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Niknahad, Hossein, Heidari, Reza, Mokhtebaz, Tannaz, Mansouri, Sasan, Dehshahri, Shadab, Abdoli, Narges, Najibi, Asma. (1394). Evaluating the effects of different fractions obtained from Gundelia tournefortii extract against carbon tetrachloride-induced liver injury in rats. سامانه مدیریت نشریات علمی, 2(1), 25-34.
Hossein Niknahad; Reza Heidari; Tannaz Mokhtebaz; Sasan Mansouri; Shadab Dehshahri; Narges Abdoli; Asma Najibi. "Evaluating the effects of different fractions obtained from Gundelia tournefortii extract against carbon tetrachloride-induced liver injury in rats". سامانه مدیریت نشریات علمی, 2, 1, 1394, 25-34.
Niknahad, Hossein, Heidari, Reza, Mokhtebaz, Tannaz, Mansouri, Sasan, Dehshahri, Shadab, Abdoli, Narges, Najibi, Asma. (1394). 'Evaluating the effects of different fractions obtained from Gundelia tournefortii extract against carbon tetrachloride-induced liver injury in rats', سامانه مدیریت نشریات علمی, 2(1), pp. 25-34.
Niknahad, Hossein, Heidari, Reza, Mokhtebaz, Tannaz, Mansouri, Sasan, Dehshahri, Shadab, Abdoli, Narges, Najibi, Asma. Evaluating the effects of different fractions obtained from Gundelia tournefortii extract against carbon tetrachloride-induced liver injury in rats. سامانه مدیریت نشریات علمی, 1394; 2(1): 25-34.

Evaluating the effects of different fractions obtained from Gundelia tournefortii extract against carbon tetrachloride-induced liver injury in rats

Trends in Pharmaceutical Sciences
مقاله 5، دوره 2، شماره 1، خرداد 2016، صفحه 25-34    اصل مقاله (989.29 K)
نوع مقاله: Research(Original) Article
نویسندگان
Hossein Niknahad1؛ Reza Heidari* 2؛ Tannaz Mokhtebaz3؛ Sasan Mansouri3؛ Shadab Dehshahri4؛ Narges Abdoli5؛ Asma Najibi6
1Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. & Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
2Shiraz University of Medical Sciences, Pharmaceutical Sciences Research Center
3Student Research Committee, International branch, Shiraz University of Medical Sciences, Shiraz, Iran
4Department of Pharmacognosy, School of Pharmacy, Shiraz University of Medical Sciences, International Branch, Shiraz, Iran
5Food and Drug Organization, Ministry of Health, Tehran, Iran
6Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Xenobiotics-induced liver injury is a major challenge for clinicians and pharmaceutical industry. Hence, finding new therapeutic molecules against this complication has clinical value. The current investigation aimed to evaluate the potential protective effects of different fractions obtained from Gundelia tournefortii (GT) hydroalcoholic extract in a rat model of acute hepatic injury. Male Sprague-Dawley rats (200‑250 g) were treated with carbon tetrachloride (CCl4) (1.5 ml/kg, i.p), then ethanol, water, chloroform, ethyl acetate, and n-Butanol fractions of GT extract were administered. Biochemical and histopathological markers of hepatic injury were assessed and glutathione (GSH) and lipid peroxidation were monitored in liver samples. CCl4 administration caused hepatotoxicity as revealed by an increase in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) activity, as well as pathological changes of the liver. Furthermore, a significant reduction in hepatic glutathione content and an elevation in lipid peroxidation were observed in CCl4‑treated rats. It was found that the n‑butanol (200 mg/kg) and the ethyl acetate (300 mg/kg) fractions of GT extract protected liver against CCL4‑induced damage as judged by lower AST, ALT, LDH and lipid peroxidation, prevention of tissue glutathione depletion, and alleviation of histopathological damages of liver in extract‑treated animals. As n‑butanol and the ethyl acetate fractions of GT effectively alleviated the liver injury induced by CCl4 and provide antioxidant properties, we might be able to propose that the hepatoprotective chemicals of Gundelia extract are present in these fractions.
کلیدواژه‌ها
Gundelia tournefortii؛ Hepatoprotective؛ Hepatotoxicity؛ Liver injury؛ medicinal plants
مراجع
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