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Maji, Suvendu, Ghosh, Indranil. (1397). Recurrent Neuroglycopenia: Do Not Forget Non-islet Cell Induced Tumor Hypoglycemia. سامانه مدیریت نشریات علمی, 9(4), 344-347. doi: 10.30476/mejc.2018.42140
Suvendu Maji; Indranil Ghosh. "Recurrent Neuroglycopenia: Do Not Forget Non-islet Cell Induced Tumor Hypoglycemia". سامانه مدیریت نشریات علمی, 9, 4, 1397, 344-347. doi: 10.30476/mejc.2018.42140
Maji, Suvendu, Ghosh, Indranil. (1397). 'Recurrent Neuroglycopenia: Do Not Forget Non-islet Cell Induced Tumor Hypoglycemia', سامانه مدیریت نشریات علمی, 9(4), pp. 344-347. doi: 10.30476/mejc.2018.42140
Maji, Suvendu, Ghosh, Indranil. Recurrent Neuroglycopenia: Do Not Forget Non-islet Cell Induced Tumor Hypoglycemia. سامانه مدیریت نشریات علمی, 1397; 9(4): 344-347. doi: 10.30476/mejc.2018.42140

Recurrent Neuroglycopenia: Do Not Forget Non-islet Cell Induced Tumor Hypoglycemia

Middle East Journal of Cancer
مقاله 13، دوره 9، شماره 4، دی 2018، صفحه 344-347    اصل مقاله (2.94 M)
نوع مقاله: Case Report(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2018.42140
نویسندگان
Suvendu Maji* ؛ Indranil Ghosh
Department of Surgical Oncology, Chittaranjan National Cancer Institute, West Bengal, India
چکیده
Non-islet cell tumor hypoglycemia (NICTH) is an exceedingly rare paraneoplastic condition and often its commonest presenting symptom is hypoglycaemia. Most cases of NICTH are associated with underlying mesenchymal or epithelial neoplasm. However our case is unique as NICTH was associated with well differentiated liposarcoma, which has never been described before. Most of the reported cases of NICTH were diagnosed on the basis of biochemical tests. However NICTH can also be a diagnosis of exclusion as highlighted by our case report. This case also highlights both the diagnostic dilemma and the surgical challenges in the management of such cases. The elderly lady presented with repeated episodes of loss of unconsciousness for which she was hospitalised twice. Her symptoms closely resembled that of a cerebrovascular accident patient. However CT brain did not reveal any brain lesion. However she also had spontaneous episodes of hypoglycaemia which led to further investigations. Ultrasonography abdomen revealed presence of huge retroperitoneal mass on FNAB which was malignant. Subsequently, she was put on dextrose drip and thorough investigations ruled out metastatic disease. She underwent laparotomy and the mass was excised enbloc. Postoperative recovery was smooth and the hypoglycaemia resoled spontaneously. Final histopathologic examination was suggestive of well differentiated liposarcoma. At the 6-month follow-up, she was free from hypoglycemic episodes. This case highlights that NICTH can be a difficult diagnosis given its propensity to mimic several other benign conditions. NICTH can also be caused by liposarcomas. Diagnosis by excluding all other causes of hypoglycaemia is also an option where costly biochemical tests are unavailable. Surgical excision is the main stay of treatment.
کلیدواژه‌ها
NICTH؛ Liposarcoma؛ Atypical lipomatous tumour؛ Paraneoplastic syndrome؛ Hypoglycemia
مراجع
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