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| تعداد دریافت فایل اصل مقاله | 7,451,575 |
Tumor Infiltrating Lymphocytes in Different Stages of Malignant Melanoma and Correlation with Tumor Stage and Other Prognostic Factors: A Retrospective Multicenter Study | ||
| Middle East Journal of Cancer | ||
| مقاله 5، دوره 8، شماره 4، دی 2017، صفحه 207-212 اصل مقاله (4.77 M) | ||
| نوع مقاله: Original Article(s) | ||
| نویسندگان | ||
| Alireza Ghanadan* 1، 2، 3؛ Amir-Hoshang Ehsani4؛ Ali-Mohammad Farahmand1؛ Mojtaba Mirzaei1 | ||
| 1Department of Dermatopathology, Razi Dermatology Hospital, Tehran University of Medical Sciences, Tehran, Iran | ||
| 2Department of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran | ||
| 3Universal Scientific Education and Research Network (USERN), Tehran, Iran | ||
| 4Autoimmune Bullous Diseases Research Center, Department of Dermatology, Razi Dermatology Hospital, Tehran University of Medical Sciences, Tehran, Iran | ||
| چکیده | ||
| Background: Melanoma is one of the most immunogenic tumors that causes a significant immune response. Tumor infiltrating lymphocytes are an important part of this response. Tumor infiltrating lymphocytes are lymphocytes in close association with tumor cells that have infiltrated tumor nests. In this study, we attempt to evaluate the relationship of tumor infiltrating lymphocytes in malignant melanoma with histopathologic findings, tumor stage, and other prognostic factors. Method: This was a retrospective cross-sectional study. We re-evaluated patients’ specimens and categorized the tumor infiltrating lymphocytes as grades 0, 1, 2, or 3 based on density and distribution of the infiltrating lymphocytes. Results: We enrolled 111 patients with a mean age of 59.33±14.68 years, and a male to female ratio of 1.09. There was no evidence of tumor infiltrating lymphocytes in 17.1% of patients. The melanoma subtypes had the following tumor infiltrating lymphocyte grades: 1 (47.7%), 2 (28.8%), and 3 (6.3%). Cancer stage significantly decreased with increasing grade of tumor infiltrating lymphocyte (P<0.001). Although numerous histopathologic findings had a relationship with tumor infiltrating lymphocytes, only microsatellitosis had a significant relation after adjustments for melanoma stage (P< 0.001). Conclusion: Increased density of tumor infiltrating lymphocytes can show a more effective immune response against melanoma. This response can limit cancer progression and result in tumor diagnosis at lower stages of the disease. | ||
| کلیدواژهها | ||
| Melanoma؛ Tumor infiltrating lymphocytes؛ Tumor stage؛ Immune response؛ Prognostic factor | ||
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آمار تعداد مشاهده مقاله: 2,496 تعداد دریافت فایل اصل مقاله: 843 |
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