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Sari Aslani, Fatemeh, Momeni, Azarmidokht, Momtahan, Mozhdeh, Akbarzadeh Jahromi, Mozhgan, Dehghanian, Amir Reza, Motevali, Dorna. (1394). Evaluation of p53, PTEN and β-catenin Immunoexpressions in Primary Ovarian Epithelial Tumors. سامانه مدیریت نشریات علمی, 6(3), 135-142.
Fatemeh Sari Aslani; Azarmidokht Momeni; Mozhdeh Momtahan; Mozhgan Akbarzadeh Jahromi; Amir Reza Dehghanian; Dorna Motevali. "Evaluation of p53, PTEN and β-catenin Immunoexpressions in Primary Ovarian Epithelial Tumors". سامانه مدیریت نشریات علمی, 6, 3, 1394, 135-142.
Sari Aslani, Fatemeh, Momeni, Azarmidokht, Momtahan, Mozhdeh, Akbarzadeh Jahromi, Mozhgan, Dehghanian, Amir Reza, Motevali, Dorna. (1394). 'Evaluation of p53, PTEN and β-catenin Immunoexpressions in Primary Ovarian Epithelial Tumors', سامانه مدیریت نشریات علمی, 6(3), pp. 135-142.
Sari Aslani, Fatemeh, Momeni, Azarmidokht, Momtahan, Mozhdeh, Akbarzadeh Jahromi, Mozhgan, Dehghanian, Amir Reza, Motevali, Dorna. Evaluation of p53, PTEN and β-catenin Immunoexpressions in Primary Ovarian Epithelial Tumors. سامانه مدیریت نشریات علمی, 1394; 6(3): 135-142.

Evaluation of p53, PTEN and β-catenin Immunoexpressions in Primary Ovarian Epithelial Tumors

Middle East Journal of Cancer
مقاله 1، دوره 6، شماره 3، مهر 2015، صفحه 135-142    اصل مقاله (2.21 M)
نوع مقاله: Original Article(s)
نویسندگان
Fatemeh Sari Aslani* 1؛ Azarmidokht Momeni1؛ Mozhdeh Momtahan2؛ Mozhgan Akbarzadeh Jahromi1؛ Amir Reza Dehghanian1؛ Dorna Motevali1
1Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Ovarian cancer comprises a heterogeneous group of neoplasms. The prognosis cannot be predicted by histopathologic examination alone. The aim of this study is to evaluate p53, PTEN, and β-catenin expressions in primary ovarian carcinomas in an attempt to find a possible relationship with morphologic parameters and clinical findings.Methods: The study included 100 epithelial ovarian tumors (borderline and carcinomas) from affiliated hospitals of Shiraz university of medical sciences during 2007-2013. Immunohistochemical staining for p53, PTEN, and β-catenin was performed on 65 serous, 18 mucinous, 10 endometrioid, 5 clear cell, and 2 mixed tumors.Results: p53 expression pattern in serous carcinoma significantly differed from endometrioid carcinomas. Strong positivity (2+) in >50% of the tumor cells favored serous carcinoma. PTEN expression significantly differed in mucinous and serous carcinomas as well as in endometrioid carcinoma and borderline endometrioid tumor. There was significantly decreased β-catenin expression in the carcinomas compared with borderline tumors. In all of the different subtypes of ovarian carcinomas, we observed a significant association with decreased β-catenin expression to tumor grade as well as in serous carcinomas with increased nuclear grade, mitosis, and tumor grade. There was no significant relation between expressions of p53, PTEN, and β-catenin in epithelial ovarian tumors to FIGO staging, response to chemotherapy, serum CA- 125 marker, and tumor recurrence.Conclusion: p53 and PTEN are helpful in differentiation of some epithelial ovarian tumor subtypes. In serous carcinomas, diminished expression of β-catenin is associated with higher tumor and nuclear grade. This expression is significantly different in borderline and carcinomas.
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