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Fathi, Mojtaba, Goodarzvand, Omid, Aghjany-Nasab, Monireh, Mansour-Ghanaei, Fariborz, Nazarian, Aboalfazl. (1397). Correlation between Certain Klotho Gene Polymorphisms and IGF-1 Levels of Colorectal Cancer Patients in Northern Iran. سامانه مدیریت نشریات علمی, 9(2), 151-157. doi: 10.30476/mejc.2018.42117
Mojtaba Fathi; Omid Goodarzvand; Monireh Aghjany-Nasab; Fariborz Mansour-Ghanaei; Aboalfazl Nazarian. "Correlation between Certain Klotho Gene Polymorphisms and IGF-1 Levels of Colorectal Cancer Patients in Northern Iran". سامانه مدیریت نشریات علمی, 9, 2, 1397, 151-157. doi: 10.30476/mejc.2018.42117
Fathi, Mojtaba, Goodarzvand, Omid, Aghjany-Nasab, Monireh, Mansour-Ghanaei, Fariborz, Nazarian, Aboalfazl. (1397). 'Correlation between Certain Klotho Gene Polymorphisms and IGF-1 Levels of Colorectal Cancer Patients in Northern Iran', سامانه مدیریت نشریات علمی, 9(2), pp. 151-157. doi: 10.30476/mejc.2018.42117
Fathi, Mojtaba, Goodarzvand, Omid, Aghjany-Nasab, Monireh, Mansour-Ghanaei, Fariborz, Nazarian, Aboalfazl. Correlation between Certain Klotho Gene Polymorphisms and IGF-1 Levels of Colorectal Cancer Patients in Northern Iran. سامانه مدیریت نشریات علمی, 1397; 9(2): 151-157. doi: 10.30476/mejc.2018.42117

Correlation between Certain Klotho Gene Polymorphisms and IGF-1 Levels of Colorectal Cancer Patients in Northern Iran

Middle East Journal of Cancer
مقاله 10، دوره 9، شماره 2، تیر 2018، صفحه 151-157    اصل مقاله (984.51 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2018.42117
نویسندگان
Mojtaba Fathi1؛ Omid Goodarzvand1؛ Monireh Aghjany-Nasab2؛ Fariborz Mansour-Ghanaei3؛ Aboalfazl Nazarian* 1
1Clinical Biochemistry Department, Zanjan University of Medical Sciences, Zanjan, Iran
2Cellular and Molecular Research Center, Department of Biochemistry-Biophysics, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
3Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences, Rasht, Iran
چکیده
Background: Colorectal cancer susceptibility may correlate with the Klotho gene G-395A and C1818T polymorphisms. This study aims to evaluate the relationship between a Klotho single nucleotide polymorphism and IGF-1 with risk of colorectal cancer.Methods: This study enrolled 60 colorectal cancer patients and 60 age-matched healthy persons who referred to Razi Hospital, Rasht, and Northern Iran in September 2013. Patients enrolled under supervision of a gastro-intestinal specialist and according to the ethics right. G-395A and C1818T polymorphisms were genotyped with polymerase chain confronting two pair primer technology. IGF-1 and certain biochemistry analytes were assayed. Statistical analysis was used to compare appropriate relationships.Results: There were different base pair partitions for G395A and C1818T. Odds ratio and 95% confidence interval were used to analyze the correlation of genotypes and haplotypes with colorectal cancer susceptibility. The AA (odds ratio: 1.437, 95% confidence interval: 0.596) and GA (odds ratio: 1.958, 95% confidence interval: 1.133- 3.385) genotypes of the G-395A polymorphisms showed a slight relationship to the risk of colorectal cancer. The A allele had a much higher frequency in the case group (31.2%) compared with the control group (17.6%). There was no significant relationship with the C1818T polymorphism between the case and control groups.Conclusion: The Klotho gene polymorphism did not significantly increase the risk of colorectal cancer. Therefore, these genotypes might not have a correlation with IGF-1.
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