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Rahgoshai, S, Mohammadi, M, Refahi, S, Oladghaffari, M, Aghamiri, S M R. (1396). Protective Effects of IMOD and Cimetidine against Radiation-induced Cellular Damage. سامانه مدیریت نشریات علمی, 8(1), 133-140.
S Rahgoshai; M Mohammadi; S Refahi; M Oladghaffari; S M R Aghamiri. "Protective Effects of IMOD and Cimetidine against Radiation-induced Cellular Damage". سامانه مدیریت نشریات علمی, 8, 1, 1396, 133-140.
Rahgoshai, S, Mohammadi, M, Refahi, S, Oladghaffari, M, Aghamiri, S M R. (1396). 'Protective Effects of IMOD and Cimetidine against Radiation-induced Cellular Damage', سامانه مدیریت نشریات علمی, 8(1), pp. 133-140.
Rahgoshai, S, Mohammadi, M, Refahi, S, Oladghaffari, M, Aghamiri, S M R. Protective Effects of IMOD and Cimetidine against Radiation-induced Cellular Damage. سامانه مدیریت نشریات علمی, 1396; 8(1): 133-140.

Protective Effects of IMOD and Cimetidine against Radiation-induced Cellular Damage

Journal of Biomedical Physics and Engineering
مقاله 14، دوره 8، شماره 1، خرداد 2018، صفحه 133-140    اصل مقاله (311.1 K)
نوع مقاله: Blackboard
نویسندگان
S Rahgoshai1؛ M Mohammadi* 1؛ S Refahi2؛ M Oladghaffari3؛ S M R Aghamiri4
1Department of Medical radiation Science, School of Paramedicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2Assistant Professor of Medical Physics, Department of Medical Physics, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
3Cellular & Molecular Biology Research Center, Medical Physics Department, Faculty of medicine, Babol University of Medical Sciences, Babol, Iran
4Department of Radiation Medicine, Shahid Beheshti University of Medical Sciences,Tehran, Iran
چکیده
Radiation damage is to a large extent caused by overproduction of reactive oxygen species (ROS). Radioprotectors are agents or substances that reduce the effects of radiation in healthy normal tissues while maintaining the sensitivity to radiation damage in tumor cells.
Radioprotectors are agents or substances that reduce the effects of radiation in healthy normal tissues while maintaining the sensitivity to radiation damage in tumor cells
Cimetidine was found more effective when used in vivo; this effect might be due to the augmentation of the presence of Sulphur atom in the compound which is ‎important for their scavenging activity.
Recently, a new herbal-based medicine with immunomodulatory capacities, Setarud (IMOD), was introduced as an additional therapy in various inflammatory diseases and HIV infection.
IMOD is a mixture of herbal extracts enriched with selenium. Selenium confers protection by inducing or activating cellular free-radical scavenging systems and by enhancing peroxide breakdown. This article suggests that nontoxic amount of IMOD and cimetidine have radioprotective properties and could reduce cytotoxic effects of radiation.
کلیدواژه‌ها
Radioprotection؛ Cimetidine؛ IMOD؛ Immunomodulator؛ Free Radical
مراجع
  1. Shukla SK, Gupta ML. Approach towards development of a radioprotector using herbal source against lethal irradiation. Int Res J Plant Sci. 2010;1:118-25.
  2. Islamian JP, Mohammadi M, Baradaran B. Inhibition of human esophageal squamous cell carcinomas by targeted silencing of tumor enhancer genes: an overview. Cancer Biol Med. 2014;11:78-85. PubMed PMID: 25009749. PubMed PMCID: 4069799.
  3. Weitzel DH, Tovmasyan A, Ashcraft KA, Rajic Z, Weitner T, Liu C, et al. Radioprotection of the brain white matter by Mn(III) n-Butoxyethylpyridylporphyrin-based superoxide dismutase mimic MnTnBuOE-2-PyP5+. Mol Cancer Ther. 2015;14:70-9. doi.org/10.1158/1535-7163.MCT-14-0343. PubMed PMID: 25319393. PubMed PMCID: 4397941.
  4. Raafat Y, Eman N, El Omama S, Nadia F, Maha G. Evaluation of Anti-Oxidant Status and Radioprotective Activity of a Novel Anti-Cancer Drug in Mice. Journal of Cancer Therapy. 2011;2011.
  5. Said U, Azab K, Soliman A. Cardio protective role of garlic (Allium Sativum) against oxidative stress induced by gamma radiation exposure. Isotope and Radiation Research. 2004;36:465-79.
  6. Manea A, Fortuno A, Martin-Ventura JL. Oxidative stress in cardiovascular pathologies: genetics, cellular, and molecular mechanisms and future antioxidant therapies. Oxid Med Cell Longev. 2012;2012:373450. doi.org/10.1155/2012/373450. PubMed PMID: 23346282. PubMed PMCID: 3549365.
  7. Liu W, Chen Q, Wu S, Xia X, Wu A, Cui F, et al. Radioprotector WR-2721 and mitigating peptidoglycan synergistically promote mouse survival through the amelioration of intestinal and bone marrow damage. J Radiat Res. 2015;56:278-86. doi.org/10.1093/jrr/rru100. PubMed PMID: 25617317. PubMed PMCID: 4380048.
  8. Naruka K, Bhartiya HC. Protection of bone marrow of Swiss albino mouse against whole body gamma irradiation by WR-2721. Indian J Exp Biol. 1992;30:535-7. PubMed PMID: 1324228.
  9. Momm F, Bechtold C, Fischer K, Tsekos A, Henke M. Alteration of radiation-induced hematotoxicity by amifostine (ethyol). Strahlenther Onkol. 1999;175:2-5. doi.org/10.1007/BF03215919. PubMed PMID: 10584132.
  10. Soref CM, Hacker TA, Fahl WE. A new orally active, aminothiol radioprotector-free of nausea and hypotension side effects at its highest radioprotective doses. Int J Radiat Oncol Biol Phys. 2012;82:e701-7. doi.org/10.1016/j.ijrobp.2011.11.038. PubMed PMID: 22330992.
  11. San Segundo CG, Manuel FAC. Radioprotectors. Revista de Oncología. 2002;4:277-83.
  12. Xu P, Zhang WB, Cai XH, Lu DD, He XY, Qiu PY, et al. Flavonoids of Rosa roxburghii Tratt act as radioprotectors. Asian Pac J Cancer Prev. 2014;15:8171-5. doi.org/10.7314/APJCP.2014.15.19.8171. PubMed PMID: 25339001.
  13. Kma L. Plant extracts and plant-derived compounds: promising players in a countermeasure strategy against radiological exposure. Asian Pac J Cancer Prev. 2014;15:2405-25. doi.org/10.7314/APJCP.2014.15.6.2405. PubMed PMID: 24761841.
  14. Brizel DM, Wasserman TH, Henke M, Strnad V, Rudat V, Monnier A, et al. Phase III randomized trial of amifostine as a radioprotector in head and neck cancer. J Clin Oncol. 2000;18:3339-45. PubMed PMID: 11013273.
  15. Yamini K, Gopal V. Natural radioprotective agents against ionizing radiation–an overview. International Journal of PharmTech Research. 2010;2:1421-6.
  16. Baliga MS, Rao S. Radioprotective potential of mint: a brief review. J Cancer Res Ther. 2010;6:255-62. doi.org/10.4103/0973-1482.73336. PubMed PMID: 21119249.
  17. G CJ. Radioprotective Potential of Plants and Herbs against the Effects of Ionizing Radiation. J Clin Biochem Nutr. 2007;40:74-81. doi.org/10.3164/jcbn.40.74. PubMed PMID: 18188408. PubMed PMCID: 2127223.
  18. Chaterjee A, Pakrashi S. Annona squamosa in the treatise of Indian medicinal plants Publication and Information Directorate. New Delhi. 1995;130.
  19. Bhattacharya S, Subramanian M, Roychowdhury S, Bauri AK, Kamat JP, Chattopadhyay S, et al. Radioprotective property of the ethanolic extract of Piper betel Leaf. J Radiat Res. 2005;46:165-71. doi.org/10.1269/jrr.46.165. PubMed PMID: 15988134.
  20. Bhattacharjee S. Reactive oxygen species and oxidative burst: roles in stress, senescence and signal. Curr Sci. 2005;89:1113-21.
  21. Zangeneh M, Mozdarani H, Mahmoudzadeh A, Aghamiri MR. Effects of famotidine and vitamin C on low dose radiation-induced micronuclei in mice bone marrow cells. Journal of Paramedical Sciences. 2015;5(4).
  22. Xu P, Jiang EJ, Wen SY, Lu DD. Amentoflavone acts as a radioprotector for irradiated v79 cells by regulating reactive oxygen species (ROS), cell cycle and mitochondrial mass. Asian Pac J Cancer Prev. 2014;15:7521-6. doi.org/10.7314/APJCP.2014.15.18.7521. PubMed PMID: 25292022.
  23. Mahdavi M, Mozdarani H. Protective effects of famotidine and vitamin C against radiation induced cellular damage in mouse spermatogenesis process. Iran J Radiat Res. 2011;8:223-30.
  24. Mozdarani H, Salimi M, Froughizadeh M. Effect of cimetidine and famotidine on survival of lethally gamma irradiated mice. Iran J Radiat Res. 2008;5:187-94.
  25. Du XX, Zhou YJ, Xu YH. Effects of histamine H2-receptor antagonists on hemopoietic reconstruction in bone marrow. Sheng Li Xue Bao. 1989;41:597-601. PubMed PMID: 2576333.
  26. Hast R, Bernell P, Hansson M. Cimetidine as an immune response modifier. Med Oncol Tumor Pharmacother. 1989;6:111-3. PubMed PMID: 2657245.
  27. Marshall ME, Conley D, Hollingsworth P, Brown S, Thompson JS. Effects of coumarin (1,2-benzopyrone) on lymphocyte, natural killer cell, and monocyte functions in vitro. J Biol Response Mod. 1989;8:70-85. PubMed PMID: 2921611.
  28. Mozdarani H, Gharbali A. Radioprotective effects of cimetidine in mouse bone marrow cells exposed to gamma-rays as assayed by the micronucleus test. Int J Radiat Biol. 1993;64:189-94. doi.org/10.1080/09553009314551291. PubMed PMID: 8103543.
  29. Mozdarani H, Khoshbin-Khoshnazar AR. In vivo protection by cimetidine against fast neutron-induced micronuclei in mouse bone marrow cells. Cancer Lett. 1998;124:65-71. doi.org/10.1016/S0304-3835(97)00451-5. PubMed PMID: 9500193.
  30. Mozdarani H, J Vessal N. Cimetidine can modify the effects of whole body’y-irradiation on ly mphohem atopoietic system. Medical Journal of the Islamic Republic of Iran (MJIRI). 1993;7:95-9.
  31. Lapenna D, De Gioia S, Mezzetti A, Grossi L, Festi D, Marzio L, et al. H2-receptor antagonists are scavengers of oxygen radicals. Eur J Clin Invest. 1994;24:476-81. doi.org/10.1111/j.1365-2362.1994.tb02378.x. PubMed PMID: 7957505.
  32. Ardestani SK, Janlow MM, Tavakoli AKZ. Effect of cimetidine and ranitidine on lipid profile and lipid peroxidation in γ-irradiated mice. Acta Medica Iranica. 2004;42:198-204.
  33. SeyedAlinaghi S, Paydary K, Emamzadeh-Fard S, Mohraz M. Treatment with IMODTM as a novel immune modulator in HIV positive patients. Journal of AIDS & Clinical Research. 2012;2012.
  34. Mirzaee S, Drewniak A, Sarrami-Forooshani R, Kaptein TM, Gharibdoost F, Geijtenbeek TB. Herbal medicine IMOD suppresses LPS-induced production of proinflammatory cytokines in human dendritic cells. Front Pharmacol. 2015;6:64. doi.org/10.3389/fphar.2015.00064. PubMed PMID: 25870561. PubMed PMCID: 4375992.
  35. Farhoudi M, Najafi-Nesheli M, Hashemilar M, Mahmoodpoor A, Sharifipour E, Baradaran B, et al. Effect of IMOD on the inflammatory process after acute ischemic stroke: a randomized clinical trial. Daru. 2013;21:26. doi.org/10.1186/2008-2231-21-26. PubMed PMID: 23514014. PubMed PMCID: 3620936.
  36. Mohraz M, Sedaghat A, SeyedAlinaghi S, Asheri H, Mohammaddoust S, Gharibdoost F, et al. Post marketing surveillance on safety and efficacy of IMOD in Iranian patients with HIV/AIDS. Infect Disord Drug Targets. 2013;13:71-4. doi.org/10.2174/18715265112129990031. PubMed PMID: 23713668.
  37. Arastoo M, Khorshid HRK, Radmanesh R, Gharibdoust F. Combination of IMOD™ and Arbidol to increase their immunomodulatory effects as a novel medicine to prevent and cure influenza and some other infectious diseases. Journal of Medical Hypotheses and Ideas. 2014;8:53-6. doi.org/10.1016/j.jmhi.2014.02.001.
  38. Novitsky YA, Madani H, Gharibdoust F, Farhadi M, Farzamfar B, Mohraz M. Use of a combination of ethanolic rosa sp., urtica dioica and tanacetum vulgare extracts, further compromising selenium and urea and having been exposed to a pulsed electromagnetic field, for the preparation of a medicament for immunostimulation and/or treatment of hiv infections. Google Patents. 2009.
  39. Schnittman SM, Greenhouse JJ, Psallidopoulos MC, Baseler M, Salzman NP, Fauci AS, et al. Increasing viral burden in CD4+ T cells from patients with human immunodeficiency virus (HIV) infection reflects rapidly progressive immunosuppression and clinical disease. Ann Intern Med. 1990;113:438-43. doi.org/10.7326/0003-4819-113-6-438. PubMed PMID: 1974752.
  40. Ren F, Chen X, Hesketh J, Gan F, Huang K. Selenium promotes T-cell response to TCR-stimulation and ConA, but not PHA in primary porcine splenocytes. PLoS One. 2012;7:e35375. doi.org/10.1371/journal.pone.0035375. PubMed PMID: 22530011. PubMed PMCID: 3328446.
  41. Rayman MP. The importance of selenium to human health. Lancet. 2000;356:233-41. doi.org/10.1016/S0140-6736(00)02490-9. PubMed PMID: 10963212.
  42. Cicek E, Yildiz M, Delibas N, Bahceli S. The effects of 201Tl myocardial perfusion scintigraphy studies on oxidative damage in patients. West Indian Med J. 2009;58:50-3. PubMed PMID: 19565998.
  43. Cicek E, Yildiz M, Delibas N, Bahceli S. The effects of thyroid scintigraphy studies on oxidative damage in patients. Acta Physiol Hung. 2006;93:131-6. doi.org/10.1556/APhysiol.93.2006.2-3.3. PubMed PMID: 17063624.
  44. Ozturk P, Arican O, Belge Kurutas E, Karakas T, Kabakci B. Oxidative stress in patients with scalp seborrheic dermatitis. Acta Dermatovenerol Croat. 2013;21:80-5. PubMed PMID: 24001414.
  45. Razzaghdoust A, Mozdarani H, Mofid B, Aghamiri SM, Heidari AH. Reduction in radiation-induced lymphocytopenia by famotidine in patients undergoing radiotherapy for prostate cancer. Prostate. 2014;74:41-7. doi.org/10.1002/pros.22725. PubMed PMID: 24019126.
  46. Ghorbani M, Mozdarani H. In vitro radioprotective effects of histamine H2 receptor antagonists against gamma-rays induced chromosomal aberrations in human lymphocytes. Iran J Radiat Res. 2003;1:99-104.
  47. Ching TL, Haenen GR, Bast A. Cimetidine and other H2 receptor antagonists as powerful hydroxyl radical scavengers. Chem Biol Interact. 1993;86:119-27. doi.org/10.1016/0009-2797(93)90116-G. PubMed PMID: 8095439.
  48. Mozdarani H. Radioprotective properties of histamine H2 receptor antagonists: present and future prospects. J Radiat Res. 2003;44:145-9. doi.org/10.1269/jrr.44.145. PubMed PMID: 13678344.
  49. Xian L, Lou M, Wu X, Yu B, Frassica F, Wan M, et al. Pretreatment with antioxidants prevent bone injury by improving bone marrow microenvironment for stem cells. Stem Cell Discovery. 2012;2:100.
  50. SShajiei A, Saadati M, Khalil Bahmani M, Doroudian M. The Novel Study of IMOD TM against HIV-1, P24production. Int J Mol Clin Microbiol. 2011;1:60–4.
  51. Nair CK, Parida DK, Nomura T. Radioprotectors in radiotherapy. J Radiat Res. 2001;42:21-37. doi.org/10.1269/jrr.42.21. PubMed PMID: 11393887.
  52. Nair CK, Salvi V, Kagiya TV, Rajagopalan R. Relevance of radioprotectors in radiotherapy: studies with tocopherol monoglucoside. J Environ Pathol Toxicol Oncol. 2004;23:153-60. doi.org/10.1615/jenvpathtoxoncol.v23.i2.80. PubMed PMID: 15163294.
  53. Weiss JF, Hoover RL, Kumar KS. Selenium pretreatment enhances the radioprotective effect and reduces the lethal toxicity of WR-2721. Free Radic Res Commun. 1987;3:33-8. doi.org/10.3109/10715768709069767. PubMed PMID: 2854528.
  54. Patchen ML, MacVittie TJ, Weiss JF. Combined modality radioprotection: the use of glucan and selenium with WR-2721. Int J Radiat Oncol Biol Phys. 1990;18:1069-75. doi.org/10.1016/0360-3016(90)90442-M. PubMed PMID: 2161407.
  55. Badiello R, Fielden EM. Pulse radiolysis of selenium-containing radioprotectors. I. Selenourea. Int J Radiat Biol Relat Stud Phys Chem Med. 1970;17:1-14. doi.org/10.1080/09553007014550011. PubMed PMID: 5309092.
  56. Borek C, Ong A, Mason H, Donahue L, Biaglow JE. Selenium and vitamin E inhibit radiogenic and chemically induced transformation in vitro via different mechanisms. Proc Natl Acad Sci U S A. 1986;83:1490-4. doi.org/10.1073/pnas.83.5.1490. PubMed PMID: 3456598. PubMed PMCID: 323102.
  57. Schüller P, Püttmann S, Micke O, Senner V, Schäfer U, Willich N. Selenium-a novel radiosensitizer? Increased radiation sensitivity in C6 rat glioma cells incubated with different concentrations of selenite. Trace Elements & Electrolytes. 2005;22. doi.org/10.5414/tep22201.
  58. Micke O, Schomburg L, Buentzel J, Kisters K, Muecke R. Selenium in oncology: from chemistry to clinics. Molecules. 2009;14:3975-88. doi.org/10.3390/molecules14103975. PubMed PMID: 19924043.
  59. Micke O, Schomburg L, Buentzel J. Selenium in oncology: from chemistry to clinics. Alternative Medicine Review. 2010;15:90-1.
  60. Eroglu C, Unal D, Cetin A, Orhan O, Sivgin S, Ozturk A. Effect of serum selenium levels on radiotherapy-related toxicity in patients undergoing radiotherapy for head and neck cancer. Anticancer Res. 2012;32:3587-90. PubMed PMID: 22843950.
  61. Kupper FC, Kloareg B, Guern J, Potin P. Oligoguluronates elicit an oxidative burst in the brown algal kelp Laminaria digitata. Plant Physiol. 2001;125:278-91. doi.org/10.1104/pp.125.1.278. PubMed PMID: 11154336. PubMed PMCID: 61009.
  62. Joksic G, Ilic N, Spasojevic-Tisma V. Radioprotective properties of nutraceutical Gonebazol: In vivo study. Archive of Oncology. 2006;14:15. doi.org/10.2298/AOO0602015J.
  63. Ikushima T, Mortazavi SJ. Radioadaptive response: its variability in cultured human lymphocytes. Biological Effects of Low Dose Radiation. Amsterdam: Elsevier. p. 2000:81-6.
  64. Petrovic S, Leskovac A, Joksic G. Positive correlation between micronuclei and necrosis of lymphocytes in medical personnel occupationally exposed to ionizing radiation. Part of Oncology. 2005;13:65. doi.org/10.2298/aoo0502065p.
  65. Shahidi M, Mozdarani H. Potent radioprotective effect of therapeutic doses of ranitidine and famotidine against gamma-rays induced micronuclei in vivo. Iran J Radiat Res. 2003;1:29-35.
  66. Mozdarani H, Nasirian B, Haeri SA. In vivo gamma-rays induced initial DNA damage and the effect of famotidine in mouse leukocytes as assayed by the alkaline comet assay. J Radiat Res. 2007;48:129-34. doi.org/10.1269/jrr.06055. PubMed PMID: 17299251.
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