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Tfayli, Arafat, Torabi-Nami, Mohammad, Ghotb, Atabak. (1394). Immunotherapy to Address Unmet Needs in Oncology; Two Clinical Vignettes of Response in Metastatic Malignant Melanoma and Non-Small Cell Lung Cancer. سامانه مدیریت نشریات علمی, 1(2), 116-119. doi: 10.18869/nrip.jamsat.1.2.116
Arafat Tfayli; Mohammad Torabi-Nami; Atabak Ghotb. "Immunotherapy to Address Unmet Needs in Oncology; Two Clinical Vignettes of Response in Metastatic Malignant Melanoma and Non-Small Cell Lung Cancer". سامانه مدیریت نشریات علمی, 1, 2, 1394, 116-119. doi: 10.18869/nrip.jamsat.1.2.116
Tfayli, Arafat, Torabi-Nami, Mohammad, Ghotb, Atabak. (1394). 'Immunotherapy to Address Unmet Needs in Oncology; Two Clinical Vignettes of Response in Metastatic Malignant Melanoma and Non-Small Cell Lung Cancer', سامانه مدیریت نشریات علمی, 1(2), pp. 116-119. doi: 10.18869/nrip.jamsat.1.2.116
Tfayli, Arafat, Torabi-Nami, Mohammad, Ghotb, Atabak. Immunotherapy to Address Unmet Needs in Oncology; Two Clinical Vignettes of Response in Metastatic Malignant Melanoma and Non-Small Cell Lung Cancer. سامانه مدیریت نشریات علمی, 1394; 1(2): 116-119. doi: 10.18869/nrip.jamsat.1.2.116

Immunotherapy to Address Unmet Needs in Oncology; Two Clinical Vignettes of Response in Metastatic Malignant Melanoma and Non-Small Cell Lung Cancer

Journal of Advanced Medical Sciences and Applied Technologies
مقاله 8، دوره 1، شماره 2، اسفند 2015، صفحه 116-119    اصل مقاله (279.88 K)
نوع مقاله: Case Study
شناسه دیجیتال (DOI): 10.18869/nrip.jamsat.1.2.116
نویسندگان
Arafat Tfayli1؛ Mohammad Torabi-Nami* 2؛ Atabak Ghotb3
1NK Basile Cancer Institute, American University of Beirut Medical Center, Beirut, Lebanon
2Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences
3Behphar Scientific Committee, Behphar Group, Tehran
چکیده
The management of unresectable advanced, metastatic malignant melanoma (MM) and chemotherapy-resistant or refractory non-small cell lung cancer (NSCLC) has been an uphill challenge in clinical oncology. The advent of immunotherapy in cancer has put forward some new hopes to cover unmet needs in treating such cases. Immune-checkpoint inhibitors are among the well-supported options in the same vein.  Alongside other cancer immunotherapy class-molecules, pembrolizumab (PZB), a programmed cell death protein 1 (PD-1) blocking antibody, has recently been approved both for MM and NSCLC. This report presents an overview of the clinical benefits of PZB in MM and NSCLC and highlights the clinical features of two eligible cases who have undergone immunotherapy using PZB. 
کلیدواژه‌ها
Malignant melanoma؛ NSCLC؛ Immunotherapy؛ Pembrolizumab؛ Clinical response
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