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Sadeghpour, Hossein, Alavi, Mehrosadat, Shahedi, Majid, Entezarmahdi, Seyed Mohammad, Sakhteman, Amirhossein. (1393). Evaluation of radiochemical purities of some radiopharmaceuticals in Shiraz Namazi teaching hospital. سامانه مدیریت نشریات علمی, 1(1), 15-19.
Hossein Sadeghpour; Mehrosadat Alavi; Majid Shahedi; Seyed Mohammad Entezarmahdi; Amirhossein Sakhteman. "Evaluation of radiochemical purities of some radiopharmaceuticals in Shiraz Namazi teaching hospital". سامانه مدیریت نشریات علمی, 1, 1, 1393, 15-19.
Sadeghpour, Hossein, Alavi, Mehrosadat, Shahedi, Majid, Entezarmahdi, Seyed Mohammad, Sakhteman, Amirhossein. (1393). 'Evaluation of radiochemical purities of some radiopharmaceuticals in Shiraz Namazi teaching hospital', سامانه مدیریت نشریات علمی, 1(1), pp. 15-19.
Sadeghpour, Hossein, Alavi, Mehrosadat, Shahedi, Majid, Entezarmahdi, Seyed Mohammad, Sakhteman, Amirhossein. Evaluation of radiochemical purities of some radiopharmaceuticals in Shiraz Namazi teaching hospital. سامانه مدیریت نشریات علمی, 1393; 1(1): 15-19.

Evaluation of radiochemical purities of some radiopharmaceuticals in Shiraz Namazi teaching hospital

Trends in Pharmaceutical Sciences
مقاله 3، دوره 1، شماره 1، خرداد 2015، صفحه 15-19    اصل مقاله (668.89 K)
نوع مقاله: Research(Original) Article
نویسندگان
Hossein Sadeghpour* 1؛ Mehrosadat Alavi2؛ Majid Shahedi3؛ Seyed Mohammad Entezarmahdi4؛ Amirhossein Sakhteman5
11- Department of medicinal chemistry, faculty of pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran 2- Nuclear Medicine and Molecular Imaging Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran.
2Department of nuclear medicine, Namazi hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
3Department of medicinal chemistry, faculty of pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
41-Nuclear Medicine and Molecular Imaging Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. 2- Medical Radiation Engineering Department, Shahid Beheshti University, Tehran, Iran.
5Department of medicinal chemistry, faculty of pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
چکیده
Radiopharmaceuticals are a special group of drugs since many of them are eventually prepared in the hospital and the nuclear medicine department is therfore responsible for meeting quality criteria such as sterility, radionuclide, radiochemical and chemical purity. In this study radiochemical purity for more than 300 preparations of three different radiopharmaceutical formulations from commercial kits were tested using instant thin layer chromatography. The formulations namely 99mTc-DTPA, 99mTc-MDP and 99mTc-MIBI were obtained from Pars Isotope Co. Several paper chromatographic systems were used in this study. The result showed that the most observed impurities were hydrolyzed reduced 99m technetium.  After the preliminary study we decided to change our imaging schedule in the nuclear medicine department and the sequence of imaging was changed.Cosequently, the results showed better radiochemical purities. Our equipments for detetion of radioactivity in paper chromatography were changed, for example the old dose calibrator was replaced by a gamma camera or a more accurate dose calibrator. Also, the thin layer chromatography systems  were changed to those recommended by the factory  and the new results showed much better radiochemical purities.
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