LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,149
تعداد مقالات10,518
تعداد مشاهده مقاله45,416,316
تعداد دریافت فایل اصل مقاله11,292,242
Hamed, Rasha, Sakr, Hanem, Lotfy, Ahmed. (1397). Prognostic Factors of Anaplastic Thyroid Carcinoma: An Egyptian Single Institution Experience. سامانه مدیریت نشریات علمی, 9(4), 282-287. doi: 10.30476/mejc.2018.42137
Rasha Hamdy Hamed; Hanem Sakr; Ahmed Lotfy. "Prognostic Factors of Anaplastic Thyroid Carcinoma: An Egyptian Single Institution Experience". سامانه مدیریت نشریات علمی, 9, 4, 1397, 282-287. doi: 10.30476/mejc.2018.42137
Hamed, Rasha, Sakr, Hanem, Lotfy, Ahmed. (1397). 'Prognostic Factors of Anaplastic Thyroid Carcinoma: An Egyptian Single Institution Experience', سامانه مدیریت نشریات علمی, 9(4), pp. 282-287. doi: 10.30476/mejc.2018.42137
Hamed, Rasha, Sakr, Hanem, Lotfy, Ahmed. Prognostic Factors of Anaplastic Thyroid Carcinoma: An Egyptian Single Institution Experience. سامانه مدیریت نشریات علمی, 1397; 9(4): 282-287. doi: 10.30476/mejc.2018.42137

Prognostic Factors of Anaplastic Thyroid Carcinoma: An Egyptian Single Institution Experience

Middle East Journal of Cancer
مقاله 3، دوره 9، شماره 4، دی 2018، صفحه 282-287    اصل مقاله (203.96 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2018.42137
نویسندگان
Rasha Hamdy Hamed* 1؛ Hanem Sakr1؛ Ahmed Lotfy2
1Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt
2General Surgery Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt
چکیده
Background: Anaplastic thyroid carcinoma is an extremely aggressive cancer that has a very poor outcome. We have analyzed predictive factors for overall survival and different therapeutic modalities that could help to determine the optimal therapy for this carcinoma.Methods: We performed a retrospective analysis of data from 54 cases of anaplastic thyroid carcinoma to evaluate demographic, pathological, and clinical characteristics, along with therapeutic modalities that affected survival. The Kaplan-Meier curve was used to visualize the cumulative probability of survival and comparison among/between groups was performed with the log-rank test. A multivariate Cox proportional hazards model was used to examine overall survival.Results: We observed overall survival percentages of 50% (one-year), 25% (2- year), and 5.6% (5-year). The 2-year overall survival was 41.7% for stage IVA, 31.5% for stage IVB, and 7.4% for stage IVC (P= 0.04). The 2-year overall survival rates were 59.3% for patients with negative margins, 30.1% for those with positive margins, and 0.0% in the group without thyroidectomy (P=0.005). Surgery plus postoperative radiotherapy indicated better 2-year overall survival (56%) compared to surgery alone (34.7%, Pone month, no reported metastasis at presentation, negative surgical margins, surgery, radiotherapy, and/or chemotherapy.Conclusion: Anaplastic thyroid carcinoma is an aggressive cancer with a very poor prognosis. Multimodality treatment may improve overall survival in these patients. Duration of symptoms, primary tumor size, distant metastases, surgical treatment, surgical margin status, radiotherapy, and chemotherapy are independent factors that affect prognosis.
مراجع
1. Are C, Shaha AR. Anaplastic thyroid carcinoma: biology, pathogenesis, prognostic factors, and treatment approaches. Ann Surg Oncol. 2006;13(4):453-64

2. Smallridge RC, Copland JA. Anaplastic thyroid carcinoma: pathogenesis and emerging therapies. Clin Oncol (R Coll Radiol). 2010;22(6):486-97.

3. Ranganath R, Shah MA, Shah AR. Anaplastic thyroid cancer. Curr Opin Endocrinol Diabetes Obes. 2015;22(5):387-91.

4. Chen J, Tward JD, Shrieve DC, Hitchcock YJ. Surgery and radiotherapy improves survival in patients with anaplastic thyroid carcinoma: analysis of the surveillance, epidemiology, and end results 1983-2002. Am J Clin Oncol. 2008;31(5):460-4.

5. Kim TY, Kim KW, Jung TS, Kim JM, Kim SW, Chung KW, et al. Prognostic factors for Korean patients with anaplastic thyroid carcinoma. Head Neck. 2007;29(8):765-72.

6. Sugitani I, Miyauchi A, Sugino K, Okamoto T, Yoshida A, Suzuki S. Prognostic factors and treatment outcomes for anaplastic thyroid carcinoma: ATC Research Consortium of Japan cohort study of 677 patients. World J Surg. 2012;36(6):1247-54.

7. Mohebati A, Dilorenzo M, Palmer F, Patel SG, Pfister D, Lee N, et al. Anaplastic thyroid carcinoma: a 25-year single-institution experience. Ann Surg Oncol. 2014;21(5):1665-70.

8. Tennvall J, Lundell G, Wahlberg P, Bergenfelz A, Grimelius L, Akerman M, et al. Anaplastic thyroid carcinoma: three protocols combining doxorubicin, hyperfractionated radiotherapy and surgery. Br J Cancer. 2002;86(12):1848-53.

9. Haigh PI. Anaplastic thyroid carcinoma. Curr Treat Options Oncol. 2000;1(4):353-7.

10. Ain KB, Egorin MJ, DeSimone PA. Treatment of anaplastic thyroid carcinoma with paclitaxel: phase 2 trial using ninety-six-hour infusion. Collaborative Anaplastic Thyroid Cancer Health Intervention Trials (CATCHIT) Group. Thyroid. 2000;10(7):587-94.

11. Akaishi J, Sugino K, Kitagawa W, Nagahama M, Kameyama K, Shimizu K, et al. Prognostic factors and treatment outcomes of 100 cases of anaplastic thyroid carcinoma. Thyroid. 2011;21(11):1183-9.

12. Ruhstaller T, Roe H, Thürlimann B, Nicoll JJ. The multidisciplinary meeting: An indispensable aid to communication between different specialities. Eur J Cancer. 2006;42(15):2459-62.  

13. Kebebew E, Greenspan FS, Clark OH, Woeber KA, McMillan A. Anaplastic thyroid carcinoma. Treatment outcome and prognostic factors. Cancer. 2005;103(7):1330-5.

14. Stavas MJ, Shinohara ET, Attia A, Ning MS, Friedman JM, Cmelak AJ. Short course high dose radiotherapy in the treatment of anaplastic thyroid carcinoma. J Thyroid Res. 2014;2014:764281.

15. Liu TR, Xiao ZW, Xu HN, Long Z, Wei FQ, Zhuang SM, et al. Treatment and prognosis of anaplastic thyroid carcinoma: A clinical study of 50 cases. PLoS One. 2016;11(10):e0164840.

16. Polistena A, Monacelli M, Lucchini R, Triola R, Conti C, Avenia S, et al. The role of surgery in the treatment of thyroid anaplastic carcinoma in the elderly. Int J Surg. 2014;12 Suppl 2:S170-S176.

17. Lee DY, Won JK, Lee SH, Park DJ, Jung KC, Sung MW, et al. Changes of clinicopathologic characteristics and survival outcomes of anaplastic and poorly differentiated thyroid carcinoma. Thyroid. 2016;26(3):404-13.

18.Sugitani I, Miyauchi A, Sugino K, Okamoto T, Yoshida A, Suzuki S. Prognostic factors and treatment outcomes for anaplastic thyroid carcinoma: ATC Research Consortium of Japan cohort study of 677 patients. World J Surg. 2012;36(6):1247-54.

19. Yau T, Lo CY, Epstein RJ, Lam AK, Wan KY, Lang BH. Treatment outcomes in anaplastic thyroid carcinoma: survival improvement in young patients with localized disease treated by combination of surgery and radiotherapy. Ann Surg Oncol. 2008;15(9):2500-5.

20. Glaser SM, Mandish SF, Gill BS, Balasubramani GK, Clump DA, Beriwal S. Anaplastic thyroid cancer: Prognostic factors, patterns of care, and overall survival. Head Neck. 2016;38 Suppl 1:E2083-90.

21. Smallridge RC. Approach to the patient with anaplastic thyroid carcinoma. J Clin Endocrinol Metab. 2012;97(8):2566-72.

22. Pushkarev VM, Starenki DV, Saenko VA, Pushkarev VV, Kovzun OI, Tronko MD, et al. Differential effects of low and high doses of Taxol in anaplastic thyroid cancer cells: possible implication of the Pin1 prolyl isomerase. Exp Oncol. 2008;30(3):190-4.

23. Sun C, Li Q, Hu Z, He J, Li C, Li G, et al. Treatment and prognosis of anaplastic thyroid carcinoma: experience from a single institution in China. PLoS One. 2013;8(11):e80011.

آمار
تعداد مشاهده مقاله: 3,373
تعداد دریافت فایل اصل مقاله: 1,277


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب