![سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی شیراز](./data/logo.png)
تعداد نشریات | 20 |
تعداد شمارهها | 1,118 |
تعداد مقالات | 10,259 |
تعداد مشاهده مقاله | 42,327,581 |
تعداد دریافت فایل اصل مقاله | 9,251,589 |
Exposure to Electromagnetic Field during Gestation Adversely Affects the Electrophysiological Properties of Purkinje Cells in Rat Offspring | ||
Journal of Biomedical Physics and Engineering | ||
مقاله 5، دوره 10، شماره 4، مهر و آبان 2020، صفحه 433-440 اصل مقاله (785.5 K) | ||
نوع مقاله: Original Research | ||
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.560 | ||
نویسندگان | ||
M Haghani1؛ V Pouladvand2؛ S M J Mortazavi3، 4؛ M Razavinasab5؛ M Bayat6؛ M Shabani* 5، 7 | ||
1PhD, Histomorphometry and Stereology Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran | ||
2MSc, Department of Biochemical, Jiroft University of Medical Sciences, Jiroft, Kerman, Iran | ||
3PhD, Ionizing and Non-Ionizing Radiation Protection Research Center, Paramedical School, Shiraz University of Medical Sciences, Shiraz, Iran | ||
4PhD, Department of Medical Physics, Shiraz University of Medical Sciences, Shiraz, Iran | ||
5PhD, Kerman Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran | ||
6PhD, Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran | ||
7PhD, Jiroft University of Medical Sciences, Jiroft, Kerman, Iran | ||
چکیده | ||
Background: Prenatal adverse effects of radiofrequency electromagnetic fields (RF-EMF) exposure on nervous system are an issue of major concern. Objective: Thus, in this study we evaluated the membrane current flow properties of Purkinje neurons after maternal exposure to 900 MHz pulsed RF-EMF. Material and Methods: In this experimental study, during all days of pregnancy, rats in the EMF-exposed group were exposed to 900 MHz pulsed-EMF radiation for 6 h per day. The effects of RF-EMF exposure on the electrophysiological properties of the Purkinje cerebellum neurons from male pups were evaluated by whole-cell patch clamp recordings in current and voltage clamp modes. In voltage-clamp experiments, the holding potential was -60 mV, and a depolarizing voltage step (1000 ms duration) was applied from -60 to +50 mV in 10 mV increments at 2s intervals. Results: The exposure group demonstrated reduced spontaneous firing associated with upward and rightward shift in I/V curve compared to the control rats. Moreover, the peak amplitude of the current for the exposure pups also revealed a significant decrement. The reversal potential was +40 mV and +20 mV for the control and RF-EMF groups, respectively and showed significant differences between the two groups. Conclusion: The decrease in ion’s conductance could be attributed to the observed decrease in the voltage onset of the inward current, peak amplitude and voltage shift. | ||
کلیدواژهها | ||
Electrophysiological Properties؛ Cell Phone؛ Purkinje Cells؛ Prenatal Injuries | ||
سایر فایل های مرتبط با مقاله
|
||
مراجع | ||
| ||
آمار تعداد مشاهده مقاله: 1,721 تعداد دریافت فایل اصل مقاله: 523 |