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Emadi, Saeed, Meskini, Somaye, Maghbooli, Mehdi. (1395). The Blood Level of Leptin in Alzheimer’s Patients and Healthy Individuals. سامانه مدیریت نشریات علمی, 2(3), 262-267. doi: 10.18869/nrip.jamsat.2.3.262
Saeed Emadi; Somaye Meskini; Mehdi Maghbooli. "The Blood Level of Leptin in Alzheimer’s Patients and Healthy Individuals". سامانه مدیریت نشریات علمی, 2, 3, 1395, 262-267. doi: 10.18869/nrip.jamsat.2.3.262
Emadi, Saeed, Meskini, Somaye, Maghbooli, Mehdi. (1395). 'The Blood Level of Leptin in Alzheimer’s Patients and Healthy Individuals', سامانه مدیریت نشریات علمی, 2(3), pp. 262-267. doi: 10.18869/nrip.jamsat.2.3.262
Emadi, Saeed, Meskini, Somaye, Maghbooli, Mehdi. The Blood Level of Leptin in Alzheimer’s Patients and Healthy Individuals. سامانه مدیریت نشریات علمی, 1395; 2(3): 262-267. doi: 10.18869/nrip.jamsat.2.3.262

The Blood Level of Leptin in Alzheimer’s Patients and Healthy Individuals

Journal of Advanced Medical Sciences and Applied Technologies
مقاله 4، دوره 2، شماره 3، آذر 2016، صفحه 262-267    اصل مقاله (567.93 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.18869/nrip.jamsat.2.3.262
نویسندگان
Saeed Emadi1؛ Somaye Meskini1؛ Mehdi Maghbooli* 2
1Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan
2Zanjan University of Medical Sciences
چکیده
Background: Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by accumulation of extracellular amyloid-β plaques and intracellular neurofibrillary tangles tau protein. Obesity significantly increases the risk of developing AD. Leptin is a peptide hormone secreted by adipocytes. In the present study the serum levels of leptin in AD was evaluated. Material and method: This study was performed on 12 Alzheimer patients referred to Zanjan Vali-e-Asr Hospital, and 12 healthy individuals. Serum levels of leptin were measured by ELISA method. Results: Our results show that the level of leptin was significantly different in AD patients and control group. Considering the relationship between leptin levels and the age, oldest the patients, the lowest the levels of leptin hormone, in both male and female. Also, the severity of disease was related to the level of leptin hormone.  Conclusion: There presumably could be a cause and effect relationship between AD progress and reduction in the serum level of leptin. It may also point to the potential usage of measuring the leptin concentration in finding a biomarker for the disease.
کلیدواژه‌ها
Alzheimer's disease؛ Leptin؛ Central Nervous System؛ Endocrine
مراجع
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