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Mohammed, Nidhal Abdulmohaimen, Qassem, Haitham, Hassen, Farouk. (1392). Association between HLA-Class I and HLA-Class II Alleles and Mycobacterium Tuberculosis Infection in Iraqi Patients from Baghdad City. سامانه مدیریت نشریات علمی, 39(March Supplement), 191-195.
Nidhal Abdulmohaimen Mohammed; Haitham Qassem; Farouk Hassen. "Association between HLA-Class I and HLA-Class II Alleles and Mycobacterium Tuberculosis Infection in Iraqi Patients from Baghdad City". سامانه مدیریت نشریات علمی, 39, March Supplement, 1392, 191-195.
Mohammed, Nidhal Abdulmohaimen, Qassem, Haitham, Hassen, Farouk. (1392). 'Association between HLA-Class I and HLA-Class II Alleles and Mycobacterium Tuberculosis Infection in Iraqi Patients from Baghdad City', سامانه مدیریت نشریات علمی, 39(March Supplement), pp. 191-195.
Mohammed, Nidhal Abdulmohaimen, Qassem, Haitham, Hassen, Farouk. Association between HLA-Class I and HLA-Class II Alleles and Mycobacterium Tuberculosis Infection in Iraqi Patients from Baghdad City. سامانه مدیریت نشریات علمی, 1392; 39(March Supplement): 191-195.

Association between HLA-Class I and HLA-Class II Alleles and Mycobacterium Tuberculosis Infection in Iraqi Patients from Baghdad City

Iranian Journal of Medical Sciences
مقاله 5، دوره 39، March Supplement، خرداد 2014، صفحه 191-195    اصل مقاله (274.98 K)
نوع مقاله: Original Article(s)
نویسندگان
Nidhal Abdulmohaimen Mohammed* 1؛ Haitham Qassem2؛ Farouk Hassen3
1Department of Microbiology, Al-Nahrain College of Medicine, Al-Nahrain University, Baghdad, Iraq
2Microbiologist, College of Pharmacy, Al Mustansiyria University, Baghdad, Iraq
3Department of Microbiology, College of Medicine, Al Mustansiyria University, Baghdad, Iraq
چکیده
Background: Pulmonary tuberculosis (PT) is one of the endemic diseases in Iraq, and among the suggested predisposing factors are alleles of the human leukocyte antigen (HLA) system. We sought to investigate the association between HLA-class I (A and B) and -class II (DR and DQ) alleles in a sample of PT Iraqi patients.Methods: lymphocytes of 105 PT patients and 40 controls were phenotyped for HLA-A, -B, -DR, and -DQ alleles by means of the microlymphocytotoxicity test using a panel of monoclonal antisera. Results: HLA frequencies of B18 (16.2 vs. 2.5%; OD=7.53) and DR1 (51.4 vs. 10.0%; OD=9.53) alleles were significantly increased in the patients as compared with the controls, while B5 (6.7 vs. 25.0%), DR8 (1.9 vs. 17.5%), and DQ3 (11.4 vs. 45.0%) alleles were significantly decreased. However, a significant corrected level was maintained for only DR1, DR8, and DQ3 alleles (Pc=1.9×10-5, 0.02 and 1.0×10-4, respectively).Conclusion: The results confirm the predisposing and protecting roles of HLA alleles in PT.
کلیدواژه‌ها
Tuberculosis؛ MHC-Class I؛ MHC-Class II؛ Lymphocytotoxicity
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