LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,149
تعداد مقالات10,518
تعداد مشاهده مقاله45,416,011
تعداد دریافت فایل اصل مقاله11,291,664
Mehdipour, Mohammad, Zarifkar, Asadollah, Namavar, Mohammad Reza. (1394). Evaluation of the Role of Melatonin in Dietary Restriction Effects on Spatial Memory Impairment Induced by Streptozotocin (STZ) in Male Rats. سامانه مدیریت نشریات علمی, 1(1), 42-50. doi: 10.18869/nrip.jamsat.1.1.42
Mohammad Mehdipour; Asadollah Zarifkar; Mohammad Reza Namavar. "Evaluation of the Role of Melatonin in Dietary Restriction Effects on Spatial Memory Impairment Induced by Streptozotocin (STZ) in Male Rats". سامانه مدیریت نشریات علمی, 1, 1, 1394, 42-50. doi: 10.18869/nrip.jamsat.1.1.42
Mehdipour, Mohammad, Zarifkar, Asadollah, Namavar, Mohammad Reza. (1394). 'Evaluation of the Role of Melatonin in Dietary Restriction Effects on Spatial Memory Impairment Induced by Streptozotocin (STZ) in Male Rats', سامانه مدیریت نشریات علمی, 1(1), pp. 42-50. doi: 10.18869/nrip.jamsat.1.1.42
Mehdipour, Mohammad, Zarifkar, Asadollah, Namavar, Mohammad Reza. Evaluation of the Role of Melatonin in Dietary Restriction Effects on Spatial Memory Impairment Induced by Streptozotocin (STZ) in Male Rats. سامانه مدیریت نشریات علمی, 1394; 1(1): 42-50. doi: 10.18869/nrip.jamsat.1.1.42

Evaluation of the Role of Melatonin in Dietary Restriction Effects on Spatial Memory Impairment Induced by Streptozotocin (STZ) in Male Rats

Journal of Advanced Medical Sciences and Applied Technologies
مقاله 6، دوره 1، شماره 1، آذر 2015، صفحه 42-50    اصل مقاله (663.18 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.18869/nrip.jamsat.1.1.42
نویسندگان
Mohammad Mehdipour1؛ Asadollah Zarifkar* 2؛ Mohammad Reza Namavar3
1Department of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Shiraz Neuroscience Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
3Histomorphometry and Stereology research center, Shiraz University of Medical Sciences, Shiraz, Iran; Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: It has been shown that dietary restriction in the form of every other day fasting (EODF) has neuroprotective effects. The mechanisms of these effects are unknown yet. Recently, it has claimed that dietary restriction can reset circadian and regulate irregular rhythms. Previous studies have demonstrated that dietary restriction can change melatonin production and secretion. Since melatonin has important role in circadian rhythms and its neuroprotective effect has been proved, it is reasonable that at least some dietary restriction effects may be due to the melatonin level changes. To investigate this hypothesis, melatonin receptors antagonist (Luzindole) was used in the rat model of Alzheimer’s disease. Material and Methods: Sixty four male rats were assigned into 8 groups which 4 groups had Ad libitum and 4 groups had every other day fasting (EODF) diet. Each group category comprised: 1-control group receiving only solvent of drugs, 2-group which received streptozotocin (STZ) at 3 mg/kg/icv,  3-group which received STZ at 3 mg/kg/icv and luzindole 50 µgr/kg/icv and 4-group which received STZ 3 mg/kg/icv and melatonin 10 mg/kg/ip. Dietary regimen continued for 10 days from the day cannulation was done in lateral ventricles. Spatial memory was evaluated by Morris water maze test. To evaluate the histological changes in the brain tissue, hematoxylin and eosin staining was used. Results: Based on Morris water maze test results, STZ could impair spatial memory in rats while dietary restriction did not improve memory impairment significantly. Likewise, melatonin and luzindole could not restore memory impairment. Histological study indicated that STZ destroyed the brain tissue in different parts including paraventricular zone, fornix, cortex and hippocampus which could be attributed to memory impairment. Counting dead neurons in CA1 part of the hippocampus showed that dietary restriction accompanied by exogenous melatonin with supra physiological dose, could partially improve STZ-induced impact in brain tissue. Conclusion: Melatonin appears not to retain an important role in the effects of dietary restriction on spatial memory impairment. Meanwhile, dietary restriction associated with exogenous melatonin seem to exert neuroprotective effects.
کلیدواژه‌ها
Dietary restriction؛ memory؛ circadian rhythm؛ melatonin؛ luzindole؛ hippocampus
مراجع
  1. Mattson, M.P., Energy intake, meal frequency, and health: a neurobiological perspective. Annu Rev Nutr, 2005; 25: 237-60.
  2. Qiu, G., S. Liu, and K.F. So, Dietary restriction and brain health. Neurosci Bull, 2010; 26(1): 55-65.
  3. Halagappa, V.K., et al., Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease. Neurobiol Dis, 2007; 26(1): 212-20.
  4. Mouton, P.R., et al., Caloric restriction attenuates amyloid deposition in middle-aged dtg APP/PS1 mice. Neurosci Lett, 2009; 464(3): 184-7.
  5. Fontan-Lozano, A., et al., Caloric restriction increases learning consolidation and facilitates synaptic plasticity through mechanisms dependent on NR2B subunits of the NMDA receptor. J Neurosci, 2007; 27(38): 10185-95.
  6. Lee, J., K.B. Seroogy, and M.P. Mattson, Dietary restriction enhances neurotrophin expression and neurogenesisin the hippocampus of adult mice. J Neurochem, 2002; 80(3): 539-47.
  7. Duan, W., et al., Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice. Proc Natl Acad Sci U S A, 2003; 100(5): 2911-6.
  8. Yu, Z.F. and M.P. Mattson, Dietary restriction and 2-deoxyglucose administration reduce focal ischemic brain damage and improve behavioral outcome: evidence for a preconditioning mechanism. J Neurosci Res, 1999; 57(6): 830-9.
  9. Sabatino, F., et al., Assessment of the role of the glucocorticoid system in aging processes and in the action of food restriction. J Gerontol, 1991; 46(5): B171-9.
  10. Zhu, M., et al., Adipogenic signaling in rat white adipose tissue: modulation by aging and calorie restriction. Exp Gerontol, 2007; 42(8): 733-44.
  11. Andrews, Z.B., The extra-hypothalamic actions of ghrelin on neuronal function. Trends Neurosci, 2011; 34(1): 31-40.
  12. Masoro, E.J., The role of hormesis in life extension by dietary restriction. Interdiscip Top Gerontol, 2007; 35: 1-17.
  13. Masoro, E.J., Hormesis and the antiaging action of dietary restriction. Exp Gerontol, 1998; 33(1-2): 61-6.
  14. Qin, W., et al., Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer diseaseamyloid neuropathology by calorie restriction. J Biol Chem, 2006; 281(31): 21745-54.
  15. Froy, O. and R. Miskin, Effect of feeding regimens on circadian rhythms: implications for aging and longevity. Aging (Albany NY), 2010; 2(1): 7-27.
  16. Froy, O., The relationship between nutrition and circadian rhythms in mammals. Front Neuroendocrinol, 2007; 28(2-3): 61-71.
  17. Zawilska, J.B., et al., Daily oscillation in melatonin synthesis in the Turkey pineal gland and retina: diurnal and circadian rhythms. Chronobiol Int, 2006; 23(1-2): 341-50.
  18. Feillet, C.A., Food for thoughts: feeding time and hormonal secretion. J Neuroendocrinol, 2010; 22(6): 620-8.
  19. Ni, C., et al., Melatonin premedication attenuates isoflurane anesthesia-induced beta-amyloid generation and cholinergic dysfunction in the hippocampus of aged rats. Int J Neurosci, 2013; 123(4): 213-20.
  20. Liu, X.J., et al., Melatonin protects against amyloid-beta-induced impairments of hippocampal LTP and spatial learning in rats. Synapse, 2013; 67(9): 626-36.
  21. Shen, Y.X., et al., Improvement of melatonin to the learning and memory impairment induced by amyloid beta-peptide 25 - 35 in elder rats. Acta Pharmacol Sin, 2001; 22(9): 797-803.
  22. Saxena, G., et al., Melatonin alleviates memory deficits and neuronal degeneration induced by intracerebroventricular administration of streptozotocin in rats. Pharmacol Biochem Behav, 2010; 94(3): 397-403.
  23. Argyriou, A., H. Prast, and A. Philippu, Melatonin facilitates short-term memory. Eur J Pharmacol, 1998; 349(2-3): 159-62.
  24. Wu, Y.H. and D.F. Swaab, The human pineal gland and melatonin in aging and Alzheimer's disease. J Pineal Res, 2005; 38(3): 145-52.
  25. Salkovic-Petrisic, M., et al., Modeling sporadic Alzheimer's disease: the insulin resistant brain state generates multiple long-term morphobiological abnormalities including hyperphosphorylated tau protein and amyloid-beta. J Alzheimers Dis, 2009; 18(4): 729-50.
  26. Browning, C., et al., Pharmacological characterization of human recombinant melatonin mt(1) and MT(2) receptors. Br J Pharmacol, 2000; 129(5): 877-86.
  27. Dubocovich, M.L., et al., Selective MT2 melatonin receptor antagonists block melatonin-mediated phase advances of circadian rhythms. FASEB J, 1998; 12(12): 1211-20.
  28. Tajes, M., et al., Neuroprotective role of intermittent fasting in senescence-accelerated mice P8 (SAMP8). Exp Gerontol, 2010; 4: 702-10.
  29. Jeong, M.A., et al., Intermittent fasting improves functional recovery after rat thoracic contusion spinal cord injury. J Neurotrauma, 2011; 28(3): 479-92.
  30. Plunet, W.T., et al., Dietary restriction started after spinal cord injury improves functional recovery. Exp Neurol, 2008; 213(1): 28-35.
آمار
تعداد مشاهده مقاله: 2,421
تعداد دریافت فایل اصل مقاله: 446


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب