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Studying Effects of Gold Nanoparticle on Dose Enhancement in Megavoltage Radiation | ||
| Journal of Biomedical Physics and Engineering | ||
| مقاله 4، دوره 5، شماره 4، اسفند 2015 اصل مقاله (436.05 K) | ||
| نوع مقاله: Original Research | ||
| نویسندگان | ||
| M Khadem Abolfazli1؛ S R Mahdavi2؛ M Mahdavi3؛ Gh Ataei* 4 | ||
| 1Babol medical university | ||
| 2Iran Medical university | ||
| 3Mazandaran university | ||
| 4Babol Medical university | ||
| چکیده | ||
| Background: Gold nanoparticles are emerging as promising agents for cancer therapy and are being investigated as drug carriers, photothermal agents, contrast agents and radiosensitisers.Objective: The aim of this study is to understand characteristics of secondary electrons generated from interaction of gold nanoparticles GNPs with x-rays as a function of nanoparticle size and beam energy and thereby further understanding of GNP-enhanced radiotherapy. Methods: Effective range, defection angle, dose deposition, energy, and interaction processes of electrons produced from the interaction of x-rays with a GNP were calculated by Monte Carlo simulations. The MCNPX code was used to simulate and track electrons generated from 30 and 50 nm diameter GNP when it is irradiated with a cobalt-60 and 6MV photon and electron beam in water. Results: When a GNP was present, depending on beam types used, secondary electron production increased by 10- to 2000-fold compared to absence of a GNP. Conclusion: GNPs with larger diameters also contributed to more doses. | ||
| کلیدواژهها | ||
| MCNPX Code؛ Megavoltage Radiotherapy؛ Gold Nanoparticle؛ Dose Enhancement | ||
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آمار تعداد مشاهده مقاله: 576 تعداد دریافت فایل اصل مقاله: 140 |
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