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Mohammadi Samani, Soliman, Jamshidzade, Akram, Seyed Raoufi, Seyed Modjtaba, Mardani, Zeinab. (1394). Topical gel formulation and stability assessment of platelet lysate based on turbidimetric method. سامانه مدیریت نشریات علمی, 1(2), 75-82.
Soliman Mohammadi Samani; Akram Jamshidzade; Seyed Modjtaba Seyed Raoufi; Zeinab Mardani. "Topical gel formulation and stability assessment of platelet lysate based on turbidimetric method". سامانه مدیریت نشریات علمی, 1, 2, 1394, 75-82.
Mohammadi Samani, Soliman, Jamshidzade, Akram, Seyed Raoufi, Seyed Modjtaba, Mardani, Zeinab. (1394). 'Topical gel formulation and stability assessment of platelet lysate based on turbidimetric method', سامانه مدیریت نشریات علمی, 1(2), pp. 75-82.
Mohammadi Samani, Soliman, Jamshidzade, Akram, Seyed Raoufi, Seyed Modjtaba, Mardani, Zeinab. Topical gel formulation and stability assessment of platelet lysate based on turbidimetric method. سامانه مدیریت نشریات علمی, 1394; 1(2): 75-82.

Topical gel formulation and stability assessment of platelet lysate based on turbidimetric method

Trends in Pharmaceutical Sciences
مقاله 3، دوره 1، شماره 2، شهریور 2015، صفحه 75-82    اصل مقاله (392.01 K)
نوع مقاله: Research(Original) Article
نویسندگان
Soliman Mohammadi Samani* 1؛ Akram Jamshidzade2؛ Seyed Modjtaba Seyed Raoufi3؛ Zeinab Mardani3
1Center for Drug Delivery in Nanotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
2Pharmaceutical Sciences Research Center, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
3School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Platelet-rich growth factors have attracted attentions of scientists and clinical practitioners who are involved in wound healing and regenerative medicine extensively, according to their unprecedented potential of promoting and catalyzing healing process. Platelet-rich growth factors are cost-benefit, available and are more stable than recombinant human growth factors. These appealing characteristics have converted PRGF to one of the popular candidate for treatment of variety of wounds. According to these valuable properties, we decided to formulate and assess the effect of different excipients on the stability of such valuable protein based formulations. Different excipients have been chosen according to their effectiveness on the stability of proteins and their application in the other similar formulations. The stabilizing effect of excipients was evaluated by measuring heat-induced aggregation of growth factors by turbidimetric assay. Glycerol, glycine and dextrose were chosen as stabilizing excipient for these formulations. The results show that dextrose has more stabilizing effect on prevention of heat induced aggregation of the platelet lysate growth factors than glycerol and glycine. All of the formulations also contained antioxidant, chelating agents, preservative and carbopol 934 in order to form appropriate gel
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