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Oum Kaltoum, Ait Boujmia, Sellama, Nadifi, Hind, Dehbi, Yaya, Kassogue, Mouna, Lamchahab, Asma, Quessar. (1395). Association of Glutathione S-transferase Genes (M1 and T1) with the Risk of Acute Myeloid Leukemia in a Moroccan Population. سامانه مدیریت نشریات علمی, 8(1), 7-12.
Ait Boujmia Oum Kaltoum; Nadifi Sellama; Dehbi Hind; Kassogue Yaya; Lamchahab Mouna; Quessar Asma. "Association of Glutathione S-transferase Genes (M1 and T1) with the Risk of Acute Myeloid Leukemia in a Moroccan Population". سامانه مدیریت نشریات علمی, 8, 1, 1395, 7-12.
Oum Kaltoum, Ait Boujmia, Sellama, Nadifi, Hind, Dehbi, Yaya, Kassogue, Mouna, Lamchahab, Asma, Quessar. (1395). 'Association of Glutathione S-transferase Genes (M1 and T1) with the Risk of Acute Myeloid Leukemia in a Moroccan Population', سامانه مدیریت نشریات علمی, 8(1), pp. 7-12.
Oum Kaltoum, Ait Boujmia, Sellama, Nadifi, Hind, Dehbi, Yaya, Kassogue, Mouna, Lamchahab, Asma, Quessar. Association of Glutathione S-transferase Genes (M1 and T1) with the Risk of Acute Myeloid Leukemia in a Moroccan Population. سامانه مدیریت نشریات علمی, 1395; 8(1): 7-12.

Association of Glutathione S-transferase Genes (M1 and T1) with the Risk of Acute Myeloid Leukemia in a Moroccan Population

Middle East Journal of Cancer
مقاله 2، دوره 8، شماره 1، فروردین 2017، صفحه 7-12    اصل مقاله (263.86 K)
نوع مقاله: Original Article(s)
نویسندگان
Ait Boujmia Oum Kaltoum* 1؛ Nadifi Sellama1؛ Dehbi Hind1؛ Kassogue Yaya1؛ Lamchahab Mouna2؛ Quessar Asma2
1Laboratory of Genetics and Molecular Pathology, Medical School, University Hassan II, Casablanca, Morocco
2Department of Onco-Hematology, Ibn Rochd University Hospital, Casablanca, Morocco
چکیده
Background: Acute myeloid leukemia, as most cancers, results from exposure to carcinogens and an impaired inherited individual capacity to eliminate xenobiotics. The present case-control study measures the relationship between glutathione S-transferase (GST) T1 and M1 null genotypes and the risk of acute myeloid leukemia.Methods: We identified the GSTT1 andGSTM1 genotypes by multiplex polymerase chain reaction in 129 acute myeloid leukemia patients and 129 controls.Results: Individuals that carried GSTT1 null had a risk of acute myeloid leukemia when compared to GSTT1 present carriers (OR: 2.80; 95% CI: 1.63-4.80, P=0.00036). However, GSTM1 null did not influence the risk for acute myeloid leukemia (OR: 1.20; 95% CI: 0.72-1.97, P=0.53). The combined GSTT1 null/GSTM1 present genotype showed an association with the risk for acute myeloid leukemia compared to those that carried both functional genotypes (OR: 8.85; 95% CI: 3.09-23.8, P=0.0001). The double null genotype also showed an association with the risk for acute myeloid leukemia (OR: 2.32, 95% CI: 1.15-4.66, P=0.019).Conclusion: Both GSTT1 null and GST double-null genotypes may be risk factors for acute myeloid leukemia. Further studies are needed to confirm these results.
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