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Reactivation of Cytomegalovirus in a Patient with Stevens-Johnson Syndrome-Toxic Epidermal Necrolysis | ||
Iranian Journal of Medical Sciences | ||
مقاله 10، دوره 38، June Supplement 2013، فروردین 2013، صفحه 195-197 اصل مقاله (181.81 K) | ||
نوع مقاله: Case Report(s) | ||
نویسندگان | ||
Mohamed Rida Tagajdid* 1؛ Taoufik Doblali1؛ Hicham Elannaz1؛ Salaheddine Hammi2؛ Bouchra Belfequih1؛ Saâd Mrani1 | ||
1Laboratory of Virology, Mohamed V Souissi University, Mohamed V Military Teaching Hospital, Rabat, BP, Morocco | ||
2Department of Internal Medicine, Mohamed V Military Teaching Hospital, Rabat, BP, Morocco | ||
چکیده | ||
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe adverse cutaneous reactions to drugs. We describe the case of a 19 year old patient with SJS/TEN overlap syndrome, who developed severe interstitial pneumonia after she had received antiepileptic drugs. A cytomegalovirus infection was diagnosed by Real Time Polymerase Chain Reaction (RT-PCR) detection on Bronchoalveolar lavage. Based on observations on biological data, temporal relationship, and clinical features, it could be inferred that the reactivation of cytomegalovirus with viral replication can predispose a person to TEN-SJS. We discuss here, in the light of the current literature, the probable association between drug-induced SJS-TEN and fulminant reactivation of cytomegalovirus. | ||
کلیدواژهها | ||
Stevens-Johnson syndrome؛ Toxic epidermal necrolysis؛ Cytomegalovirus؛ Pneumonia | ||
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