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Shurche, S, Riyahi Alam, N. (1399). Simulation of Capillary Hemodynamics and Comparison with Experimental Results of Microphantom Perfusion Weighted Imaging. سامانه مدیریت نشریات علمی, 10(3), 291-298. doi: 10.31661/jbpe.v0i0.910
S Shurche; N Riyahi Alam. "Simulation of Capillary Hemodynamics and Comparison with Experimental Results of Microphantom Perfusion Weighted Imaging". سامانه مدیریت نشریات علمی, 10, 3, 1399, 291-298. doi: 10.31661/jbpe.v0i0.910
Shurche, S, Riyahi Alam, N. (1399). 'Simulation of Capillary Hemodynamics and Comparison with Experimental Results of Microphantom Perfusion Weighted Imaging', سامانه مدیریت نشریات علمی, 10(3), pp. 291-298. doi: 10.31661/jbpe.v0i0.910
Shurche, S, Riyahi Alam, N. Simulation of Capillary Hemodynamics and Comparison with Experimental Results of Microphantom Perfusion Weighted Imaging. سامانه مدیریت نشریات علمی, 1399; 10(3): 291-298. doi: 10.31661/jbpe.v0i0.910

Simulation of Capillary Hemodynamics and Comparison with Experimental Results of Microphantom Perfusion Weighted Imaging

Journal of Biomedical Physics and Engineering
مقاله 6، دوره 10، شماره 3، مرداد و شهریور 2020، صفحه 291-298    اصل مقاله (1.37 M)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.910
نویسندگان
S Shurche1؛ N Riyahi Alam* 2، 3، 4
1MSc Student, Physics and Medical Engineering Department, Medical Faculty, Tehran University of Medical Sciences, Tehran, Iran
2PhD, Department of Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran
3PhD, PERFORM Preventive Medicine and Health Care Center, Concordia University, Montreal, Quebec, Canada
4PhD, Medical Pharmaceutical Sciences Research Center (MPRC), The institute of Pharmaceutical Sciences, tehran University of Medical Sciences, Tehran, Iran
چکیده
Background: Perfusion imaging, one of MRI’s techniques, is widely used to test damaged tissues of the body. The parameters used in this technique include cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT). The MRI scanner contains a device called a “phantom”, which controls the accuracy of various imaging models.
Objective: Our goal is to design and produce a microphantom to control the perfusion-imaging model in MRI scanners.
Material and Methods: Firstly, in an analytical study type, we designed the phantom based on Murray’s minimum work rule using AutoCAD software. Next, the phantom was fabricated using lithography and then imaged using a Siemens Magnetom 3T Prisma MRI scanner at the National Brain Laboratory. Finally, the velocity and pressure in the capillary network was simulated using COMSOL software.
Results: CBF, CBV, and MTT curves for the capillary network were obtained at different times. In addition, the simulations showed that the velocity and pressure in the capillary network were between 0.0001 and 0.0005 m/s and between 5 and 25 mm/Hg, respectively.
Conclusion: The fabricated microphantom was used to simulate the movement of blood within tissues of the body. Different parameters of perfusion imaging were measured inside the phantom, and they in the phantom were similar to in the body.
کلیدواژه‌ها
Perfusion Imaging؛ Phantoms, Imaging؛ Cerebral Blood Volume؛ Capillary Hemodynamics؛ Contrast Media
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مراجع
  1. Ostergaard L, Aamand R, Gutierrez-Jimenez E, Ho YC, Blicher JU, Madsen SM, et al. The capillary dysfunction hypothesis of Alzheimer’s disease. Neurobiol Aging. 2013;34:1018-31. doi: 10.1016/j.neurobiolaging.2012.09.011. PubMed PMID: 23084084.
  2. Wintermark M, Sesay M, Barbier E, Borbely K, Dillon WP, Eastwood JD, et al. Comparative overview of brain perfusion imaging techniques. Stroke. 2005;36:e83-99. doi: 10.1161/01.STR.0000177884.72657.8b. PubMed PMID: 16100027.
  3. Kato H, Kuroda M, Yoshimura K, Yoshida A, Hanamoto K, Kawasaki S, et al. Composition of MRI phantom equivalent to human tissues. Med Phys. 2005;32:3199-208. doi: 10.1118/1.2047807. PubMed PMID: 16279073.
  4. Kety SS, Schmidt CF. The determination of cerebral blood flow in man by the use of nitrous oxide in low concentrations. American Journal of Physiology-Legacy Content. 1945;143:53-66.
  5. Meier P, Zierler KL. On the theory of the indicator-dilution method for measurement of blood flow and volume. J Appl Physiol. 1954;6:731-44. doi: 10.1152/jappl.1954.6.12.731. PubMed PMID: 13174454.
  6. Copen WA, Schaefer PW, Wu O. MR perfusion imaging in acute ischemic stroke. Neuroimaging Clin N Am. 2011;21:259-x. doi: 10.1016/j.nic.2011.02.007. PubMed PMID: 21640299. PubMed PMCID: PMC3135980.
  7. Murray CD. The Physiological Principle of Minimum Work: I. The Vascular System and the Cost of Blood Volume. Proc Natl Acad Sci U S A. 1926;12:207-14. PubMed PMID: 16576980. PubMed PMCID: PMC1084489.
  8. Rossitti S, Lofgren J. Vascular dimensions of the cerebral arteries follow the principle of minimum work. Stroke. 1993;24:371-7. PubMed PMID: 8446972.
  9. Emerson DR, Cieslicki K, Gu X, Barber RW. Biomimetic design of microfluidic manifolds based on a generalised Murray’s law. Lab Chip. 2006;6:447-54. doi: 10.1039/b516975e. PubMed PMID: 16511629.
  10. Pawlik G, Rackl A, Bing RJ. Quantitative capillary topography and blood flow in the cerebral cortex of cats: an in vivo microscopic study. Brain Res. 1981;208:35-58.
  11. Cassot F, Lauwers F, Fouard C, Prohaska S, Lauwers-Cances V. A novel three-dimensional computer-assisted method for a quantitative study of microvascular networks of the human cerebral cortex. Microcirculation. 2006;13:1-18. doi: 10.1080/10739680500383407. PubMed PMID: 16393942.
  12. Ivanov KP, Kalinina MK, Levkovich Yu I. Blood flow velocity in capillaries of brain and muscles and its physiological significance. Microvasc Res. 1981;22:143-55. PubMed PMID: 7321902.
  13. Shore AC. Capillaroscopy and the measurement of capillary pressure. Br J Clin Pharmacol. 2000;50:501-13. PubMed PMID: 11136289. PubMed PMCID: PMC2015012.
  14. Calamante F, Morup M, Hansen LK. Defining a local arterial input function for perfusion MRI using independent component analysis. Magn Reson Med. 2004;52:789-97. doi: 10.1002/mrm.20227. PubMed PMID: 15389944.
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