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Mortazavi, S M J, Mostafavi-Pour, Z, Daneshmand, M, Zal, F, Zare, R, Mosleh-Shirazi, M A. (1396). Adaptive Response Induced by Pre-Exposure to 915 MHz Radiofrequency: A Possible Role for Antioxidant Enzyme Activity. سامانه مدیریت نشریات علمی, 7(2), 137-142.
S M J Mortazavi; Z Mostafavi-Pour; M Daneshmand; F Zal; R Zare; M A Mosleh-Shirazi. "Adaptive Response Induced by Pre-Exposure to 915 MHz Radiofrequency: A Possible Role for Antioxidant Enzyme Activity". سامانه مدیریت نشریات علمی, 7, 2, 1396, 137-142.
Mortazavi, S M J, Mostafavi-Pour, Z, Daneshmand, M, Zal, F, Zare, R, Mosleh-Shirazi, M A. (1396). 'Adaptive Response Induced by Pre-Exposure to 915 MHz Radiofrequency: A Possible Role for Antioxidant Enzyme Activity', سامانه مدیریت نشریات علمی, 7(2), pp. 137-142.
Mortazavi, S M J, Mostafavi-Pour, Z, Daneshmand, M, Zal, F, Zare, R, Mosleh-Shirazi, M A. Adaptive Response Induced by Pre-Exposure to 915 MHz Radiofrequency: A Possible Role for Antioxidant Enzyme Activity. سامانه مدیریت نشریات علمی, 1396; 7(2): 137-142.

Adaptive Response Induced by Pre-Exposure to 915 MHz Radiofrequency: A Possible Role for Antioxidant Enzyme Activity

Journal of Biomedical Physics and Engineering
مقاله 6، دوره 7، شماره 2، شهریور 2017، صفحه 137-142    اصل مقاله (414.03 K)
نوع مقاله: Original Research
نویسندگان
S M J Mortazavi1؛ Z Mostafavi-Pour* 2، 3؛ M Daneshmand4؛ F Zal5؛ R Zare2؛ M A Mosleh-Shirazi6
1Medical Physics and Medical Engineering Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
2Biochemistry Department, Medical School, Shiraz University of Medicinal Sciences, Shiraz, IR Iran
3Recombinant Protein Laboratory, School of Advanced Medical Sciences and Technologies, Shiraz University of Medicinal Sciences, Shiraz, Iran
4Radiology Department, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
5Reproductive Biology Department, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
6Radiation Physics Section, Radiotherapy, Namazi Teaching Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Over the past few years, the rapid use of high frequency electromagnetic fields like mobile phones has raised global concerns about the negative health effects of its use. Adaptive response is the ability of a cell or tissue to better resist stress damage by prior exposure to a lesser amount of stress. This study aimed to assess whether radiofrequency radiation can induce adaptive response by changing the antioxidant balance.Materials and Methods: In order to assess RF-induced adaptive response in tissues, we evaluated the level of GSH and the activity of GR in liver. 50 rats were divided into 5 groups. Three groups were pre-exposed to 915 MHz RF radiation, 4 hours per day for one week at different powers, as low, medium and high. 24 hours after the last exposure to radiation, they were exposed to 4 Gy sublethal dose of gamma radiation and then sacrificed after 5 hours. Their livers were removed, washed and were kept at -80o C until used.Results: Our finding showed that pre-exposure to 915 MHz radiofrequency radiation with specific power could induce adaptive response in liver by inducing changes in the activity and level of antioxidant enzymes.Conclusion: It can be concluded that pre-exposure to microwave radiation could increase the level of GSH and the activity of GR enzyme, although these increases were seen just in low power group, and the GR activity was indicated in medium power group. This increase protects tissue from oxidative damage induced by sublethal dose of gamma radiation.
کلیدواژه‌ها
Adaptive response؛ RF Radiation؛ Antioxidant Enzymes؛ Glutathione Reductase (GR)؛ Reduced Glutathione (GSH)
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