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Effects of Human Erythropoietin on Functional Outcome of Patients with Traumatic Cervical Cord Injury; A Pilot Randomized Clinical Trial | ||
| Bulletin of Emergency And Trauma | ||
| مقاله 2، دوره 3، Issue 3، مهر 2015، صفحه 79-85 اصل مقاله (925.16 K) | ||
| نویسندگان | ||
| EhsanAli Alibai؛ Fahim Baghban* ؛ Majid Reza Farrokhi؛ Navideh Mohebali؛ Mohammad Hossein Ashraf | ||
| Department of Neurosurgery Shiraz Neurosciences Research Center Shiraz University of Medical Sciences | ||
| چکیده | ||
| Objective: To determine the effects of recombinant human erythropoietin (rhEPO) on functional outcome and disability of patients with traumatic cervical spinal cord injury (SCI). Methods: This was a randomized, double blind, placebo controlled clinical trial being performed in Nemazee and Shahid Rajaei hospitals of Shiraz during a 3-year period from 2011 to 2014. A total number of 20 patients with acute traumatic cervical SCI less than 8 hours after injury were included. We excluded those with anatomic cord dissection, penetrating cord injury and significant concomitant injury. Patients were randomly assigned to receive rhEPO in 500IU/mL dosage immediately and 24-hour later (n=11) or placebo (n=9). All the patient received standard regimen of methylprednisolone. Neurological function was assessed on admission, 1, 6 and 12 months after the injury according to the American Spinal Cord Injury Association (ASIA).Results: Overall we include a total number of 20 patients. The mean age of the patients was found to be 40.1 ± 9.5 (ranging from 19 to 59) years. There were 18 (90.0%) men and 2 (10.0%) women among the patients. There was no significant difference between two study groups regarding the baseline characteristics. The baseline ASIA score was comparable between two study groups. The motor and sensory ASIA scores were comparable between two study groups after 1, 6 and 12 months follow-ups. We also found that there was no significant difference between two study groups regarding the motor and sensory outcome in complete cord injury and incomplete cord injury subgroups. Conclusion: Administration of rhEPO does not improve the functional outcome of patients with traumatic cervical SCI.Clinical trial registration: The study has been registered with Iranian Registry for Clinical Trials (www.irct.ir; IRCT2014122920471N1) | ||
| کلیدواژهها | ||
| Erythropoietin؛ Cervical cord injury؛ Functional outcome؛ Disability؛ Neuroprotective effect | ||
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آمار تعداد مشاهده مقاله: 921 تعداد دریافت فایل اصل مقاله: 422 |
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