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Mohammadi, Rahim, Mehrtash, Moein, Mehrtash, Moeid, Hassani, Nava, Hassanpour, Ali. (1394). Effect of Platelet Rich Plasma Combined with Chitosan Biodegradable Film on Full-Thickness Wound Healing in Rat Model. سامانه مدیریت نشریات علمی, 4(Issue 1), 29-37.
Rahim Mohammadi; Moein Mehrtash; Moeid Mehrtash; Nava Hassani; Ali Hassanpour. "Effect of Platelet Rich Plasma Combined with Chitosan Biodegradable Film on Full-Thickness Wound Healing in Rat Model". سامانه مدیریت نشریات علمی, 4, Issue 1, 1394, 29-37.
Mohammadi, Rahim, Mehrtash, Moein, Mehrtash, Moeid, Hassani, Nava, Hassanpour, Ali. (1394). 'Effect of Platelet Rich Plasma Combined with Chitosan Biodegradable Film on Full-Thickness Wound Healing in Rat Model', سامانه مدیریت نشریات علمی, 4(Issue 1), pp. 29-37.
Mohammadi, Rahim, Mehrtash, Moein, Mehrtash, Moeid, Hassani, Nava, Hassanpour, Ali. Effect of Platelet Rich Plasma Combined with Chitosan Biodegradable Film on Full-Thickness Wound Healing in Rat Model. سامانه مدیریت نشریات علمی, 1394; 4(Issue 1): 29-37.

Effect of Platelet Rich Plasma Combined with Chitosan Biodegradable Film on Full-Thickness Wound Healing in Rat Model

Bulletin of Emergency And Trauma
مقاله 4، دوره 4، Issue 1، فروردین 2016، صفحه 29-37    اصل مقاله (1.92 M)
نویسندگان
Rahim Mohammadi* 1؛ Moein Mehrtash2؛ Moeid Mehrtash2؛ Nava Hassani2؛ Ali Hassanpour3
1Department of Internal Medicine and Clinical Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
2Department of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
3Department of Mechanical Engineering of Biosystems, Faculty of Agriculture, Urmia University, Urmia, Iran
چکیده
Objective: To assess the effects of platelet rich plasma (PRP) with chitosan biodegradable film on full thickness wound healing in rat.Methods: This was an experimental study being performed in 2015 during a 4-month period. Twenty-four male white Wistar rats were divided into four groups of 12 rats each, randomly: Control group (SHAM) with creation of wounds and no treatment, PRP group with creation of wounds and application of one milliliter PRP, Chitosan group (CHIT) with dressing the wound with chitosan and CHIT/PRP group with application of one mL PRP and dressing the wound with chitosan. The wounds were created by cutting healthy skin. Wound size was measured on 6, 9, 12, 15, 18 and 21 post surgery and was compared between groups.Results: Reduction in wound area, hydroxyproline contents and biomechanical parameters indicated there was significant difference (p=0.001) between group CHIT/PRP and other groups. Biomechanical testing was performed on day 9 post surgery in incisional model. Quantitative histological studies and mean rank of the qualitative studies demonstrated that there was significant difference (p<0.001) between group CHIT/PRP and other groups.Conclusion: PRP with chitosan have beneficial effects on wounds repair and could be suggested for treating various types of wounds in animals and human being.
کلیدواژه‌ها
Chitosan؛ Platelet rich plasma (PRP)؛ Wound healing؛ Full-thickness wound
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