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Effects of Orange, Tangerine, and Grapefruit Juices on Pharmacokinetic Parameters of Cyclosporine A in Rats | ||
| Iranian Journal of Medical Sciences | ||
| مقاله 11، دوره 32، شماره 1، خرداد 2007، صفحه 45-47 اصل مقاله (50.93 K) | ||
| نوع مقاله: Brief Report(s) | ||
| نویسندگان | ||
| Hadi Sorkhi* ؛ A.A. Moghadamnia؛ M. PourAmir؛ A.R. Firoozjahi؛ F. Oaliaee؛ H. Karbalaee Aghamolki | ||
| چکیده | ||
| This study was designed to investigate the effects of tangerine, orange, and grapefruit juice on the pharmacokinetic pattern of cyclosporine A in rats. Forty male Sprague-Dawley rats were divided into four groups to receive water, orange, tangerine, or grapefruit juices respectively. Water or juices (10 ml/kg) were given orally twice a day for 3 days. Three hours after the 5th dose, cyclosporine A was given as a single oral dose (5 mg/kg). Blood samples (2 ml) were collected at 30, 120, and 240 min after administering cyclosporine A, and area under time-concentration curve (AUC), Maximal serum concentration (Cmax),and time to reach maximal concentration (Tmax) were calculated using one-compartment method. Orange juice, but not tangerine or grapefruit juices, significantly increased the AUC and Cmax of cyclosporine A compared with water. The three juices significantly decreased the Tmax of cyclosporine A. The findings suggest that Thompson Novel's orange juice increased the bioavailability of oral administration of cyclosporine A formulation in rats. | ||
| کلیدواژهها | ||
| Pharmacokinetics؛ cyclosporine A؛ oranges؛ grapefruit | ||
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آمار تعداد مشاهده مقاله: 1,142 تعداد دریافت فایل اصل مقاله: 580 |
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