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Nobakhti-Afshar, Ahmadreza, Najafpour, Alireza, Mohammadi, Rahim, Zarei, Leila. (1395). Assessment of Neuroprotective Effects of Local Administration of 17- Beta- Estradiol on Peripheral Nerve Regeneration in Ovariectomized Female Rats. سامانه مدیریت نشریات علمی, 4(Issue 3), 141-149.
Ahmadreza Nobakhti-Afshar; Alireza Najafpour; Rahim Mohammadi; Leila Zarei. "Assessment of Neuroprotective Effects of Local Administration of 17- Beta- Estradiol on Peripheral Nerve Regeneration in Ovariectomized Female Rats". سامانه مدیریت نشریات علمی, 4, Issue 3, 1395, 141-149.
Nobakhti-Afshar, Ahmadreza, Najafpour, Alireza, Mohammadi, Rahim, Zarei, Leila. (1395). 'Assessment of Neuroprotective Effects of Local Administration of 17- Beta- Estradiol on Peripheral Nerve Regeneration in Ovariectomized Female Rats', سامانه مدیریت نشریات علمی, 4(Issue 3), pp. 141-149.
Nobakhti-Afshar, Ahmadreza, Najafpour, Alireza, Mohammadi, Rahim, Zarei, Leila. Assessment of Neuroprotective Effects of Local Administration of 17- Beta- Estradiol on Peripheral Nerve Regeneration in Ovariectomized Female Rats. سامانه مدیریت نشریات علمی, 1395; 4(Issue 3): 141-149.

Assessment of Neuroprotective Effects of Local Administration of 17- Beta- Estradiol on Peripheral Nerve Regeneration in Ovariectomized Female Rats

Bulletin of Emergency And Trauma
مقاله 6، دوره 4، Issue 3، مهر 2016، صفحه 141-149    اصل مقاله (1.25 M)
نویسندگان
Ahmadreza Nobakhti-Afshar1؛ Alireza Najafpour1؛ Rahim Mohammadi* 2؛ Leila Zarei3
1Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran
2Department of Internal Medicine and Clinical Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
3Solid Tumor Research Center, Urmia University of Medical Sciences, Urmia, Iran.
چکیده
Objective: To assess the neuroprotective effects of local administration of 17- beta- estradiol on nerve regeneration.Methods: Sixty female Wistar rats were overiectomized and divided into four experimental groups (n = 15), randomly: In autograft group a segment of sciatic nerve was transected and re-implanted reversely. In sham-surgery group sciatic nerve was exposed and manipulated. In transected group left sciatic nerve was transected and stumps were fixed in adjacent muscle. In treatment group defect was bridged using a silicon conduit filled with 10 µL (0.1 mg/mL) 17- beta- estradiol. Each group was subdivided into four subgroups of five animals each and nerve fibers were studied in a 12-week period.Results: Behavioral, functional, biomechanical, electrophysiological and gastrocnemius muscle mass findings and morphometric indices confirmed faster recovery of regenerated axons in treatment group than in other groups (p<0.05). Immunohistochemical reactions to S-100 in treatment group were more positive than that in other groups.Conclusion: Local administration of 17-beta-estradiol improved functional recovery and morphometric indices of sciatic nerve. It could have clinical implications for the surgical management of patients after facial nerve transection.
کلیدواژه‌ها
Nerve regeneration؛ Sciatic nerve؛ 17-beta-estradiol؛ Local administration؛ Rat
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