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Moradi Monfared, Mohammad, Alizadeh Zarei, Marziyeh, Rafiei Dehbidi, Gholamreza, Behzad Behbahani, Abbas, Arabsolghar, Rita, Takhshid, Mohammad Ali. (1397). NDRG2 Regulates the Expression of Genes Involved in Epithelial Mesenchymal Transition of Prostate Cancer Cells. سامانه مدیریت نشریات علمی, 44(2), 118-126. doi: 10.30476/ijms.2019.44512
Mohammad Moradi Monfared; Marziyeh Alizadeh Zarei; Gholamreza Rafiei Dehbidi; Abbas Behzad Behbahani; Rita Arabsolghar; Mohammad Ali Takhshid. "NDRG2 Regulates the Expression of Genes Involved in Epithelial Mesenchymal Transition of Prostate Cancer Cells". سامانه مدیریت نشریات علمی, 44, 2, 1397, 118-126. doi: 10.30476/ijms.2019.44512
Moradi Monfared, Mohammad, Alizadeh Zarei, Marziyeh, Rafiei Dehbidi, Gholamreza, Behzad Behbahani, Abbas, Arabsolghar, Rita, Takhshid, Mohammad Ali. (1397). 'NDRG2 Regulates the Expression of Genes Involved in Epithelial Mesenchymal Transition of Prostate Cancer Cells', سامانه مدیریت نشریات علمی, 44(2), pp. 118-126. doi: 10.30476/ijms.2019.44512
Moradi Monfared, Mohammad, Alizadeh Zarei, Marziyeh, Rafiei Dehbidi, Gholamreza, Behzad Behbahani, Abbas, Arabsolghar, Rita, Takhshid, Mohammad Ali. NDRG2 Regulates the Expression of Genes Involved in Epithelial Mesenchymal Transition of Prostate Cancer Cells. سامانه مدیریت نشریات علمی, 1397; 44(2): 118-126. doi: 10.30476/ijms.2019.44512

NDRG2 Regulates the Expression of Genes Involved in Epithelial Mesenchymal Transition of Prostate Cancer Cells

Iranian Journal of Medical Sciences
مقاله 4، دوره 44، شماره 2، خرداد 2019، صفحه 118-126    اصل مقاله (1000.63 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2019.44512
نویسندگان
Mohammad Moradi Monfared؛ Marziyeh Alizadeh Zarei؛ Gholamreza Rafiei Dehbidi؛ Abbas Behzad Behbahani؛ Rita Arabsolghar؛ Mohammad Ali Takhshid*
Diagnostic Laboratory Sciences and Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Metastasis is the main cause of prostate cancer (PCa) death. The inhibitory effect of N-myc downstream-regulated gene 2 (NDRG2) on the invasiveness properties of PCa cells has been demonstrated previously. However, its underlying mechanisms have not yet been investigated. The present study aimed to investigate the effects of NDRG2 overexpression on the expression of genes involved in epithelial-mesenchymal transition (EMT) including E-cadherin (E-CAD), α- and β-catenins, Slug and Snail, transforming growth factor (TGF)-α and -β, and vascular endothelial growth factor (VEGF). Methods: In the present in vitro study, LNCaP cells were divided into three groups, namely NDRG2 group (transfected with PSES-pAdenoVator-PSA-NDRG2-IRES-GFP plasmid), mock group (transfected with mock plasmid), and control group (without transfection). The effect of NDRG2 overexpression on the migration and invasion of LNCaP cells were investigated using the transwell assay. Real-time PCR was used for the evaluation of gene expression. For the statistical analyses, one-way ANOVA, student t test or Mann-Whitney U test were applied using the SPSS software (version 15.0). P values
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