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Haghani, M, Pouladvand, V, Mortazavi, S M J, Razavinasab, M, Bayat, M, Shabani, M. (1399). Exposure to Electromagnetic Field during Gestation Adversely Affects the Electrophysiological Properties of Purkinje Cells in Rat Offspring. سامانه مدیریت نشریات علمی, 10(4), 433-440. doi: 10.31661/jbpe.v0i0.560
M Haghani; V Pouladvand; S M J Mortazavi; M Razavinasab; M Bayat; M Shabani. "Exposure to Electromagnetic Field during Gestation Adversely Affects the Electrophysiological Properties of Purkinje Cells in Rat Offspring". سامانه مدیریت نشریات علمی, 10, 4, 1399, 433-440. doi: 10.31661/jbpe.v0i0.560
Haghani, M, Pouladvand, V, Mortazavi, S M J, Razavinasab, M, Bayat, M, Shabani, M. (1399). 'Exposure to Electromagnetic Field during Gestation Adversely Affects the Electrophysiological Properties of Purkinje Cells in Rat Offspring', سامانه مدیریت نشریات علمی, 10(4), pp. 433-440. doi: 10.31661/jbpe.v0i0.560
Haghani, M, Pouladvand, V, Mortazavi, S M J, Razavinasab, M, Bayat, M, Shabani, M. Exposure to Electromagnetic Field during Gestation Adversely Affects the Electrophysiological Properties of Purkinje Cells in Rat Offspring. سامانه مدیریت نشریات علمی, 1399; 10(4): 433-440. doi: 10.31661/jbpe.v0i0.560

Exposure to Electromagnetic Field during Gestation Adversely Affects the Electrophysiological Properties of Purkinje Cells in Rat Offspring

Journal of Biomedical Physics and Engineering
مقاله 5، دوره 10، شماره 4، آبان 2020، صفحه 433-440    اصل مقاله (785.5 K)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.560
نویسندگان
M Haghani1؛ V Pouladvand2؛ S M J Mortazavi3، 4؛ M Razavinasab5؛ M Bayat6؛ M Shabani* 5، 7
1PhD, Histomorphometry and Stereology Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran
2MSc, Department of Biochemical, Jiroft University of Medical Sciences, Jiroft, Kerman, Iran
3PhD, Ionizing and Non-Ionizing Radiation Protection Research Center, Paramedical School, Shiraz University of Medical Sciences, Shiraz, Iran
4PhD, Department of Medical Physics, Shiraz University of Medical Sciences, Shiraz, Iran
5PhD, Kerman Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran
6PhD, Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
7PhD, Jiroft University of Medical Sciences, Jiroft, Kerman, Iran
چکیده
Background: Prenatal adverse effects of radiofrequency electromagnetic fields (RF-EMF) exposure on nervous system are an issue of major concern.
Objective: Thus, in this study we evaluated the membrane current flow properties of Purkinje neurons after maternal exposure to 900 MHz pulsed RF-EMF.
Material and Methods: In this experimental study, during all days of pregnancy, rats in the EMF-exposed group were exposed to 900 MHz pulsed-EMF radiation for 6 h per day. The effects of RF-EMF exposure on the electrophysiological properties of the Purkinje cerebellum neurons from male pups were evaluated by whole-cell patch clamp recordings in current and voltage clamp modes. In voltage-clamp experiments, the holding potential was -60 mV, and a depolarizing voltage step (1000 ms duration) was applied from -60 to +50 mV in 10 mV increments at 2s intervals.
Results: The exposure group demonstrated reduced spontaneous firing associated with upward and rightward shift in I/V curve compared to the control rats. Moreover, the peak amplitude of the current for the exposure pups also revealed a significant decrement. The reversal potential was +40 mV and +20 mV for the control and RF-EMF groups, respectively and showed significant differences between the two groups.
Conclusion: The decrease in ion’s conductance could be attributed to the observed decrease in the voltage onset of the inward current, peak amplitude and voltage shift.
کلیدواژه‌ها
Electrophysiological Properties؛ Cell Phone؛ Purkinje Cells؛ Prenatal Injuries
سایر فایل های مرتبط با مقاله
مراجع
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