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Jalaeikhoo, Hasan, Sharifzadeh, Morteza, Rajaeinejad, Mohsen, Keyhani, Manoutchehr, Zokaasadi, Mohammad. (1397). A Precisely Calculated Neutrophil to Lymphocyte Ratio could Predict Overall Survival in Multiple Myeloma Patients. سامانه مدیریت نشریات علمی, 9(3), 223-227. doi: 10.30476/mejc.2018.42127
Hasan Jalaeikhoo; Morteza Sharifzadeh; Mohsen Rajaeinejad; Manoutchehr Keyhani; Mohammad Zokaasadi. "A Precisely Calculated Neutrophil to Lymphocyte Ratio could Predict Overall Survival in Multiple Myeloma Patients". سامانه مدیریت نشریات علمی, 9, 3, 1397, 223-227. doi: 10.30476/mejc.2018.42127
Jalaeikhoo, Hasan, Sharifzadeh, Morteza, Rajaeinejad, Mohsen, Keyhani, Manoutchehr, Zokaasadi, Mohammad. (1397). 'A Precisely Calculated Neutrophil to Lymphocyte Ratio could Predict Overall Survival in Multiple Myeloma Patients', سامانه مدیریت نشریات علمی, 9(3), pp. 223-227. doi: 10.30476/mejc.2018.42127
Jalaeikhoo, Hasan, Sharifzadeh, Morteza, Rajaeinejad, Mohsen, Keyhani, Manoutchehr, Zokaasadi, Mohammad. A Precisely Calculated Neutrophil to Lymphocyte Ratio could Predict Overall Survival in Multiple Myeloma Patients. سامانه مدیریت نشریات علمی, 1397; 9(3): 223-227. doi: 10.30476/mejc.2018.42127

A Precisely Calculated Neutrophil to Lymphocyte Ratio could Predict Overall Survival in Multiple Myeloma Patients

Middle East Journal of Cancer
مقاله 8، دوره 9، شماره 3، مهر 2018، صفحه 223-227    اصل مقاله (115.88 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2018.42127
نویسندگان
Hasan Jalaeikhoo1؛ Morteza Sharifzadeh1؛ Mohsen Rajaeinejad1؛ Manoutchehr Keyhani2؛ Mohammad Zokaasadi* 1
1AJA Cancer Epidemiology Research and Treatment Center (AJA- CERTC), AJA University of Medical Sciences, Tehran, Iran
2Hematology and Oncology Research Center, Vali Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Background: Neutrophil to lymphocyte ratio was initially used as a low cost prognostic marker in a group of solid tumors and subsequently hypothesized to have a role in multiple myeloma. This retrospective analysis aimed to report the prognostic importance of the neutrophil to lymphocyte ratio in multiple myeloma.Methods: Between November 2003 and February 2016, we included 175 patients from two centers in this study. CBC differentials were primarily checked by a Sysmex analyzer in both centers. In one center, differentials were rechecked by light microscopy. Analysis of survival was performed using a Kaplan-Meier estimate and we assessed the effects of prognostic factors by Cox proportional hazards model.Results: Patients had a mean age of 63.22±10.89 years. Although mean lymphocyte percent did not differ between the two centers, mean neutrophil percent and mean neutrophil to lymphocyte ratio were higher at the center that manually checked the CBC differentials. After adjustments for age and gender, we noted that the hazard ratio for elevated neutrophil to lymphocyte ratio when stratified for the centers was 1.07 (95% CI: 1.01–1.15, P=0.034).Conclusion: A precisely checked neutrophil to lymphocyte ratio could act as a potentially inexpensive, accessible prognostic factor for multiple myeloma patients.
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