LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,149
تعداد مقالات10,518
تعداد مشاهده مقاله45,416,125
تعداد دریافت فایل اصل مقاله11,291,843
foroughinia, farzaneh, Hashemian, Seyed Mohammadreza, Fahimi, Fanak. (1395). Drug utilization evaluation of meropenem: an important broad-spectrum antibiotic for the treatment of serious bacterial infections in hospitalized patients. سامانه مدیریت نشریات علمی, 3(1), 25-30.
farzaneh foroughinia; Seyed Mohammadreza Hashemian; Fanak Fahimi. "Drug utilization evaluation of meropenem: an important broad-spectrum antibiotic for the treatment of serious bacterial infections in hospitalized patients". سامانه مدیریت نشریات علمی, 3, 1, 1395, 25-30.
foroughinia, farzaneh, Hashemian, Seyed Mohammadreza, Fahimi, Fanak. (1395). 'Drug utilization evaluation of meropenem: an important broad-spectrum antibiotic for the treatment of serious bacterial infections in hospitalized patients', سامانه مدیریت نشریات علمی, 3(1), pp. 25-30.
foroughinia, farzaneh, Hashemian, Seyed Mohammadreza, Fahimi, Fanak. Drug utilization evaluation of meropenem: an important broad-spectrum antibiotic for the treatment of serious bacterial infections in hospitalized patients. سامانه مدیریت نشریات علمی, 1395; 3(1): 25-30.

Drug utilization evaluation of meropenem: an important broad-spectrum antibiotic for the treatment of serious bacterial infections in hospitalized patients

Trends in Pharmaceutical Sciences
مقاله 5، دوره 3، شماره 1، خرداد 2017، صفحه 25-30    اصل مقاله (322.57 K)
نوع مقاله: Research(Original) Article
نویسندگان
farzaneh foroughinia1؛ Seyed Mohammadreza Hashemian2؛ Fanak Fahimi* 3
1Clinical Pharmacy Department, School of pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
2Nursing and Respiratory Health Management Research Center, NRITLD, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3Clinical Pharmacy Department, School of pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
چکیده
Increasing trend in the development of antibiotic resistance is one the major concerns of health care systems throughout the world. Several factors are responsible of the emergence of this problem of which frequent inappropriate uses of antimicrobial agents plays an important role. Therefore, in the study we aimed to assess the appropriateness of the usage of meropenem, a broad-spectrum antibiotic, in a teaching affiliated hospital.This study is an observational prospective research on drug utilization. All patients admitted to Masih Daneshvari hospital that had received meropenem during Jun to July 2011 were enrolled in the study. To evaluate the appropriate use of meropenem, an institutional standard guideline was designed by pharmacy and therapeutic committee using evidence-based guidelines. Prescriptions were considered appropriate if they were compliant with the guideline.  The total number of meropenem vials used during this period was 2153 vials. Most prescriptions started empirically (85.9%). Of these, 16.9% of prescriptions continued according to lab results whereas 69% of meropenem courses remained empirical. Our results showed that meropenem was started appropriately in 64.8% of patients whereas just 74.3% of patients received the drug for an adequate duration.In conclusion, our study and several other surveys detected various areas of inappropriate use of broad-spectrum antiobiotics such as meropenem. With regard to the important role of these drugs in the treatment of serious nosocomial infections, a combination of both restrictive and educational measures appears to be necessary to improve rational antibiotic usage as well as to decrease in the frequency of antibiotic resistant.
کلیدواژه‌ها
Drug utilization evaluation؛ meropenem؛ antibiotic resistance
مراجع
  1. Marcus EL, Clarfield AM, Moses AE. Ethical issues relating to the use of antimicrobial therapy in older adults. Clin Infect Dis. 2001; 33:1697-705. Epub 2001 Oct 5.
  2. Roark MK, Reed WE Jr. Econotherapeutics. Diagn. Microbiol. Diagn Microbiol Infect Dis. 1995; 22:209-17.
  3. Yinnon AM, Skorohod Y, Schlesinger Y, Greenberg A. Cefuroxime utilization evaluation: impact of physician education on prescribing patterns. Isr Med Assoc J. 2000; 2:187-91.
  4. Gupta LC, Gupta CK, Jain BB, Garg MG. ABC and VED analysis in medical stores inventory control. Med J Armed Forces India. 2007; 63:325-7. doi: 10.1016/S0377-1237(07)80006-2. Epub 2011 Jul 21.
  5. Mohr JF 3rd. Update on the efficacy and tolerability of meropenem in the treatment of serious bacterial infections. Clin Infect Dis. 2008; 47 Suppl 1:S41-51. doi: 10.1086/590065.
  6. McEvoy GK, ed in chief, Snow ED, ed. AHFS: Drug Information. Bethesda, MD: American Society of Health-System Pharmacists; 2008:1125-1126.
  7. Balderson BJ, Yates ME, Patil NP, Suda KJ. Evaluation of doripenem utilization and susceptibilities at a large urban hospital. Int J Clin Pharm. 2011; 33:958-63. doi: 10.1007/s11096-011-9567-1. Epub 2011 Oct 8.
  8. Kollef M, Niederman M. Antimicrobial resistance in the ICU: The time for action is now. Crit Care Med. 2001; 29(4 Suppl):N63.
  9. Mladenovic-Antic S, Kocic B, Velickovic-Radovanovic R, Dinic M, Petrovic J, Randjelovic G, et al. Correlation between antimicrobial consumption and antimicrobial resistance of Pseudomonas aeruginosa in a hospital setting: a 10-year study. J Clin Pharm Ther. 2016; 41:532-7. doi: 10.1111/jcpt.12432. Epub 2016 Aug 11.
  10. Gould IM, Jappy B. Trends in hospital antibiotic prescribing after introduction of an antibiotic policy. J Antimicrob Chemother. 1996 Nov;38(5):895-904.
  11. Tarcea Bizo P, Dumitras D, Popa A. Evaluation of restricted antibiotic use in a hospital in Romania. Int J Clin Pharm. 2015; 37:452-6. doi: 10.1007/s11096-015-0096-1. Epub 2015 Apr 2.
  12. Thuong M, Shortgen F, Zazempa V, Girou E, Soussy CJ, Brun-Buisson C. Appropriate use of restricted antimicrobial agents in hospitals: the importance of empirical therapy and assisted re-evaluation. J Antimicrob Chemother. 2000; 46:501-8.
  13. Raveh D, Muallem-Zilcha E, Greenberg A, Wiener-Well Y, Schlesinger Y, Yinnon AM. Prospective drug utilization evaluation of three broad-spectrum antimicrobials: cefepime, piperacillin-tazobactam and meropenem. QJM. 2006; 99:397-406. Epub 2006 May 8.
  14. Khan MU, Yousuf RI, Shoaib MH. Drug utilization evaluation of meropenem and correlation of side effects with renal status of patients in a teaching based hospital. Pak J Pharm Sci. 2014; 27:1503-8.
  15. Anglim AM, Klym B, Byers K. E, Scheld WM, Farr BM. Effect of a vancomycin restriction policy on ordering practices during an outbreak of vancomycin-resistant Enterococcus faecium. Arch Intern Med. 1997; 157:1132-6.
  16. Goldmann DA, Weinstein RA, Wenzel RP, Tablan OC, Duma RJ, Gaynes RP, et al. Strategies to prevent and control the emergence and spread of antimicrobial-resistant microorganisms in hospitals. A challenge to hospital leadership. JAMA. 1996; 275:234-40.
  17. Lew KY, Ng TM, Tan M, Tan SH, Lew EL, Ling LM, et al. Safety and clinical outcomes of carbapenem de-escalation as part of an antimicrobial stewardship programme in an ESBL-endemic setting. J Antimicrob Chemother. 2015; 70:1219-25. doi: 10.1093/jac/dku479. Epub 2014 Dec 3.
آمار
تعداد مشاهده مقاله: 9,712
تعداد دریافت فایل اصل مقاله: 908


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب