in the capillary network was simulated using COMSOL software.
Results: CBF, CBV, and MTT curves for the capillary network were obtained at different times. In addition, the simulations showed that the velocity and pressure in the capillary network were between 0.0001 and 0.0005 m/s and between 5 and 25 mm/Hg, respectively.
Conclusion: The fabricated microphantom was used to simulate the movement of blood within tissues of the body. Different parameters of perfusion imaging were measured inside the phantom, and they in the phantom were similar to in the body.
کلیدواژه‌ها
Perfusion Imaging؛ Phantoms, Imaging؛ Cerebral Blood Volume؛ Capillary Hemodynamics؛ Contrast Media
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مراجع
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