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The relationship between E-cadherin and b-catenin expressions with histopathologic grading of squamous cell carcinoma | ||
| Journal of Dentistry | ||
| مقاله 11، دوره 13، Supplement-September-2012، آذر 2012، صفحه 473-486 اصل مقاله (419.53 K) | ||
| نوع مقاله: Original Article | ||
| نویسندگان | ||
| P. Deyhimi* 1؛ B. Karimi2 | ||
| 1Dept. of Oral & Maxillofacial, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, IRAN | ||
| 2Dept. of Oral & Maxillofacial Pathology, School of Dentistry, Ahvaz University of Medical Sciences, Ahvaz, IRAN | ||
| چکیده | ||
| Statement of Problem: E-cadherin is an inetrcellular adhesion molecule playing the important role in cell to cell adhesion in the epithelium. β-catenin is a cytoplasmic protein that directly binds to E-cadherin to connect it to the cytoskeleton. The first step in invasion of cancerous cells to adjacent tissues or metastasis is reduction of adhesion between tumoral cells.Purpose: The purpose of this study was to determine therelationship between different grades of scc with expression rate of E-cadherin and b-catenin and also to identify the correlation of expression of these markers with each other.Materials and Method: The sections of 60 formalin-fixed, paraffin-embedded biopsy specimens including 20 well differentiated, 20 moderately differentiated and 20 poorly differentiated squamous cell carcinoma were immunostained to determine the expressions of E-cadherin and b-catenin. Mann-whitney, Kruskal-Wallis and Wilcoxon tests were used to analyze the data.Result: The difference of the expression of E-cadherin and b-catenin was statistically significant in different grades of scc ( p < 0.001). But comparison of the expression of these markers in any histological grade separately did not show a significant difference ( p >0.05). Although regardless of differential grade of the tumor, expression of b-catenin was significantly entirely different from E-cadherin overally ( p =0.015). Conclusion: These findings suggested that expression of E-cadherin and b-catenin reduced in proportion to reduction of differential grade of scc and also reduction of the expression of E-cadherin and b-catenin was proportional to each other, although regardless of the degree of differentiation, expression of b-catenin was totally less than that of E-cadherin.Key words: Squamous cell Carcinoma, E-cadherin, β-catenin, Hhistopathologic grade | ||
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