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Zabihzadeh, M, Moshirian, T, Ghorbani, M, Knaup, C, Behrooz, M A. (1396). A Monte Carlo Study on Dose Enhancement by Homogeneous and Inhomogeneous Distributions of Gold Nanoparticles in Radiotherapy with Low Energy X-rays. سامانه مدیریت نشریات علمی, 8(1), 13-28.
M Zabihzadeh; T Moshirian; M Ghorbani; C Knaup; M A Behrooz. "A Monte Carlo Study on Dose Enhancement by Homogeneous and Inhomogeneous Distributions of Gold Nanoparticles in Radiotherapy with Low Energy X-rays". سامانه مدیریت نشریات علمی, 8, 1, 1396, 13-28.
Zabihzadeh, M, Moshirian, T, Ghorbani, M, Knaup, C, Behrooz, M A. (1396). 'A Monte Carlo Study on Dose Enhancement by Homogeneous and Inhomogeneous Distributions of Gold Nanoparticles in Radiotherapy with Low Energy X-rays', سامانه مدیریت نشریات علمی, 8(1), pp. 13-28.
Zabihzadeh, M, Moshirian, T, Ghorbani, M, Knaup, C, Behrooz, M A. A Monte Carlo Study on Dose Enhancement by Homogeneous and Inhomogeneous Distributions of Gold Nanoparticles in Radiotherapy with Low Energy X-rays. سامانه مدیریت نشریات علمی, 1396; 8(1): 13-28.

A Monte Carlo Study on Dose Enhancement by Homogeneous and Inhomogeneous Distributions of Gold Nanoparticles in Radiotherapy with Low Energy X-rays

Journal of Biomedical Physics and Engineering
مقاله 3، دوره 8، شماره 1، خرداد 2018، صفحه 13-28    اصل مقاله (1.97 M)
نوع مقاله: Original Research
نویسندگان
M Zabihzadeh1، 2، 3؛ T Moshirian* 1؛ M Ghorbani4؛ C Knaup5؛ M A Behrooz1
1Department of Medical Physics, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2Departments of Clinical Oncology, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4Biomedical Engineering and Medical Physics Department, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada, USA
چکیده
Background: To enhance the dose to tumor, the use of high atomic number elements has been proposed.Objective: The aim of this study is to investigate the effect of gold nanoparticle distribution on dose enhancement in tumor when the tumor is irradiated by typical monoenergetic X-ray beams by considering homogeneous and inhomogeneous distributions of gold nanoparticles (GNPs) in the tumor.Methods: MCNP-4C Monte Carlo code was utilized for the simulation of a source, a phantom containing tumor and gold nanoparticles with concentrations of 10, 30 and 70 mg Au/g tumor. A 15 cm×15 cm×15 cm cubic water phantom was irradiated with a small planar source with four monoenergetic X-ray beams of 35, 55, 75 and 95 keV energy. Furthermore, tumor depths of 2.5 cm, 4.5 cm and 6.5 cm with homogeneous and inhomogeneous distributions of nanoparticles were studied. Each concentration, photon energy, tumor depth and type of distribution was evaluated in a separate simulation.Results: Results have shown that dose enhancement factor (DEF) in tumor increases approximately linearly with the concentration of gold nanoparticles. While DEF has fluctuations with photon energy, 55 keV photons have the highest DEF values compared to other energies. While DEF has relatively the same values with tumor located at various depths, inhomogeneous distribution of GNP has shown different results compared with the homogeneous model. Dose enhancement can be expected with relatively deep seated tumors in radiotherapy with low energy X-rays. Inhomogeneous model is recommended for the purpose of dose enhancement study because it mimics the real distribution of GNPs in tumor.
کلیدواژه‌ها
Gold Nanoparticle؛ Dose Enhancement؛ Homogeneous Distribution؛ Inhomogeneous Distribution؛ Monte Carlo Simulation
مراجع
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