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Intratumoral Heterogeneity in Breast Cancer: A Case Report and Molecular Discussion | ||
| Middle East Journal of Cancer | ||
| مقاله 12، دوره 9، شماره 4، دی 2018، صفحه 339-343 اصل مقاله (2.38 M) | ||
| نوع مقاله: Case Report(s) | ||
| شناسه دیجیتال (DOI): 10.30476/mejc.2018.42138 | ||
| نویسندگان | ||
| Akbar Safaei؛ Ahmad Monabati؛ Maral Mokhtari؛ Mehdi Montazer* | ||
| Department of Hematopathology, Molecular Pathology and Cytogenetics, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| چکیده | ||
| The emerging era of personalized medicine makes it increasingly important to consider intratumoral heterogeneity, which has been found in some breast cancer cases. However, its identification criteria, form of reporting, and subsequent effects on the clinical course of this disease remain controversial and not fully defined. Here, we report and discuss a case of breast invasive ductal adenocarcinoma with substantial intratumoral heterogeneity, discrepancy between Her2/neu immunostaining and in situ hybridization, and disparity between estrogen receptor status before and after neoadjuvant therapy. | ||
| کلیدواژه‌ها | ||
| Breast؛ Estrogen receptor؛ ErbB-2؛ Genetic heterogeneity؛ Personalized medicine | ||
| مراجع | ||
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