LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,230
تعداد مقالات11,205
تعداد مشاهده مقاله78,000,890
تعداد دریافت فایل اصل مقاله103,512,067
Haghani, M, Pouladvand, V, Mortazavi, S M J, Razavinasab, M, Bayat, M, Shabani, M. (1399). Exposure to Electromagnetic Field during Gestation Adversely Affects the Electrophysiological Properties of Purkinje Cells in Rat Offspring. سامانه مدیریت نشریات علمی, 10(4), 433-440. doi: 10.31661/jbpe.v0i0.560
M Haghani; V Pouladvand; S M J Mortazavi; M Razavinasab; M Bayat; M Shabani. "Exposure to Electromagnetic Field during Gestation Adversely Affects the Electrophysiological Properties of Purkinje Cells in Rat Offspring". سامانه مدیریت نشریات علمی, 10, 4, 1399, 433-440. doi: 10.31661/jbpe.v0i0.560
Haghani, M, Pouladvand, V, Mortazavi, S M J, Razavinasab, M, Bayat, M, Shabani, M. (1399). 'Exposure to Electromagnetic Field during Gestation Adversely Affects the Electrophysiological Properties of Purkinje Cells in Rat Offspring', سامانه مدیریت نشریات علمی, 10(4), pp. 433-440. doi: 10.31661/jbpe.v0i0.560
Haghani, M, Pouladvand, V, Mortazavi, S M J, Razavinasab, M, Bayat, M, Shabani, M. Exposure to Electromagnetic Field during Gestation Adversely Affects the Electrophysiological Properties of Purkinje Cells in Rat Offspring. سامانه مدیریت نشریات علمی, 1399; 10(4): 433-440. doi: 10.31661/jbpe.v0i0.560

Exposure to Electromagnetic Field during Gestation Adversely Affects the Electrophysiological Properties of Purkinje Cells in Rat Offspring

Journal of Biomedical Physics and Engineering
مقاله 5، دوره 10، شماره 4، آبان 2020، صفحه 433-440    اصل مقاله (785.5 K)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.560
نویسندگان
M Haghani1؛ V Pouladvand2؛ S M J Mortazavi3، 4؛ M Razavinasab5؛ M Bayat6؛ M Shabani* 5، 7
1PhD, Histomorphometry and Stereology Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran
2MSc, Department of Biochemical, Jiroft University of Medical Sciences, Jiroft, Kerman, Iran
3PhD, Ionizing and Non-Ionizing Radiation Protection Research Center, Paramedical School, Shiraz University of Medical Sciences, Shiraz, Iran
4PhD, Department of Medical Physics, Shiraz University of Medical Sciences, Shiraz, Iran
5PhD, Kerman Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran
6PhD, Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
7PhD, Jiroft University of Medical Sciences, Jiroft, Kerman, Iran
چکیده
Background: Prenatal adverse effects of radiofrequency electromagnetic fields (RF-EMF) exposure on nervous system are an issue of major concern.
Objective: Thus, in this study we evaluated the membrane current flow properties of Purkinje neurons after maternal exposure to 900 MHz pulsed RF-EMF.
Material and Methods: In this experimental study, during all days of pregnancy, rats in the EMF-exposed group were exposed to 900 MHz pulsed-EMF radiation for 6 h per day. The effects of RF-EMF exposure on the electrophysiological properties of the Purkinje cerebellum neurons from male pups were evaluated by whole-cell patch clamp recordings in current and voltage clamp modes. In voltage-clamp experiments, the holding potential was -60 mV, and a depolarizing voltage step (1000 ms duration) was applied from -60 to +50 mV in 10 mV increments at 2s intervals.
Results: The exposure group demonstrated reduced spontaneous firing associated with upward and rightward shift in I/V curve compared to the control rats. Moreover, the peak amplitude of the current for the exposure pups also revealed a significant decrement. The reversal potential was +40 mV and +20 mV for the control and RF-EMF groups, respectively and showed significant differences between the two groups.
Conclusion: The decrease in ion’s conductance could be attributed to the observed decrease in the voltage onset of the inward current, peak amplitude and voltage shift.
کلیدواژه‌ها
Electrophysiological Properties؛ Cell Phone؛ Purkinje Cells؛ Prenatal Injuries
سایر فایل های مرتبط با مقاله
مراجع
  1. Rafati A, Rahimi S, Talebi A, Soleimani A, Haghani M, Mortazavi SM. Exposure to Radiofrequency Radiation Emitted from Common Mobile Phone Jammers Alters the Pattern of Muscle Contractions: an Animal Model Study. J Biomed Phys Eng. 2015;5:133-42. PubMed PMID: 26396969. PubMed PMCID: 4576874.
  2. Mortazavi SMJ, Rahimi S, Talebi A, Soleimani A, Rafati A. Survey of the Effects of Exposure to 900 MHz Radiofrequency Radiation Emitted by a GSM Mobile Phone on the Pattern of Muscle Contractions in an Animal Model. J Biomed Phys Eng. 2015;5:121-32. PubMed PMID: 26396968. PubMed PMCID: 4576873.
  3. Cheng X, Dib-Hajj SD, Tyrrell L, Waxman SG. Mutation I136V alters electrophysiological properties of the Na(v)1.7 channel in a family with onset of erythromelalgia in the second decade. Mol Pain. 2008;4:1. doi: 10.1186/1744-8069-4-1. PubMed PMID: 18171466. PubMed PMCID: 2262064.
  4. Preece AW, Goodfellow S, Wright MG, Butler SR, Dunn EJ, Johnson Y, et al. Effect of 902 MHz mobile phone transmission on cognitive function in children. Bioelectromagnetics. 2005;Suppl 7:S138-43. doi: 10.1002/bem.20128. PubMed PMID: 15931678.
  5. Haghani M, Shabani M, Moazzami K. Maternal mobile phone exposure adversely affects the electrophysiological properties of Purkinje neurons in rat offspring. Neuroscience. 2013;250:588-98. doi: 10.1016/j.neuroscience.2013.07.049. PubMed PMID: 23906636.
  6. Razavinasab M, Moazzami K, Shabani M. Maternal mobile phone exposure alters intrinsic electrophysiological properties of CA1 pyramidal neurons in rat offspring. Toxicol Ind Health. 2016;32:968-79. doi: 10.1177/0748233714525497. PubMed PMID: 24604340.
  7. Koivisto M, Krause CM, Revonsuo A, Laine M, Hamalainen H. The effects of electromagnetic field emitted by GSM phones on working memory. Neuroreport. 2000;11:1641-3. doi: 10.1097/00001756-200006050-00009. PubMed PMID: 10852216.
  8. Mortazavi SMJ, Rouintan MS, Taeb S, Dehghan N, Ghaffarpanah AA, Sadeghi Z, et al. Human short-term exposure to electromagnetic fields emitted by mobile phones decreases computer-assisted visual reaction time. Acta Neurol Belg. 2012;112:171-5. doi: 10.1007/s13760-012-0044-y. PubMed PMID: 22426673.
  9. Mortazavi SMJ, Taeb S, Dehghan N. Alterations of visual reaction time and short term memory in military radar personnel. Iran J Public Health. 2013;42:428-35. PubMed PMID: 23785684. PubMed PMCID: 3684731.
  10. Odaci E, Bas O, Kaplan S. Effects of prenatal exposure to a 900 MHz electromagnetic field on the dentate gyrus of rats: a stereological and histopathological study. Brain Res. 2008;1238:224-9. doi: 10.1016/j.brainres.2008.08.013. PubMed PMID: 18761003.
  11. Bas O, Odaci E, Mollaoglu H, Ucok K, Kaplan S. Chronic prenatal exposure to the 900 megahertz electromagnetic field induces pyramidal cell loss in the hippocampus of newborn rats. Toxicol Ind Health. 2009;25:377-84. doi: 10.1177/0748233709106442. PubMed PMID: 19671630.
  12. Odaci E, Hanci H, Ikinci A, Sonmez OF, Aslan A, Sahin A, et al. Maternal exposure to a continuous 900-MHz electromagnetic field provokes neuronal loss and pathological changes in cerebellum of 32-day-old female rat offspring. J Chem Neuroanat. 2016;75:105-10. PubMed PMID: 26391347.
  13. Ogawa K, Nabae K, Wang J, Wake K, Watanabe S, Kawabe M, et al. Effects of gestational exposure to 1.95-GHz W-CDMA signals for IMT-2000 cellular phones: Lack of embryotoxicity and teratogenicity in rats. Bioelectromagnetics. 2009;30:205-12. doi: 10.1002/bem.20456. PubMed PMID: 19194858.
  14. Takahashi S, Imai N, Nabae K, Wake K, Kawai H, Wang J, et al. Lack of adverse effects of whole-body exposure to a mobile telecommunication electromagnetic field on the rat fetus. Radiat Res. 2010;173:362-72. doi: 10.1667/RR1615.1. PubMed PMID: 20199221.
  15. Klose M, Grote K, Spathmann O, Streckert J, Clemens M, Hansen VW, et al. Effects of early-onset radiofrequency electromagnetic field exposure (GSM 900 MHz) on behavior and memory in rats. Radiat Res. 2014;182:435-47. doi: 10.1667/RR13695.1. PubMed PMID: 25251701.
  16. Sonmez OF, Odaci E, Bas O, Kaplan S. Purkinje cell number decreases in the adult female rat cerebellum following exposure to 900 MHz electromagnetic field. Brain Res. 2010;1356:95-101. doi: 10.1016/j.brainres.2010.07.103. PubMed PMID: 20691167.
  17. Aghaei I, Hajali V, Dehpour A, Haghani M, Sheibani V, Shabani M. Alterations in the intrinsic electrophysiological properties of Purkinje neurons in a rat model of hepatic encephalopathy: Relative preventing effect of PPARgamma agonist. Brain Res Bull. 2016;121:16-25. doi: 10.1016/j.brainresbull.2015.12.002. PubMed PMID: 26704786.
  18. Haghani M, Shabani M, Tondar M. The therapeutic potential of berberine against the altered intrinsic properties of the CA1 neurons induced by Abeta neurotoxicity. Eur J Pharmacol. 2015;758:82-8. doi: 10.1016/j.ejphar.2015.03.016. PubMed PMID: 25861937.
  19. Haghani M, Shabani M, Javan M, Motamedi F, Janahmadi M. CB1 cannabinoid receptor activation rescues amyloid beta-induced alterations in behaviour and intrinsic electrophysiological properties of rat hippocampal CA1 pyramidal neurones. Cell Physiol Biochem. 2012;29:391-406. doi: 10.1159/000338494. PubMed PMID: 22508047.
  20. DeCaen PG, Yarov-Yarovoy V, Scheuer T, Catterall WA. Gating charge interactions with the S1 segment during activation of a Na+ channel voltage sensor. Proc Natl Acad Sci U S A. 2011;108:18825-30. doi: 10.1073/pnas.1116449108. PubMed PMID: 22042870. PubMed PMCID: 3219111.
  21. Jung HY, Mickus T, Spruston N. Prolonged sodium channel inactivation contributes to dendritic action potential attenuation in hippocampal pyramidal neurons. J Neurosci. 1997;17:6639-46. PubMed PMID: 9254676.
آمار
تعداد مشاهده مقاله: 2,318
تعداد دریافت فایل اصل مقاله: 1,679


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب