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Behrouzkia, Zh, Zohdiaghdam, R, Khalkhali, H R, Mousavi, F. (1397). Evaluation of Gold Nanoparticle Size Effect on Dose Enhancement Factor in Megavoltage Beam Radiotherapy Using MAGICA Polymer Gel Dosimeter. سامانه مدیریت نشریات علمی, 9(1), 89-96. doi: 10.31661/jbpe.v9i1Feb.1019
Zh Behrouzkia; R Zohdiaghdam; H R Khalkhali; F Mousavi. "Evaluation of Gold Nanoparticle Size Effect on Dose Enhancement Factor in Megavoltage Beam Radiotherapy Using MAGICA Polymer Gel Dosimeter". سامانه مدیریت نشریات علمی, 9, 1, 1397, 89-96. doi: 10.31661/jbpe.v9i1Feb.1019
Behrouzkia, Zh, Zohdiaghdam, R, Khalkhali, H R, Mousavi, F. (1397). 'Evaluation of Gold Nanoparticle Size Effect on Dose Enhancement Factor in Megavoltage Beam Radiotherapy Using MAGICA Polymer Gel Dosimeter', سامانه مدیریت نشریات علمی, 9(1), pp. 89-96. doi: 10.31661/jbpe.v9i1Feb.1019
Behrouzkia, Zh, Zohdiaghdam, R, Khalkhali, H R, Mousavi, F. Evaluation of Gold Nanoparticle Size Effect on Dose Enhancement Factor in Megavoltage Beam Radiotherapy Using MAGICA Polymer Gel Dosimeter. سامانه مدیریت نشریات علمی, 1397; 9(1): 89-96. doi: 10.31661/jbpe.v9i1Feb.1019

Evaluation of Gold Nanoparticle Size Effect on Dose Enhancement Factor in Megavoltage Beam Radiotherapy Using MAGICA Polymer Gel Dosimeter

Journal of Biomedical Physics and Engineering
مقاله 10، دوره 9، شماره 1، فروردین و اردیبهشت 2019، صفحه 89-96    اصل مقاله (842.27 K)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v9i1Feb.1019
نویسندگان
Zh Behrouzkia1؛ R Zohdiaghdam* 2؛ H R Khalkhali3؛ F Mousavi4
1PhD of Medical Physics, Urmia University of Medical Science, School of Medicine, Urmia, Iran
2PhD of Medical Physics, Urmia University of Medical Science, School of Para Medicine, Urmia, Iran
3PhDs of Biostatics, Patient Safety Research Center, Urmia University of Medical Sciences, Urmia, Iran
4MSc in Medical Physics, Urmia University of Medical Science, School of Medicine, Urmia, Iran
چکیده
Background: Gold nanoparticles (GNPs) are among the most promising radiosensitive materials in radiotherapy. Studying the effective sensitizing factors such as nanoparticle size, concentration, surface features, radiation energy and cell type can help to optimize the effect and possible clinical application of GNPs in radiation therapy. In this study, the radiation sensitive polymer gel was used to investigate the dosimetric effect of GNP size in megavoltage (MV) photon beam radiotherapy.
Material and Methods: GNPs with the size of 30nm, 50nm and 100nm in diameter were used. Transmission electron microscope (TEM) and dynamic light scattering (DLS) were applied to analyze the size of nanoparticles. The MAGICA polymer gel was synthesized and impregnated with different sizes of GNPs. The samples were irradiated with 6MV photon beam and 24 hours after irradiation, they were read using a Magnetic Resonance Imaging (MRI) scanner. Macroscopic Dose Enhancement Factor (DEF) was measured to compare the effect of GNP size. The MAGICA response of the 6MV x-ray beam was verified comparing Percentage Depth Dose (PDD) curve extracted from polymer gel dosimetry and Treatment Planning System (TPS).
Results: MAGICA polymer gel dose response curve was linear in the range of 0 to 10 Gy. DEFs by adding 30nm, 50nm and 100nm GNPs were 1.1, 1.17 and 1.12, respectively. PDD curves of polymer gel dosimeter and treatment planning system were in good agreement.
Conclusion: The results indicated a substantial increase in DEF uses a MV photon beam in combination with GNPs of different sizes and it was inconsistent with previous radiobiological studies. The maximum DEF was achieved for 50nm GNPs in comparison with 30nm and 100nm leading to the assumption of self-absorption effect by larger diameters. According to the outcomes of this work, MAGICA polymer gel can be recommended as a reliable dosimeter to investigate the dosimetric effect of GNP size and also a useful method to validate the current radiobiological and simulation studies.
کلیدواژه‌ها
Gold Nanoparticle؛ Polymer Gel؛ Dosimetry؛ Radiotherapy
مراجع
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