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Erfanfar, Fatemeh, Montaseri, Hashem, Mohagheghzadeh, Abdolali, Hosseinkhani, Ayda. (1394). Myrrh a traditional medicine or a multipurpose pharmaceutical excipient. سامانه مدیریت نشریات علمی, 1(4), 207-212.
Fatemeh Erfanfar; Hashem Montaseri; Abdolali Mohagheghzadeh; Ayda Hosseinkhani. "Myrrh a traditional medicine or a multipurpose pharmaceutical excipient". سامانه مدیریت نشریات علمی, 1, 4, 1394, 207-212.
Erfanfar, Fatemeh, Montaseri, Hashem, Mohagheghzadeh, Abdolali, Hosseinkhani, Ayda. (1394). 'Myrrh a traditional medicine or a multipurpose pharmaceutical excipient', سامانه مدیریت نشریات علمی, 1(4), pp. 207-212.
Erfanfar, Fatemeh, Montaseri, Hashem, Mohagheghzadeh, Abdolali, Hosseinkhani, Ayda. Myrrh a traditional medicine or a multipurpose pharmaceutical excipient. سامانه مدیریت نشریات علمی, 1394; 1(4): 207-212.

Myrrh a traditional medicine or a multipurpose pharmaceutical excipient

Trends in Pharmaceutical Sciences
مقاله 4، دوره 1، شماره 4، اسفند 2015، صفحه 207-212    اصل مقاله (288.94 K)
نوع مقاله: Research(Original) Article
نویسندگان
Fatemeh Erfanfar* 1؛ Hashem Montaseri2؛ Abdolali Mohagheghzadeh3؛ Ayda Hosseinkhani4
11 Department of pharmaceutical quality control, School of pharmacy, Shiraz University of medical sciences, Shiraz, Iran; 2 Research Center for traditional medicine and history of medicine, Shiraz University of medical sciences, Shiraz, Iran;
21 Department of pharmaceutical quality control, School of pharmacy, Shiraz University of medical sciences, Shiraz, Iran; 2 Department of pharmaceutics, School of pharmacy, Shiraz University of medical sciences, Shiraz, Iran;
3Department of phytopharmaceuticals (traditional pharmacy), school of pharmacy, Shiraz University of medical sciences, Shiraz, Iran;
41 Research Centre for traditional medicine and history of medicine, Shiraz University of medical sciences, Shiraz, Iran; 2 Department of pharmaceutical quality control, School of pharmacy, Shiraz University of medical sciences, Shiraz, Iran; 3 Department of phytopharmaceuticals (traditional pharmacy), school of pharmacy, Shiraz University of medical sciences, Shiraz, Iran;
چکیده
Introduction: A drug dosage form contains excipients as well as active pharmaceutical ingredients. Formerly excipients were considered as inert components which were used by a formulator to provide suitable volume, weight and consistency of a dosage form. Today however, excipients are expected to perform multifunctional roles such as enhancing physical, chemical and microbial stability of the dosage form, improving the color or odor of the formulation and influencing the release and bioavailability of the active ingredient. Among various excipients, natural ones seem to be more beneficial to use, since they are economical, safe, biodegradable and biocompatible. In this article, Myrrh oleo- gum- rein is introduced as a potential natural multipurpose excipient that can perform many useful roles in pharmaceutical dosage forms.Materials and methods: Scopus and Google scholar electronic databases were searched to find different properties of myrrh as an excipient. Also ten famous traditional Iranian medicine books were studied to find semisolid formulations named Sabgh which contained myrrh. One of these formulations was prepared and its physical and microbiological stability was assessed. The role of myrrh as an excipient in this formulation was discussed. Results and discussion: Antibacterial and preservative effects shown in the formulation were related to the essential oils of myrrh. The gum portion was found to be a potential surfactant. In addition, myrrh is a natural muco-adhesive and film forming material. These properties were observed for myrrh in the Sabgh formulated in this study as well. So we can conclude that myrrh can be a potential multipurpose excipient in pharmaceutical industries which needs further research.
کلیدواژه‌ها
Commiphora؛ excipient؛ preservative؛ surfactant؛ film forming agent
مراجع
  1. Karolewicz B. A review of polymers as multifunctional excipients in drug dosage form technology. Saudi Pharmaceutical Journal. 2015; doi:10.1016/j.jsps.2015.02.025
  2. Rasala T, Kale V, Lohiya G, Moharir K, Ittadwar A, Awari J. Chemistry and pharmaceutical applications of excipients derived from tamarind. Asian Journal of Chemistry. 2011;23(4):1421-3.
  3. Shirwaikar A, Shirwaikar A, Prabu SL, Kumar GA. Herbal excipients in novel drug delivery systems. Indian journal of pharmaceutical sciences. 2008;70(4):415.
  4. Pudlas M, Kyeremateng SO, Williams LA, Kimber JA, van Lishaut H, Kazarian SG, et al. Analyzing the impact of different excipients on drug release behavior in hot-melt extrusion formulations using FTIR spectroscopic imaging. European Journal of Pharmaceutical Sciences. 2015;67:21-31.
  5. Ogaji IJ. Advances in natural polymers as pharmaceutical excipients. Pharmaceutica Analytica Acta. 2012.
  6. Lemenih M, Abebe T, Olsson M. Gum and resin resources from some Acacia, Boswellia and Commiphora species and their economic contributions in Liban, south-east Ethiopia. Journal of Arid Environments. 2003;55(3):465-82.
  7. CASADEI E, Chikamai B, Singh B. Gums, Resins and Waxes. Industrial Crops and Uses. 2010:411.
  8. Zarshenas MM, Hosseinkhani A, Zargaran A, Kordafshari G, Mohagheghzadeh A. Ophthalmic dosage forms in medieval Persia. Pharm Hist. 2013;43(1):6-8.
  9. Hard to swallow. Nature. 2007;448(7150):105-6.
  10. Kim HU, Ryu JY, Lee JO, Lee SY. A systems approach to traditional oriental medicine. Nat Biotech. 2015;33(3):264-8.
  11. Dolara P, Luceri C, Ghelardini C, Monserrat C, Aiolli S, Luceri F, et al. Analgesic effects of myrrh. Nature. 1996;379(6560):29-.
  12. Etman M, Amin M, Nada AH, Shams-Eldin M, Salama O. Emulsions and rectal formulations containing myrrh essential oil for better patient compliance. Drug discoveries & therapeutics. 2011;5(3):150-6.
  13. Arora G, Malik K, Singh I, Arora S. Formulation and evaluation of controlled release mucoadhesive matrix tablets: Assessment of myrrh oleo gum resin as a natural pharmaceutical excipient. Int J Pharm Sci Drug Res. 2011;3(2):84-8.
  14. El Ashry E, Rashed N, Salama O, Saleh A. Components, therapeutic value and uses of myrrh. Die Pharmazie-An International Journal of Pharmaceutical Sciences. 2003;58(3):163-8.
  15. Walsh ME, Reis D, Jones T. Integrating complementary and alternative medicine: use of myrrh in wound management. Journal of Vascular Nursing. 2010;28(3):102.
  16. Shen T, Li G-H, Wang X-N, Lou H-X. The genus Commiphora: a review of its traditional uses, phytochemistry and pharmacology. Journal of ethnopharmacology. 2012;142(2):319-30.
  17. Xu J, Guo Y, Zhao P, Xie C, Jin D-q, Hou W, et al. Neuroprotective cadinane sesquiterpenes from the resinous exudates of Commiphora myrrha. Fitoterapia. 2011;82(8):1198-201.
  18. Aghili S. Qarabadin Kabir: Iran University of Medical Sciences; 2007. 1086 p.
  19. Heravi MG. Gharabadin Salehi: Iran University of Medical Sciences; 1766. 187 p.
  20. Su S, Wang T, Duan J-A, Zhou W, Hua Y-Q, Tang Y-P, et al. Anti-inflammatory and analgesic activity of different extracts of Commiphora myrrha. Journal of ethnopharmacology. 2011;134(2):251-8.
  21. Lemenith M, Teketay D. Frankincense and myrrh resources of Ethiopia: II. Medicinal and industrial uses. SINET: Ethiopian Journal of Science. 2005;26(2):161-72.
  22. Su S, Hua Y, Wang Y, Gu W, Zhou W, Duan J-a, et al. Evaluation of the anti-inflammatory and analgesic properties of individual and combined extracts from Commiphora myrrha, and Boswellia carterii. Journal of ethnopharmacology. 2012;139(2):649-56.
  23. Abdul-Ghani RA, Loutfy N, Hassan A. Myrrh and trematodoses in Egypt: an overview of safety, efficacy and effectiveness profiles. Parasitology international. 2009;58(3):210-4.
  24. Alves J, Mantovani A, Martins M, Abrao F, Lucarini R, Crotti A, et al. Antimycobacterial Activity of Some Commercially Available Plant-Derived Essential Oils. Chemistry of Natural Compounds. 2015;51(2):353-5.
  25. De Rapper S, Van Vuuren S, Kamatou G, Viljoen A, Dagne E. The additive and synergistic antimicrobial effects of select frankincense and myrrh oils–a combination from the pharaonic pharmacopoeia. Letters in applied microbiology. 2012;54(4):352-8.
  26. Abdel-Maksoud G, El-Amin A-R. A review on the materials used during the mummification processes in ancient Egypt. Mediterranean Archaeology and Archaeometry. 2011;11(2):129-50.
  27. Prakash B, Singh P, Kedia A, Dubey N. Assessment of some essential oils as food preservatives based on antifungal, antiaflatoxin, antioxidant activities and in vivo efficacy in food system. Food Research International. 2012;49(1):201-8.
  28. Dolara P, Corte B, Ghelardini C, Pugliese AM, Cerbai E, Menichetti S, et al. Local anaesthetic, antibacterial and antifungal properties of sesquiterpenes from myrrh. Planta medica. 2000;66(4):356-8.
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