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Alavi, Mehrossadat, Zal, Fatemeh, Zamani, Fahimeh, Kazemi, Mehdi, Rasti, Mozhgan. (1396). Evaluation of a Number of Blood Biochemical Markers after Radioiodine Therapy in Papillary Thyroid Cancer Patients. سامانه مدیریت نشریات علمی, 8(2), 77-82.
Mehrossadat Alavi; Fatemeh Zal; Fahimeh Zamani; Mehdi Kazemi; Mozhgan Rasti. "Evaluation of a Number of Blood Biochemical Markers after Radioiodine Therapy in Papillary Thyroid Cancer Patients". سامانه مدیریت نشریات علمی, 8, 2, 1396, 77-82.
Alavi, Mehrossadat, Zal, Fatemeh, Zamani, Fahimeh, Kazemi, Mehdi, Rasti, Mozhgan. (1396). 'Evaluation of a Number of Blood Biochemical Markers after Radioiodine Therapy in Papillary Thyroid Cancer Patients', سامانه مدیریت نشریات علمی, 8(2), pp. 77-82.
Alavi, Mehrossadat, Zal, Fatemeh, Zamani, Fahimeh, Kazemi, Mehdi, Rasti, Mozhgan. Evaluation of a Number of Blood Biochemical Markers after Radioiodine Therapy in Papillary Thyroid Cancer Patients. سامانه مدیریت نشریات علمی, 1396; 8(2): 77-82.

Evaluation of a Number of Blood Biochemical Markers after Radioiodine Therapy in Papillary Thyroid Cancer Patients

Middle East Journal of Cancer
مقاله 3، دوره 8، شماره 2، تیر 2017، صفحه 77-82    اصل مقاله (138.41 K)
نوع مقاله: Original Article(s)
نویسندگان
Mehrossadat Alavi1، 2؛ Fatemeh Zal3، 4؛ Fahimeh Zamani3؛ Mehdi Kazemi2؛ Mozhgan Rasti* 3
1Medical Imaging Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2Nuclear Medicine Department, Shiraz University of Medical Sciences, Shiraz, Iran
3Biochemistry Department, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran
4Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: This study aimed to assess several biochemical and oxidative stress parameters before and after radioiodine therapy in patients with well-differentiated thyroid cancer who consumed a low iodine diet and withdrawal of levothyroxine after total thyroidectomy.Methods: We enrolled 40 candidates for radioiodine therapy. Blood sampling was performed prior to as well as 72 h after consumption of 125-200 mCi of 131I. Total protein, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and creatinine were measured. Oxidative stress parameters that included malondialdehyde and protein carbonyl levels were also assessed.Results: There were significantly decreased total protein, creatinine, aspartate aminotransferase, and alanine aminotransferase levels (P<0.001) after treatment. However, malondialdehyde levels increased significantly (P<0.05) over the studied time.Conclusion: We found that radioactive iodine absorption in peripheral tissues due to a low-iodine diet and levothyroxine withdrawal could relieve iodine deficiency in the liver and kidneys which resulted in reduced total protein, aspartate aminotransferase, alanine aminotransferase, and creatinine levels. However, it induced oxidative stress by increasing malondialdehyde levels in the blood.
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