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Sadri, Donia, Shahsavari, Fatemeh, Hezarkhani, Maliheh, Shafizadeh, Maryam. (1397). Expression of CD34 and CD31 in Central and Peripheral Giant Cell Granulomas. سامانه مدیریت نشریات علمی, 20(1), 10-15. doi: 10.30476/dentjods.2019.44557
Donia Sadri; Fatemeh Shahsavari; Maliheh Hezarkhani; Maryam Shafizadeh. "Expression of CD34 and CD31 in Central and Peripheral Giant Cell Granulomas". سامانه مدیریت نشریات علمی, 20, 1, 1397, 10-15. doi: 10.30476/dentjods.2019.44557
Sadri, Donia, Shahsavari, Fatemeh, Hezarkhani, Maliheh, Shafizadeh, Maryam. (1397). 'Expression of CD34 and CD31 in Central and Peripheral Giant Cell Granulomas', سامانه مدیریت نشریات علمی, 20(1), pp. 10-15. doi: 10.30476/dentjods.2019.44557
Sadri, Donia, Shahsavari, Fatemeh, Hezarkhani, Maliheh, Shafizadeh, Maryam. Expression of CD34 and CD31 in Central and Peripheral Giant Cell Granulomas. سامانه مدیریت نشریات علمی, 1397; 20(1): 10-15. doi: 10.30476/dentjods.2019.44557

Expression of CD34 and CD31 in Central and Peripheral Giant Cell Granulomas

Journal of Dentistry
مقاله 2، دوره 20، شماره 1، خرداد 2019، صفحه 10-15    اصل مقاله (324.88 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/dentjods.2019.44557
نویسندگان
Donia Sadri* ؛ Fatemeh Shahsavari؛ Maliheh Hezarkhani؛ Maryam Shafizadeh
Dept. of Oral and Maxillofacial Pathology, Dental Branch of Tehran, Islamic Azad University, Tehran, Iran.
چکیده
Statement of the Problem: Considering the clinical differences between central giant cell granulomas (CGCGs) and peripheral giant cell granulomas (CGCGs) despite their same microscopic feature and possible role of angiogenesis in this issue, Purpose: The aim of the present study was to compare microvessel density (MVD) between CGCGs and PGCGs of the oral cavity using CD31 and CD34.Materials and Method: Immunohistochemical staining was performed on 18 PGCGs and 19 CGCGs using a monoclonal antibody against CD34 and CD31. MVD was assessed and compared between the lesions using T-test for statistical analysis. p < 0.05 was considered significant.Results: The expression levels of both CD34 and CD31 were significantly higher in CGCGs compared to PGCGs (p < 0.002 and p < 0.001, respectively). Significant differences in MVD assessed by both markers were observed between males and females in PGCGs (p < 0.05), but not CGCGs (p < 0.2).Conclusion: The combined evaluation of old- and newly-formed vessels by pan-endothelial cell markers showed differences between CGCGs and PGCGs, supporting the possible vascular-proliferative nature of the former. Whether this difference has a part in their diverse biologic behaviors and the role which pre-existent vessels play in comparison to neo-formed vasculature, requires further investigation.
کلیدواژه‌ها
Angiogenesis؛ Pathologic؛ Giant cell Granuloma؛ CD34؛ CD31؛ Jaw
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