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Treatment of Hormone Resistance with Docetaxel in Metastatic Prostate Cancer Patients: Results of a Clinical Experience at Omid Hospital, Isfahan, Iran | ||
| Middle East Journal of Cancer | ||
| مقاله 1، دوره 8، شماره 1، فروردین 2017، صفحه 1-6 اصل مقاله (285.25 K) | ||
| نوع مقاله: Original Article(s) | ||
| نویسندگان | ||
| Mina Tajvidi؛ Mahnaz Roayaei؛ Simin Hematti؛ Hadi Faezi* | ||
| Department of Radiation Oncology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran | ||
| چکیده | ||
| Background: Metastatic prostate cancer is one of the most important cancers among men worldwide. Androgen ablation therapy can be used in treatment of these patients; however, most will progress to metastatic hormone-refractory prostate cancer. In this regard, docetaxel has been approved to treat metastatic hormone-refractory prostate cancer in the United States. In this study, we aimed to investigate the results of this treatment modality in metastatic prostate cancer patients from Iran.Methods:We evaluated PSA response and bone pain relief in 18 metastatic prostate cancer patients who underwent treatment with docetaxel at a dose of 75 mg/m2 intravenously on the first day of treatment. The treatment was repeated every three weeks (6 cycles) along with 10 mg of prednisolone.Results: Of 18 patients, 39% had >50% decline in PSA levels.There were 16% of the patients with a PSA decline of approximately 30% to 50% of the pre-treatment levels. In addition, 29% of the patients had progressive PSA levels during chemotherapy. Among them, 55% had significant pain relief.Conclusion: This research showed the effectiveness of docetaxel to decrease PSA levels in metastatic hormone-refractory prostate cancer patients from Iran. Docetaxel was also valuable in alleviation of pain in these patients. However, prospective studies should validate this approach. | ||
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