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Firouzabadi, Negar, Hooshangi Shayesteh, Mohammad Reza, Erfani, Nasrollah, Alavi Shoushtari, Ali. (1395). Genetic variation in ACE A2350G: association with reduction in fasting blood glucose after fluoxetine therapy in depressed patients. سامانه مدیریت نشریات علمی, 2(4), 277-284.
Negar Firouzabadi; Mohammad Reza Hooshangi Shayesteh; Nasrollah Erfani; Ali Alavi Shoushtari. "Genetic variation in ACE A2350G: association with reduction in fasting blood glucose after fluoxetine therapy in depressed patients". سامانه مدیریت نشریات علمی, 2, 4, 1395, 277-284.
Firouzabadi, Negar, Hooshangi Shayesteh, Mohammad Reza, Erfani, Nasrollah, Alavi Shoushtari, Ali. (1395). 'Genetic variation in ACE A2350G: association with reduction in fasting blood glucose after fluoxetine therapy in depressed patients', سامانه مدیریت نشریات علمی, 2(4), pp. 277-284.
Firouzabadi, Negar, Hooshangi Shayesteh, Mohammad Reza, Erfani, Nasrollah, Alavi Shoushtari, Ali. Genetic variation in ACE A2350G: association with reduction in fasting blood glucose after fluoxetine therapy in depressed patients. سامانه مدیریت نشریات علمی, 1395; 2(4): 277-284.

Genetic variation in ACE A2350G: association with reduction in fasting blood glucose after fluoxetine therapy in depressed patients

Trends in Pharmaceutical Sciences
مقاله 6، دوره 2، شماره 4، اسفند 2016، صفحه 277-284    اصل مقاله (318.67 K)
نوع مقاله: Research(Original) Article
نویسندگان
Negar Firouzabadi* ؛ Mohammad Reza Hooshangi Shayesteh؛ Nasrollah Erfani؛ Ali Alavi Shoushtari
چکیده
Various studies have shown that genetic factors contribute substantially to the development and progression of diabetes. Renin-angiotensin system has long been proven to have a major role in cardiovascular physiology and pathology. Its major product Angiotensin II (Ang II) with pro oxidant properties has shown to predict the future risk of diabetes. Fluoxetine, a drug of choice in management of depression, was observed to reduce fasting blood sugar (FBS). In the present study, six common polymorphisms of genes encoding for RAS components were determined in DNAs extracted from venous blood of 100newly diagnosed depressed individuals taking 12 weeks of fluoxetine. Blood samples were collected prior and after the period of treatment in order to measure FBS. Our results indicate that carriers of GG genotype of ACE A2350G showed significantly lower FBS levels after fluoxetine treatment (P=0.043). On the other hand haplotype analysis designate a significant association between DTG carriers of ACE I/D, A-240T and A2350G (P=0.001) and reduced FBS levels. In conclusion, this study supports the hypothesis that RAS genetic variations affect blood glucose after a course of treatment in Iranian population with depression
کلیدواژه‌ها
Major depressive disorder؛ Renin-angiotensin system؛ Genetic polymorphisms؛ Fluoxetine؛ Fasting blood sugar
مراجع
  1. Taylor, W., H. Aizenstein, and G. Alexopoulos, The vascular depression hypothesis: mechanisms linking vascular disease with depression. Molecular psychiatry, 2013.
  2. Ferrannini, E., et al., Insulin resistance in essential hypertension. New England Journal of Medicine, 1987. 317(6): p. 350-357.
  3. Zavaroni, I., et al., Prevalence of hyperinsulinaemia in patients with high blood pressure. Journal of internal medicine, 1992. 231(3): p. 235-240.
  4. Kaplan, N., Treating hypertension in the diabetic patient. Clin Diabet, 1987. 5: p. 25-34.
  5. Norhammar, A., et al., Glucose metabolism in patients with acute myocardial infarction and no previous diagnosis of diabetes mellitus: a prospective study. The Lancet, 2002. 359(9324): p. 2140-2144.
  6. Ehlers, M.R.W. and J.F. Riordan, Angiotensin-converting enzyme: new concepts concerning its biological role. Biochemistry, 1989. 28(13): p. 5311-5318.
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