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Dehghan Manshadi, Zahra, Hamid, Mohammad, Kosari, Farid, Tayebinia, Heidar, Khodadadi, Iraj. (1397). The Relationship between Matrix Metalloproteinase Gene Polymorphisms and Tumor Type, Tumor Size, and Metastasis in Women with Breast Cancer in Central Iran. سامانه مدیریت نشریات علمی, 9(2), 123-131. doi: 10.30476/mejc.2018.42114
Zahra Dehghan Manshadi; Mohammad Hamid; Farid Kosari; Heidar Tayebinia; Iraj Khodadadi. "The Relationship between Matrix Metalloproteinase Gene Polymorphisms and Tumor Type, Tumor Size, and Metastasis in Women with Breast Cancer in Central Iran". سامانه مدیریت نشریات علمی, 9, 2, 1397, 123-131. doi: 10.30476/mejc.2018.42114
Dehghan Manshadi, Zahra, Hamid, Mohammad, Kosari, Farid, Tayebinia, Heidar, Khodadadi, Iraj. (1397). 'The Relationship between Matrix Metalloproteinase Gene Polymorphisms and Tumor Type, Tumor Size, and Metastasis in Women with Breast Cancer in Central Iran', سامانه مدیریت نشریات علمی, 9(2), pp. 123-131. doi: 10.30476/mejc.2018.42114
Dehghan Manshadi, Zahra, Hamid, Mohammad, Kosari, Farid, Tayebinia, Heidar, Khodadadi, Iraj. The Relationship between Matrix Metalloproteinase Gene Polymorphisms and Tumor Type, Tumor Size, and Metastasis in Women with Breast Cancer in Central Iran. سامانه مدیریت نشریات علمی, 1397; 9(2): 123-131. doi: 10.30476/mejc.2018.42114

The Relationship between Matrix Metalloproteinase Gene Polymorphisms and Tumor Type, Tumor Size, and Metastasis in Women with Breast Cancer in Central Iran

Middle East Journal of Cancer
مقاله 7، دوره 9، شماره 2، تیر 2018، صفحه 123-131    اصل مقاله (177.48 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2018.42114
نویسندگان
Zahra Dehghan Manshadi1؛ Mohammad Hamid2؛ Farid Kosari3؛ Heidar Tayebinia1؛ Iraj Khodadadi* 1
1Department of Clinical Biochemistry, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
2Department of Molecular Medicine, Pasteur Institute of Iran, Tehran, Iran
3Pathology Laboratory, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Background: Matrix metalloproteinases-2 and -9 play important roles in the development of breast cancer by hydrolyzing the extracellular matrix. Since −1306C/T and −1562C/T polymorphisms are located at the promoter regions of the matrix metalloproteinase- 2 and -9 genes, respectively, C to T substitution may affect promoter activity and impact the rate of extracellular matrix degradation and cancerous cell proliferation. Therefore, we aimed to determine the genotype and allele frequencies of these polymorphisms in Iranian healthy women and women with breast cancer. We have also examined the correlation of genotypes with clinicopathological parameters such as tumor type, tumor size, and metastasis to lymph nodes.Methods: This case-control study enrolled 200 women with breast cancer and 200 age-matched healthy women. DNA was extracted, and we determined the genotype and allele frequencies of −1306C/T matrix metalloproteinase-2 and −1562C/T matrix metalloproteinase-9 polymorphisms by the polymerase chain reaction-restriction fragment length polymorphism method. Additionally, tumor size (20 mm), tumor type (ductal/non-ductal), and metastasis (yes/no) were determined.Results: Genotype and allele frequencies of the −1306C/T matrix metalloproteinase- 2 polymorphism showed no significant association with the occurrence of breast cancer. Genotype and allele distribution differed in the −1562C/T matrix metalloproteinase- 9 polymorphism and indicated a 4.83-fold increase in the risk of breast cancer for T allele carriers. There was no likelihood of any interaction found between the two polymorphisms and susceptibility to breast cancer. In addition, the −1562C/T matrix metalloproteinase-9 T allele showed an association with metastasis to lymph nodes but we observed no association between the −1306C/T matrix metalloproteinase- 2 polymorphism and clinicopathological features.Conclusion: The ‒1562C/T matrix metalloproteinase-9 polymorphism is involved in the pathogenesis of breast cancer in Iranian women. The T allele may increase the risk of disease.
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