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Mojtahedi, Zahra, Solati Dalaki, Sharareh, Samsami Dehaghani, Alamtaj, Robati, Minoo, Monabati, Ahmad, Fattahi, Mohammad Javad, Ghaderi, Abbas. (1389). Serum HER2 Level in Epithelial Ovarian Cancer. سامانه مدیریت نشریات علمی, 1(2), 65-68.
Zahra Mojtahedi; Sharareh Solati Dalaki; Alamtaj Samsami Dehaghani; Minoo Robati; Ahmad Monabati; Mohammad Javad Fattahi; Abbas Ghaderi. "Serum HER2 Level in Epithelial Ovarian Cancer". سامانه مدیریت نشریات علمی, 1, 2, 1389, 65-68.
Mojtahedi, Zahra, Solati Dalaki, Sharareh, Samsami Dehaghani, Alamtaj, Robati, Minoo, Monabati, Ahmad, Fattahi, Mohammad Javad, Ghaderi, Abbas. (1389). 'Serum HER2 Level in Epithelial Ovarian Cancer', سامانه مدیریت نشریات علمی, 1(2), pp. 65-68.
Mojtahedi, Zahra, Solati Dalaki, Sharareh, Samsami Dehaghani, Alamtaj, Robati, Minoo, Monabati, Ahmad, Fattahi, Mohammad Javad, Ghaderi, Abbas. Serum HER2 Level in Epithelial Ovarian Cancer. سامانه مدیریت نشریات علمی, 1389; 1(2): 65-68.

Serum HER2 Level in Epithelial Ovarian Cancer

Middle East Journal of Cancer
مقاله 2، دوره 1، شماره 2، تیر 2010، صفحه 65-68    اصل مقاله (36.03 K)
نوع مقاله: Original Article(s)
نویسندگان
Zahra Mojtahedi1؛ Sharareh Solati Dalaki2؛ Alamtaj Samsami Dehaghani2؛ Minoo Robati2؛ Ahmad Monabati3؛ Mohammad Javad Fattahi1؛ Abbas Ghaderi* 4
1Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran
3Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran
4Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Introduction: The proto-oncogene HER2 plays a key role in the control of cellular proliferation. Its overexpression has been reported to be associated with a poor prognosis in cancer, particularly in breast cancer.Materials and Methods: In the present study, serum HER2 levels were investigated in patients diagnosed with epithelial ovarian cancer. Serum HER2 levels were detected by an ELISA commercial kit in 51 patients and 33 healthy individuals.Results: The mean serum HER2 level was found to be significantly higher in patients than healthy controls (P=0.005). In 29% of patients, serum HER2 levels were higher than the cut-off value. HER2 serum level was not associated with tumor stage at diagnosis.Conclusion: Elevation of HER2 in a high proportion of patients with epithelial ovarian cancer further strengthens the importance of this molecule in the pathogenesis of ovarian cancer.
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