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Andisheh Tadbir, Azadeh, Fattahi, Mohmmad Javad, Khademi, Bijan, Pourshahidi, Sara, Ebrahimi, Hooman, Sardari, Yasaman, Fattah, Zahra. (1389). Serum Level of Galectin-3 in Patients with Oral Squamous Cell Carcinoma. سامانه مدیریت نشریات علمی, 1(2), 77-81.
Azadeh Andisheh Tadbir; Mohmmad Javad Fattahi; Bijan Khademi; Sara Pourshahidi; Hooman Ebrahimi; Yasaman Sardari; Zahra Fattah. "Serum Level of Galectin-3 in Patients with Oral Squamous Cell Carcinoma". سامانه مدیریت نشریات علمی, 1, 2, 1389, 77-81.
Andisheh Tadbir, Azadeh, Fattahi, Mohmmad Javad, Khademi, Bijan, Pourshahidi, Sara, Ebrahimi, Hooman, Sardari, Yasaman, Fattah, Zahra. (1389). 'Serum Level of Galectin-3 in Patients with Oral Squamous Cell Carcinoma', سامانه مدیریت نشریات علمی, 1(2), pp. 77-81.
Andisheh Tadbir, Azadeh, Fattahi, Mohmmad Javad, Khademi, Bijan, Pourshahidi, Sara, Ebrahimi, Hooman, Sardari, Yasaman, Fattah, Zahra. Serum Level of Galectin-3 in Patients with Oral Squamous Cell Carcinoma. سامانه مدیریت نشریات علمی, 1389; 1(2): 77-81.

Serum Level of Galectin-3 in Patients with Oral Squamous Cell Carcinoma

Middle East Journal of Cancer
مقاله 4، دوره 1، شماره 2، تیر 2010، صفحه 77-81    اصل مقاله (43.93 K)
نوع مقاله: Original Article(s)
نویسندگان
Azadeh Andisheh Tadbir* 1؛ Mohmmad Javad Fattahi2؛ Bijan Khademi3؛ Sara Pourshahidi4؛ Hooman Ebrahimi4؛ Yasaman Sardari1؛ Zahra Fattah5
1Department of Oral Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
2Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran
3Department of Otolaryngology, Shiraz University of Medical Sciences, Shiraz, Iran
4Department of Oral Medicine, School of Dentistry, Shiraz University of Medical Sciences,Shiraz, Iran
5School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Introduction: Galectin-3, a member of the family of β-galactoside-binding animal lectins, has been implicated in tumor invasion and metastasis.Materials and Methods: Using an ELISAkit, we assessed the circulating levels of galectin-3 in sera from 40 oral squamous cell carcinoma (OSCC) patients and from 43 healthy controls.Results: Serum galectin-3 levels in OSCC patients were significantly higher (5.1±2.5 ng/ml) when compared with healthy controls (2.6±3.07 ng/ml, P<0.0005). There was no apparent correlation between serum galectin-3 concentration and clinico-pathological features such as stage, tumor size, nodal status, distant metastasis and histological grade.Conclusion: This result suggests that, in addition to other tests, measurement of serum galectin-3 concentrations can be utilized as an adjuvant test for establishing a diagnosis of OSCC.
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