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Shafiekhani, Sajad, Poursheykhani, Arash, Rahbar, Sara, Jafari, Amir Homayoun. (1400). Simulating ATO Mechanism and EGFR Signaling with Fuzzy Logic and Petri Net. سامانه مدیریت نشریات علمی, 11(3), 325-336. doi: 10.31661/jbpe.v0i0.796
Sajad Shafiekhani; Arash Poursheykhani; Sara Rahbar; Amir Homayoun Jafari. "Simulating ATO Mechanism and EGFR Signaling with Fuzzy Logic and Petri Net". سامانه مدیریت نشریات علمی, 11, 3, 1400, 325-336. doi: 10.31661/jbpe.v0i0.796
Shafiekhani, Sajad, Poursheykhani, Arash, Rahbar, Sara, Jafari, Amir Homayoun. (1400). 'Simulating ATO Mechanism and EGFR Signaling with Fuzzy Logic and Petri Net', سامانه مدیریت نشریات علمی, 11(3), pp. 325-336. doi: 10.31661/jbpe.v0i0.796
Shafiekhani, Sajad, Poursheykhani, Arash, Rahbar, Sara, Jafari, Amir Homayoun. Simulating ATO Mechanism and EGFR Signaling with Fuzzy Logic and Petri Net. سامانه مدیریت نشریات علمی, 1400; 11(3): 325-336. doi: 10.31661/jbpe.v0i0.796

Simulating ATO Mechanism and EGFR Signaling with Fuzzy Logic and Petri Net

Journal of Biomedical Physics and Engineering
مقاله 8، دوره 11، شماره 3، شهریور 2021، صفحه 325-336    اصل مقاله (1.24 M)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.796
نویسندگان
Sajad Shafiekhani1، 2؛ Arash Poursheykhani3؛ Sara Rahbar1، 2؛ Amir Homayoun Jafari* 4، 5
1PhD Candidate, Department of Biophysics & Biomedical Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2PhD Candidate, Research center for Science and Technology in Medicine (RCSTIM), Tehran University of Medical Sciences, Tehran, Iran
3PhD Candidate, Department of Medical Genetics, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran
4PhD, Department of Biophysics & Biomedical Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
5PhD, Research center for Science and Technology in Medicine (RCSTIM), Tehran University of Medical Sciences, Tehran, Iran
چکیده
Background: Interactions of many key proteins or genes in signalling pathway have been studied qualitatively in the literature, but only little quantitative information is available.
Objective: Although much has been done to clarify the biochemistry of transcriptional dynamics in signalling pathway, it remains difficult to find out and predict quantitative responses. The aim of this study is to construct a computational model of epidermal growth factor receptor (EGFR) signalling pathway as one of hallmarks of cancer so as to predict quantitative responses.
Material and Methods: In this analytical study, we presented a computational model to investigate EGFR signalling pathway. Interaction of Arsenic trioxide (ATO) with EGFR signalling pathway factors has been elicited by systematic search in data bases, as ATO is one of the mysterious chemotherapy agents that control EGFR expression in cancer. ATO has dichotomous manner in vivo, dependent on its concentration. According to fuzzy rules based upon qualitative knowledge and Petri Net, we can construct a quantitative model to describe ATO mechanism in EGFR signalling pathway.
Results: By Fuzzy Logic models that have the potential to trade with the loss of quantitative information on how different species interact, along with Petri net quantitatively describe the dynamics of EGFR signalling pathway. By this model the dynamic of different factors in EGFR signalling pathway is achieved.
Conclusion: The use of Fuzzy Logic and PNs in biological network modelling causes a deeper understanding and comprehensive analysis of the biological networks.
کلیدواژه‌ها
Arsenic Trioxide؛ EGFR؛ Fuzzy Logic Model؛ Petri Net؛ Signalling pathway؛ Logic؛ Algorithms؛ Theoretical
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