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Matsuyama, Koki, Ota, Takeshi, Baba, Junko, Miyabayashi, Takao, Watanabe, Satoshi, Kagamu, Hiroshi, Narita, Ichiei, Nakata, Koh, Yoshizawa, Hirohisa. (1389). Eradication of Established Murine Skin Tumors by Cyclic Chemoimmunotherapy with Cyclophosphamide and Effector T Cells. سامانه مدیریت نشریات علمی, 2(1), 9-18.
Koki Matsuyama; Takeshi Ota; Junko Baba; Takao Miyabayashi; Satoshi Watanabe; Hiroshi Kagamu; Ichiei Narita; Koh Nakata; Hirohisa Yoshizawa. "Eradication of Established Murine Skin Tumors by Cyclic Chemoimmunotherapy with Cyclophosphamide and Effector T Cells". سامانه مدیریت نشریات علمی, 2, 1, 1389, 9-18.
Matsuyama, Koki, Ota, Takeshi, Baba, Junko, Miyabayashi, Takao, Watanabe, Satoshi, Kagamu, Hiroshi, Narita, Ichiei, Nakata, Koh, Yoshizawa, Hirohisa. (1389). 'Eradication of Established Murine Skin Tumors by Cyclic Chemoimmunotherapy with Cyclophosphamide and Effector T Cells', سامانه مدیریت نشریات علمی, 2(1), pp. 9-18.
Matsuyama, Koki, Ota, Takeshi, Baba, Junko, Miyabayashi, Takao, Watanabe, Satoshi, Kagamu, Hiroshi, Narita, Ichiei, Nakata, Koh, Yoshizawa, Hirohisa. Eradication of Established Murine Skin Tumors by Cyclic Chemoimmunotherapy with Cyclophosphamide and Effector T Cells. سامانه مدیریت نشریات علمی, 1389; 2(1): 9-18.

Eradication of Established Murine Skin Tumors by Cyclic Chemoimmunotherapy with Cyclophosphamide and Effector T Cells

Middle East Journal of Cancer
مقاله 3، دوره 2، شماره 1، فروردین 2011، صفحه 9-18    اصل مقاله (598.8 K)
نوع مقاله: Original Article(s)
نویسندگان
Koki Matsuyama* 1؛ Takeshi Ota1؛ Junko Baba1؛ Takao Miyabayashi1؛ Satoshi Watanabe1؛ Hiroshi Kagamu1؛ Ichiei Narita1؛ Koh Nakata2؛ Hirohisa Yoshizawa2
1Division of Respiratory Medicine, Department of Homeostatic Regulation and Development, Niigata University, Niigata, Japan
2Bioscience Medical Research Center, Niigata University Medical and Dental Hospital, Niigata, Japan
چکیده
Background: Nonmyeloablative chemotherapy followed by adoptive immunotherapy is an attractive strategy for depleting regulatory T cells in the host. However, its efficacy is transient. Here, we aim to investigate whether cyclic chemoim- munotherapy has therapeutic efficacy against cancer.Methods:We examined the efficacy of cyclic chemoimmunotherapy with cyclophos- phamide and adoptively transferred effector T cells against 5-day, established MCA205 murine skin sarcomas.Results: Cyclophosphamide administration followed by adoptive immunotherapy augmented the trafficking of effector T cells into established tumors. Further, multiple cyclophosphamide administrations helped effector T cells to persist at the sites. Chemoimmunotherapy achieved complete tumor regression even with the transfer of a limited number of effector T cells (5×106).Conclusion: Cyclic chemoimmunotherapy, which maintains adoptively transferred T cells by impairing regulatory T cells, is a potentially suitable treatment for established tumors.
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