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Abd El Moneim, Nadia, Masry, Hisham, Sorial, Mina, Hewala, Taha, Embaby, Amira, Sheweita, Salah. (1393). A Molecular Case-Control Study on the Association of Melatonin Hormone and rs#10830963 Single Nucleotide Polymorphism in its Receptor MTNR1B Gene with Breast Cancer. سامانه مدیریت نشریات علمی, 6(1), 11-20.
Nadia A Abd El Moneim; Hisham El Masry; Mina Mamdouh Sorial; Taha I Hewala; Amira Embaby; Salah Sheweita. "A Molecular Case-Control Study on the Association of Melatonin Hormone and rs#10830963 Single Nucleotide Polymorphism in its Receptor MTNR1B Gene with Breast Cancer". سامانه مدیریت نشریات علمی, 6, 1, 1393, 11-20.
Abd El Moneim, Nadia, Masry, Hisham, Sorial, Mina, Hewala, Taha, Embaby, Amira, Sheweita, Salah. (1393). 'A Molecular Case-Control Study on the Association of Melatonin Hormone and rs#10830963 Single Nucleotide Polymorphism in its Receptor MTNR1B Gene with Breast Cancer', سامانه مدیریت نشریات علمی, 6(1), pp. 11-20.
Abd El Moneim, Nadia, Masry, Hisham, Sorial, Mina, Hewala, Taha, Embaby, Amira, Sheweita, Salah. A Molecular Case-Control Study on the Association of Melatonin Hormone and rs#10830963 Single Nucleotide Polymorphism in its Receptor MTNR1B Gene with Breast Cancer. سامانه مدیریت نشریات علمی, 1393; 6(1): 11-20.

A Molecular Case-Control Study on the Association of Melatonin Hormone and rs#10830963 Single Nucleotide Polymorphism in its Receptor MTNR1B Gene with Breast Cancer

Middle East Journal of Cancer
مقاله 2، دوره 6، شماره 1، فروردین 2015، صفحه 11-20    اصل مقاله (668.55 K)
نوع مقاله: Original Article(s)
نویسندگان
Nadia A Abd El Moneim1؛ Hisham El Masry2؛ Mina Mamdouh Sorial2؛ Taha I Hewala* 3؛ Amira Embaby2؛ Salah Sheweita2
1Department of Cancer Management and Research, Medical Research Institute, University of Alexandria, Alexandria, Egypt
2Department of Biotechnology, Institute of Graduate Studies and Research, University of Alexandria, Alexandria, Egypt
3Radiation Science Department, Medical Research Institute, University of Alexandria, Alexandria, Egypt
چکیده
Background: The main function of the pineal hormone melatonin which is mediated via its two receptors, MTNR1A and MTNR1B, is to mediate dark signals in addition to anti-oxidation, immune system enhancement, protection from radiation, and anti-cancer functions. A common single nucleotide polymorphism in the MTNR1B gene is rs#10830963, which is well known as a risk factor for type 2 diabetes mellitus. This study intends to figure out the role of melatonin and its receptor MTNR1B gene rs#10830963 polymorphism in breast cancer incidence, diagnosis and prognosis.Methods: This study included 43 females with breast cancer and 45 apparently normal healthy females. Restriction fragment length polymorphism-PCR was used for amplification and genotyping of the MTNR1B gene rs#10830963 polymorphism in whole blood. Serum melatonin levels were measured using a ready-for-use radioimmunoassay kit. Results: For the MTNR1B gene rs#10830963 polymorphism, we observed a significantly higher GG genotype frequency among cases (72.1%) than controls (13.3%), with a diagnostic sensitivity of 83.78% and specificity of 76.47%. The cases had a frequency of 11.6% for the CC genotype and 16.3% for the CG genotype which was significantly lower compared to controls that had a 44.4% frequency of the CC genotype and 42.2% frequency of the CG genotype. The GG genotype had a significant association with larger tumor volume (P=0.048). Serum melatonin levels were significantly lower among breast cancer patients than controls. Using the ROC curve analysis, serum melatonin showed a significant AUC (72.6%, P39.5 pg/ml.Conclusion: The risk for breast cancer incidence increased as the serum levels of melatonin decreased and in females homozygous for the G allele (GG genotype) of the MTNR1B gene rs#10830963 polymorphism. The GG genotype was found to be associated with increased breast tumor volume as a marker of a poor prognosis breast cancer.
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