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Jamshidzadeh, Akram, Koohi Hosseinabadi, Omid, Heidari, Reza, Mohammadi Samani, Soliman, Rajabzadeh, Sara, Seyed Raoufi, Seyed Mojtaba, Ahmadi Vadeghani, Alireza. (1394). Wound Healing Activity of a New Formulation from Platelet Lysate. سامانه مدیریت نشریات علمی, 2(1), 35-42.
Akram Jamshidzadeh; Omid Koohi Hosseinabadi; Reza Heidari; Soliman Mohammadi Samani; Sara Rajabzadeh; Seyed Mojtaba Seyed Raoufi; Alireza Ahmadi Vadeghani. "Wound Healing Activity of a New Formulation from Platelet Lysate". سامانه مدیریت نشریات علمی, 2, 1, 1394, 35-42.
Jamshidzadeh, Akram, Koohi Hosseinabadi, Omid, Heidari, Reza, Mohammadi Samani, Soliman, Rajabzadeh, Sara, Seyed Raoufi, Seyed Mojtaba, Ahmadi Vadeghani, Alireza. (1394). 'Wound Healing Activity of a New Formulation from Platelet Lysate', سامانه مدیریت نشریات علمی, 2(1), pp. 35-42.
Jamshidzadeh, Akram, Koohi Hosseinabadi, Omid, Heidari, Reza, Mohammadi Samani, Soliman, Rajabzadeh, Sara, Seyed Raoufi, Seyed Mojtaba, Ahmadi Vadeghani, Alireza. Wound Healing Activity of a New Formulation from Platelet Lysate. سامانه مدیریت نشریات علمی, 1394; 2(1): 35-42.

Wound Healing Activity of a New Formulation from Platelet Lysate

Trends in Pharmaceutical Sciences
مقاله 6، دوره 2، شماره 1، خرداد 2016، صفحه 35-42    اصل مقاله (387.47 K)
نوع مقاله: Research(Original) Article
نویسندگان
Akram Jamshidzadeh1؛ Omid Koohi Hosseinabadi2؛ Reza Heidari3؛ Soliman Mohammadi Samani* 4؛ Sara Rajabzadeh5؛ Seyed Mojtaba Seyed Raoufi6؛ Alireza Ahmadi Vadeghani2
1Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
2Laparoscopy Research Center, Shiraz University of medical Sciences, Shiraz, Iran
3Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
4Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
5International Branch, Shiraz University of Medical Sciences, Shiraz, Iran
6Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Platelet-rich plasma (PRP) is an attractive preparation in regenerative medicine due to its potential role on the healing process in different experimental models. This study was designed to investigate the wound healing activity of a new formulation of PRP. Different gel-based formulations of PRP were prepared. Open excision wounds were made on the back of male Sprague-Dawley rats, and PRP gel was administered topically once daily until the wounds healed completely (12 days). The results revealed that the tested PRP formulation significantly accelerated the wound healing process by increasing the wound contracting, tissue granulization, vascularization, and collagen regeneration. Interestingly, we found that there were no significant differences between PRP formulation and its gel base in all above mentioned parameters. Although this investigation showed that PRP formulation had significant wound healing effects, but the PRP gel base also had significant wound healing properties. This might indicate the wound healing properties of the PRP gel ingredients in the current investigation.
کلیدواژه‌ها
Gel-based new formulation؛ Growth factors؛ Platelet-Rich plasma؛ Regenerative medicine؛ Wound
مراجع
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