LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,149
تعداد مقالات10,518
تعداد مشاهده مقاله45,416,284
تعداد دریافت فایل اصل مقاله11,292,135
Emadi, Saeed, Meskini, Somaye, Maghbooli, Mehdi. (1395). The Blood Level of Leptin in Alzheimer’s Patients and Healthy Individuals. سامانه مدیریت نشریات علمی, 2(3), 262-267. doi: 10.18869/nrip.jamsat.2.3.262
Saeed Emadi; Somaye Meskini; Mehdi Maghbooli. "The Blood Level of Leptin in Alzheimer’s Patients and Healthy Individuals". سامانه مدیریت نشریات علمی, 2, 3, 1395, 262-267. doi: 10.18869/nrip.jamsat.2.3.262
Emadi, Saeed, Meskini, Somaye, Maghbooli, Mehdi. (1395). 'The Blood Level of Leptin in Alzheimer’s Patients and Healthy Individuals', سامانه مدیریت نشریات علمی, 2(3), pp. 262-267. doi: 10.18869/nrip.jamsat.2.3.262
Emadi, Saeed, Meskini, Somaye, Maghbooli, Mehdi. The Blood Level of Leptin in Alzheimer’s Patients and Healthy Individuals. سامانه مدیریت نشریات علمی, 1395; 2(3): 262-267. doi: 10.18869/nrip.jamsat.2.3.262

The Blood Level of Leptin in Alzheimer’s Patients and Healthy Individuals

Journal of Advanced Medical Sciences and Applied Technologies
مقاله 4، دوره 2، شماره 3، آذر 2016، صفحه 262-267    اصل مقاله (567.93 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.18869/nrip.jamsat.2.3.262
نویسندگان
Saeed Emadi1؛ Somaye Meskini1؛ Mehdi Maghbooli* 2
1Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan
2Zanjan University of Medical Sciences
چکیده
Background: Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by accumulation of extracellular amyloid-β plaques and intracellular neurofibrillary tangles tau protein. Obesity significantly increases the risk of developing AD. Leptin is a peptide hormone secreted by adipocytes. In the present study the serum levels of leptin in AD was evaluated. Material and method: This study was performed on 12 Alzheimer patients referred to Zanjan Vali-e-Asr Hospital, and 12 healthy individuals. Serum levels of leptin were measured by ELISA method. Results: Our results show that the level of leptin was significantly different in AD patients and control group. Considering the relationship between leptin levels and the age, oldest the patients, the lowest the levels of leptin hormone, in both male and female. Also, the severity of disease was related to the level of leptin hormone.  Conclusion: There presumably could be a cause and effect relationship between AD progress and reduction in the serum level of leptin. It may also point to the potential usage of measuring the leptin concentration in finding a biomarker for the disease.
کلیدواژه‌ها
Alzheimer's disease؛ Leptin؛ Central Nervous System؛ Endocrine
مراجع
  1. Fredman L, James, B. D., Johnson, T. J., Scholz, K. P., Weuve, J. Alzheimer’s Disease Facts and Figures,. Alzheimer’s & Dementia. 2012;8(2):131-68.
  2. Nigel MH. Alzheimer Disease Methods and protocols. Humana Press,
  3. Totowa, NJ. 2010;32:1-24.
  4. Gilbert DP, Tae, W. K. . Linking Lipids to Alzheimer’s Disease. Cholesteroland Beyond Nature Reviews. 2011;12:284- 96.
  5. Alexander K, Robert, P. Novel Insights for the Treatment of Alzheimer's Disease. . Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2011;35:373- 9.
  6. Dardeno TA, Chou, S. H., Moon, H.-S., Chamberland, J. P., Fiorenza, C. G., and Mantzoros, C. S. Leptin in Human Physiology And Therapeutics. Frontiers in Neuroendocrinology. 2010;31:377-93.
  7. Ahima RS, Flier JS. Leptin. Annual review of physiology. 2000;62(1):413-37.
  8. El-Haschimi K, and Lehnert, H. Leptin Resistance- or Why Leptin Fails to Work in Obesity. Experimental and Clinical Endocrinology and Diabetes. 2003;111:2-7.
  9. Holden KF, Lindquist K, Tylavsky FA, Rosano C, Harris TB, Yaffe K. Serum leptin level and cognition in the elderly: findings from the Health ABC Study. Neurobiology of Aging. 2009;30(9):1483-9.
  10. Gustafson DR. Adiposity hormones and dementia. Journal of the neurological sciences. 2010;299(1):30-4.
  11. Amitani M, Asakawa, A., Amitani, H., and Inui, A. The Role of Leptin in the Control of Insulin-Glucose Axis. Frontiers in Neuroscience. 2013;7:1-12.
  12. Lieb W, Beiser AS, Vasan RS, Tan ZS, Au R, Harris TB, et al. Association of plasma leptin levels with incident Alzheimer disease and MRI measures of brain aging. JAMA: the journal of the American Medical Association. 2009;302(23):2565-72.
  13. Signore AP, Zhang F, Weng Z, Gao Y, Chen J. Leptin neuroprotection in the CNS: mechanisms and therapeutic potentials. Journal of neurochemistry. 2008;106(5):1977-90.
  14. Greco SJ, Sarkar S, Johnston JM, Tezapsidis N. Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells. Biochemical and Biophysical Research Communications. 2009;380(1):98-104.
  15. Greco SJ, Sarkar S, Johnston JM, Zhu X, Su B, Casadesus G, et al. Leptin reduces Alzheimer’s disease-related tau phosphorylation in neuronal cells. Biochemical and Biophysical Research Communications. 2008;376(3):536-41.
  16. Niedowicz DM, Nelson PT, Murphy MP. Alzheimer’s disease: Pathological mechanisms and recent insights. Current neuropharmacology. 2011;9(4):674.
  17. Paz-Filho G, Wong M-L, Licinio J. Leptin Levels and Alzheimer Disease. JAMA 2010;15:1478-9.
  18. Lee EB. Obesity, leptin, and Alzheimer's disease. Annals of the New York Academy of Sciences. 2011;1243(1):15-29.
  19. Fewlass DC, Noboa K, Pi-Sunyer FX, Johnston JM, Yan SD, Tezapsidis N. Obesity-related leptin regulates Alzheimer’s Aβ. The FASEB journal. 2004;18(15):1870-8.
  20. Tezapsidis N, Johnston JM, Smith MA, Ashford JW, Casadesus G, Robakis NK, et al. Leptin: a novel therapeutic strategy for Alzheimer's disease. Journal of Alzheimer's Disease. 2009;16(4):731-40.
آمار
تعداد مشاهده مقاله: 2,611
تعداد دریافت فایل اصل مقاله: 499


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب