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Mirzaei, Esmaeil, Sarkar, Saeed, Rezayat, Seyed Mahdi, Faridi-Majidi, Reza. (1394). Herbal Extract Loaded Chitosan-Based Nanofibers as a Potential Wound-Dressing. سامانه مدیریت نشریات علمی, 2(1), 141-150. doi: 10.18869/nrip.jamsat.2.1.141
Esmaeil Mirzaei; Saeed Sarkar; Seyed Mahdi Rezayat; Reza Faridi-Majidi. "Herbal Extract Loaded Chitosan-Based Nanofibers as a Potential Wound-Dressing". سامانه مدیریت نشریات علمی, 2, 1, 1394, 141-150. doi: 10.18869/nrip.jamsat.2.1.141
Mirzaei, Esmaeil, Sarkar, Saeed, Rezayat, Seyed Mahdi, Faridi-Majidi, Reza. (1394). 'Herbal Extract Loaded Chitosan-Based Nanofibers as a Potential Wound-Dressing', سامانه مدیریت نشریات علمی, 2(1), pp. 141-150. doi: 10.18869/nrip.jamsat.2.1.141
Mirzaei, Esmaeil, Sarkar, Saeed, Rezayat, Seyed Mahdi, Faridi-Majidi, Reza. Herbal Extract Loaded Chitosan-Based Nanofibers as a Potential Wound-Dressing. سامانه مدیریت نشریات علمی, 1394; 2(1): 141-150. doi: 10.18869/nrip.jamsat.2.1.141

Herbal Extract Loaded Chitosan-Based Nanofibers as a Potential Wound-Dressing

Journal of Advanced Medical Sciences and Applied Technologies
مقاله 3، دوره 2، شماره 1، خرداد 2016، صفحه 141-150    اصل مقاله (940.56 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.18869/nrip.jamsat.2.1.141
نویسندگان
Esmaeil Mirzaei1؛ Saeed Sarkar2؛ Seyed Mahdi Rezayat2؛ Reza Faridi-Majidi* 3
1SAMST, SUMS
2Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
3Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran,
چکیده
Semelil is an herbal-based compound which is used for the treatment of chronic wounds, especially diabetic foot ulcers. On the other hand, Electrospun nanofibers have many characteristics such as mimicking extracellular matrix structure, efficiency as bacterial barrier, appropriate water vapor transmission rate, and provision of adequate gaseous exchange which make them ideal candidates for wound-healing application. The aim of this study was to incorporate Semelil in electrospun nanofibers to benefit both the advantages of Semelil and electrospun nanofibers for the treatment of wounds. To this aim, the blend solution of chitosan, polyethylene oxide (PEO) and the herbal extract were electrospun and chitosan-based nanofibers loaded with the herbal extract were fabricated. The as-spun fibers were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA). The swelling ratio and drug release behavior of the electrospun fibers were also studied. Uniform and bead-free nanofibrous mats loaded with 10-50 Wt. %extract were successfully fabricated. The FTIR spectrum indicated that the chemical nature of chitosan was not changed in the process of electrospinning. TGA analysis confirm both polymers and extract in electrospun mats. The extract loaded mats showed a high swelling ratio and a burst release of extract after 1h incubation in PBS. Mats with lower amount of drug exhibited graduate increase in the cumulative release of drug after initial burst release.
کلیدواژه‌ها
electrospinning؛ Nanofiber؛ Chitosan؛ Melilotus officinalis extract
مراجع
  1. Larijani B, Hasani Ranjbar S. OVERVIEW OF DIABETIC FOOT; NOVEL TREATMENTS IN DIABETIC FOOT ULCER. DURO. 2008;16(1):1-6.
  2. Khorram Khorshid HR, B S, Heshmat R, Abdollahi M, Salari P, Farzamfar B, et al. In vivo and in vitro genotoxicity studies of Semelil (ANGIPARSTM). DURO. 2008;16(1):20-4.
  3. Zhang Y, Lim C, Ramakrishna S, Huang Z-M. Recent development of polymer nanofibers for biomedical and biotechnological applications. J Mater Sci Mater Med. 2005;16(10):933-46.
  4. Zhong SP, Zhang YZ, Lim CT. Tissue scaffolds for skin wound healing and dermal reconstruction. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. 2010;2(5):510-25.
  5. Thakur RA, Florek CA, Kohn J, Michniak BB. Electrospun nanofibrous polymeric scaffold with targeted drug release profiles for potential application as wound dressing. Int J Pharm. 2008;364(1):87-93.
  6. Lee KY, Jeong L, Kang YO, Lee SJ, Park WH. Electrospinning of polysaccharides for regenerative medicine. Adv Drug Del Rev. 2009;61(12):1020-32.
  7. Faghihi F, Mirzaei E, Ai J, Lotfi A, Sayahpour FA, Barough SE, et al. Differentiation potential of human chorion-derived mesenchymal stem cells into motor neuron-like cells in two-and three-dimensional culture systems. Mol Neurobiol. 2015:1-11.
  8. Jayakumar R, Prabaharan M, Nair S, Tamura H. Novel chitin and chitosan nanofibers in biomedical applications. Biotechnol Adv. 2010;28(1):142-50.
  9. Taepaiboon P, Rungsardthong U, Supaphol P. Vitamin-loaded electrospun cellulose acetate nanofiber mats as transdermal and dermal therapeutic agents of vitamin A acid and vitamin E. Eur J Pharm Biopharm. 2007;67(2):387-97.
  10. Taepaiboon P, Rungsardthong U, Supaphol P. Drug-loaded electrospun mats of poly (vinyl alcohol) fibres and their release characteristics of four model drugs. Nanotechnology. 2006;17(9):2317.
  11. Kim K, Luu YK, Chang C, Fang D, Hsiao BS, Chu B, et al. Incorporation and controlled release of a hydrophilic antibiotic using poly (lactide-co-glycolide)-based electrospun nanofibrous scaffolds. J Controlled Release. 2004;98(1):47-56.
  12. Jarusuwannapoom T, Hongrojjanawiwat W, Jitjaicham S, Wannatong L, Nithitanakul M, Pattamaprom C, et al. Effect of solvents on electro-spinnability of polystyrene solutions and morphological appearance of resulting electrospun polystyrene fibers. Eur Polym J. 2005;41(3):409-21.
  13. Mit-uppatham C, Nithitanakul M, Supaphol P. Ultrafine Electrospun Polyamide-6 Fibers: Effect of Solution Conditions on Morphology and Average Fiber Diameter. Macromol Chem Phys. 2004;205(17):2327-38.
  14. Zong X, Kim K, Fang D, Ran S, Hsiao BS, Chu B. Structure and process relationship of electrospun bioabsorbable nanofiber membranes. Polymer. 2002;43(16):4403-12.
  15. Choi JS, Lee SW, Jeong L, Bae S-H, Min BC, Youk JH, et al. Effect of organosoluble salts on the nanofibrous structure of electrospun poly (3-hydroxybutyrate-< i> co-3-hydroxyvalerate). Int J Biol Macromol. 2004;34(4):249-56.
  16. Lee JS, Choi KH, Ghim HD, Kim SS, Chun DH, Kim HY, et al. Role of molecular weight of atactic poly(vinyl alcohol) (PVA) in the structure and properties of PVA nanofabric prepared by electrospinning. J Appl Polym Sci. 2004;93(4):1638-46.
  17. Demir MM, Yilgor I, Yilgor E, Erman B. Electrospinning of polyurethane fibers. Polymer. 2002;43(11):3303-9.
  18. Faridi‐Majidi R, Ziyadi H, Naderi N, Amani A. Use of artificial neural networks to determine parameters controlling the nanofibers diameter in electrospinning of nylon‐6, 6. J Appl Polym Sci. 2012;124(2):1589-97.
  19. Ayutsede J, Gandhi M, Sukigara S, Micklus M, Chen H-E, Ko F. Regeneration of Bombyx mori silk by electrospinning. Part 3: characterization of electrospun nonwoven mat. Polymer. 2005;46(5):1625-34.
  20. Zhao S, Wu X, Wang L, Huang Y. Electrospinning of ethyl–cyanoethyl cellulose/tetrahydrofuran solutions. J Appl Polym Sci. 2004;91(1):242-6.
  21. Lee JS, Choi KH, Ghim HD, Kim SS, Chun DH, Kim HY, et al. Role of molecular weight of atactic poly (vinyl alcohol)(PVA) in the structure and properties of PVA nanofabric prepared by electrospinning. J Appl Polym Sci. 2004;93(4):1638-46.
  22. De Vasconcelos C, Bezerril dP, Dos Santos D, Dantas dT, Pereira M, Fonseca J. Effect of molecular weight and ionic strength on the formation of polyelectrolyte complexes based on poly (methacrylic acid) and chitosan. Biomacromolecules. 2006;7(4):1245-52.
  23. Wan Y, Wu H, Yu A, Wen D. Biodegradable polylactide/chitosan blend membranes. Biomacromolecules. 2006;7(4):1362-72.
  24. Barat R, Srinatha A, Pandit J, Anupurba S, Mittal N. Chitosan inserts for periodontitis: influence of drug loading, plasticizer and crosslinking on in vitro metronidazole release. Acta Pharm. 2007;57(4):469-77.
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