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Cytokeratin: a Shortcut to Diagnose Spindle Cell Carcinoma | ||
| Journal of Dental Biomaterials | ||
| مقاله 6، دوره 4، شماره 3، آذر 2017، صفحه 450-453 اصل مقاله (215.47 K) | ||
| نوع مقاله: Case Report | ||
| نویسندگان | ||
| Ali Dehghani Nazhvani* 1؛ Pardis Haddadi2؛ Najmeh Sarafraz2؛ Fatemeh Faghihi3 | ||
| 1Department of Oral & Maxillofacial Pathology, Biomaterial Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| 2Postgraduate Student, Department of Periodontics, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| 3Postgraduate student, Department of Oral & Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| چکیده | ||
| A relatively rare subtype of squamous cell carcinoma (SCC) is spindle cell carcinoma (SPCC). It is composed of epithelium-derived spindle cells arranged in sheets with mesenchymal properties and small, hardly detectable regions of SCC, challenging its definite diagnosis. We encountered five cases of SPCC. In case one, chronic inflammation and subepithelial blister with leukoplakia was found 5 years before our examination. And later, exophytic features, keratotic papules and scar with elevated margins was seen on lateral border of the tongue. In case two, three and four, an abnormal soft tissue elevations were examined, and in the fifth case we examined the soft and bony specimen from the posterior aspect of maxillary ridge. We evaluated all of them histologically and immunohistochemically for cytokeratin to reach final diagnosis. | ||
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