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Faghih, Zeinab, Rezaei, Zahra, Jamshidzadeh, Akram, Faghih, Zahra, Heidari, Naser, Khabnadideh, Soghra. (1396). Cytotoxic evaluation of some new and potent azole derivatives as antimicrobial agents. سامانه مدیریت نشریات علمی, 3(3), 143-148.
Zeinab Faghih; Zahra Rezaei; Akram Jamshidzadeh; Zahra Faghih; Naser Heidari; Soghra Khabnadideh. "Cytotoxic evaluation of some new and potent azole derivatives as antimicrobial agents". سامانه مدیریت نشریات علمی, 3, 3, 1396, 143-148.
Faghih, Zeinab, Rezaei, Zahra, Jamshidzadeh, Akram, Faghih, Zahra, Heidari, Naser, Khabnadideh, Soghra. (1396). 'Cytotoxic evaluation of some new and potent azole derivatives as antimicrobial agents', سامانه مدیریت نشریات علمی, 3(3), pp. 143-148.
Faghih, Zeinab, Rezaei, Zahra, Jamshidzadeh, Akram, Faghih, Zahra, Heidari, Naser, Khabnadideh, Soghra. Cytotoxic evaluation of some new and potent azole derivatives as antimicrobial agents. سامانه مدیریت نشریات علمی, 1396; 3(3): 143-148.

Cytotoxic evaluation of some new and potent azole derivatives as antimicrobial agents

Trends in Pharmaceutical Sciences
مقاله 1، دوره 3، شماره 3، آذر 2017، صفحه 143-148    اصل مقاله (407.62 K)
نوع مقاله: Research(Original) Article
نویسندگان
Zeinab Faghih؛ Zahra Rezaei؛ Akram Jamshidzadeh؛ Zahra Faghih؛ Naser Heidari؛ Soghra Khabnadideh*
چکیده
Recently use of antifungal drugs in human medicine has been increased, especially with the advent of AIDS epidemic. Despite the growing list of azoles, their clinical value has been limited by their relatively high risk of toxicity and the emergence of drug resistance. Efforts have focused on the development of new, less toxic and more efficacious antifungal agents. We previously described synthesis of some new azole derivatives. We also evaluated all the synthesized compounds for their antifungal activity.  Most of our compounds showed desirable activity against different species of microorganisms. Here we choose thirteen of these compounds, 5 bentriazole derivatives (1a-5a), 5 imidazole derivatives (1b-5b) and 3 triazole derivatives (1c-3c) to evaluate their cytotoxic activities against a human cancer cell line (MCF-7) using colorimetric MTT cytotoxic assay. Their cytotoxic activities were compared to clotrimazole as a positive control. Our results collectively showed that most of our synthesized compounds had less cytotoxicity against MCF-7 compared to clotrimazole. 
کلیدواژه‌ها
Azole؛ Antifungal؛ MTT assay؛ MCF-7 cell line
مراجع
  1. Lamb D, Kelly D, Kelly S. Molecular aspects of azole antifungal action and resistance. Drug Resistance Updates. 1999;2(6):390-402.
  2. Calabrese EC, Castellano S, Santoriello M, Sgherri C, Quartacci MF, Calucci L, et al. Antifungal activity of azole compounds CPA18 and CPA109 against azole-susceptible and-resistant strains of Candida albicans. Journal of Antimicrobial Chemotherapy. 2013:dks506.
  3. Lupetti A, Danesi R, Campa M, Del Tacca M, Kelly S. Molecular basis of resistance to azole antifungals. Trends in molecular medicine. 2002;8(2):76-81.
  4. de Araújo Neto LN, do Carmo Alves de Lima M, de Oliveira JF, de Souza ER, Buonafina MDS, Vitor Anjos MN, et al. Synthesis, cytotoxicity and antifungal activity of 5-nitro-thiophene-thiosemicarbazones derivatives. Chemico-Biological Interactions. 2017;272:172-81.
  5. Lo Re V, Carbonari DM, Lewis JD, Forde KA, Goldberg DS, Reddy KR, et al. Oral Azole Antifungal Medications and Risk of Acute Liver Injury, Overall and by Chronic Liver Disease Status. The American Journal of Medicine. 2016;129(3):283-91.e5.
  6. Sun B, Huang W, Liu M. Evaluation of the combination mode of azoles antifungal inhibitors with CACYP51 and the influence of Site-directed mutation. Journal of Molecular Graphics and Modelling. 2017;73:157-65.
  7. Li S, Chen J-X, Xiang Q-X, Zhang L-Q, Zhou C-H, Xie J-Q, et al. The synthesis and activities of novel mononuclear or dinuclear cyclen complexes bearing azole pendants as antibacterial and antifungal agents. European Journal of Medicinal Chemistry. 2014;84:677-86.
  8. Khabnadideh S, Rezaei Z, Khalafi-Nezhad A, Bahrinajafi R, Mohamadi R, Farrokhroz AA. Synthesis of N-Alkylated derivatives of imidazole as antibacterial agents. Bioorganic & Medicinal Chemistry Letters. 2003;13(17):2863-5.
  9. Khabnadideh S, Rezaei Z, Motazedian MH, Eskandari M. Synthesis of metronidazole derivatives as antigiardiasis agents. DARU Journal of Pharmaceutical Sciences. 2007;15(1):17-20.
  10. Khabnadideh S, Rezaei Z, Khalafi-Nezhad A, Pakshir K, Heiran MJ, Shobeiri H. Design and synthesis of 2-methyl and 2-methyl-4-nitro imidazole derivatives as antifungal agents. Iranian Journal of Pharmaceutical Sciences. 2009;5(1):31-6.
  11. Rezaei Z, Khabnadideh S, Pakshir K, Hossaini Z, Amiri F, Assadpour E. Design, synthesis, and antifungal activity of triazole and benzotriazole derivatives. European Journal of Medicinal Chemistry. 2009;44(7):3064-7.
  12. Khabnadideh S, Rezaei Z, Ghasemi Y, Montazeri-Najafabady N. Antibacterial activity of some new azole compounds. Anti-Infective Agents. 2012;10(1):26-33.
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