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Jayachander, Dipika, Shivashankara, Arnadi, Vidyasagar, Mamidipudi, Tonse, Raees, Pais, Sarita, Lobo, Ashwin, Hegde, Sanath, Rao, Suresh, Baliga, Manjeshwar. (1397). Salivary Parameters as Predictive Markers for Radiation-induced Treatment Response in Head and Neck Cancers: An Investigational Study. سامانه مدیریت نشریات علمی, 9(2), 133-142. doi: 10.30476/mejc.2018.42115
Dipika Jayachander; Arnadi Ramachandrayya Shivashankara; Mamidipudi Srinivasa Vidyasagar; Raees Tonse; Sarita Pais; Ashwin DL Lobo; Sanath Kumar Hegde; Suresh Rao; Manjeshwar Shrinath Baliga. "Salivary Parameters as Predictive Markers for Radiation-induced Treatment Response in Head and Neck Cancers: An Investigational Study". سامانه مدیریت نشریات علمی, 9, 2, 1397, 133-142. doi: 10.30476/mejc.2018.42115
Jayachander, Dipika, Shivashankara, Arnadi, Vidyasagar, Mamidipudi, Tonse, Raees, Pais, Sarita, Lobo, Ashwin, Hegde, Sanath, Rao, Suresh, Baliga, Manjeshwar. (1397). 'Salivary Parameters as Predictive Markers for Radiation-induced Treatment Response in Head and Neck Cancers: An Investigational Study', سامانه مدیریت نشریات علمی, 9(2), pp. 133-142. doi: 10.30476/mejc.2018.42115
Jayachander, Dipika, Shivashankara, Arnadi, Vidyasagar, Mamidipudi, Tonse, Raees, Pais, Sarita, Lobo, Ashwin, Hegde, Sanath, Rao, Suresh, Baliga, Manjeshwar. Salivary Parameters as Predictive Markers for Radiation-induced Treatment Response in Head and Neck Cancers: An Investigational Study. سامانه مدیریت نشریات علمی, 1397; 9(2): 133-142. doi: 10.30476/mejc.2018.42115

Salivary Parameters as Predictive Markers for Radiation-induced Treatment Response in Head and Neck Cancers: An Investigational Study

Middle East Journal of Cancer
مقاله 8، دوره 9، شماره 2، تیر 2018، صفحه 133-142    اصل مقاله (1.6 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2018.42115
نویسندگان
Dipika Jayachander1؛ Arnadi Ramachandrayya Shivashankara2؛ Mamidipudi Srinivasa Vidyasagar3؛ Raees Tonse4؛ Sarita Pais5؛ Ashwin DL Lobo2؛ Sanath Kumar Hegde6؛ Suresh Rao6؛ Manjeshwar Shrinath Baliga* 6
1Department of Radiation Oncology, Apollo Hospital, Bengaluru, Karnataka, India
2Department of Biochemistry, Father Miller Medical College, Kankanady, Mangalore, India
3Department of Radiotherapy, Kasturba Medical College, Manipal University, Manipal, Karnataka, India
4Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India
5Department of Radiation Oncology, Narayana Hrudayalaya, Bengaluru, Karnataka, India
6Department of Radiation Oncology, Mangalore Institute of Oncology, Pumpwell, Mangalore, Karnataka, India
چکیده
Background: This study evaluates the predictive significance of salivary amylase, glutathione, lipid peroxides, and lactate dehydrogenase in the treatment of head and neck cancer patients who undergo curative radiotherapy/chemoradiotherapy.Methods: The volunteers for the study included head and neck cancer patients that required curative radiotherapy/chemoradiotherapy. Patients provided saliva and blood samples before the start of radiation treatment and 24 h after the first radiation fraction of 2 Gy (before the start of the second fraction). Samples were assessed for the levels of blood and salivary amylase, glutathione, lipid peroxides, and lactate dehydrogenase by standard laboratory methods. Clinical tumor radioresponse was assessed one month after the completion of treatment as complete responders, partial responders, and nonresponders.Results: The results indicated a significant increase in the levels of amylase, lactate dehydrogenase, and lipid peroxides; and a concomitant decrease in the levels of glutathione P
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