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Survival Analysis in Patients with Non- metastatic Squamous Cell Carcinoma of the Urinary Bladder | ||
| Middle East Journal of Cancer | ||
| مقاله 3، دوره 2، شماره 2، تیر 2011، صفحه 59-64 اصل مقاله (229.52 K) | ||
| نوع مقاله: Original Article(s) | ||
| نویسندگان | ||
| Mohamed I. El-Sayed* 1؛ Ahmed M. Abdel-Rahim2 | ||
| 1Radiation Therapy Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt | ||
| 2Urology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt | ||
| چکیده | ||
| Background: We conducted a retrospective analysis to evaluate overall survival (OAS) and disease free survival (DFS) rates in patients with squamous cell carcinoma of the urinary bladder according to different prognostic factors.Methods: This retrospective study analyzed the medical records of patients with non-metastatic squamous cell carcinoma of the urinary bladder. All men underwent radical cystectomy and women underwent anterior pelvic exentration. Most patients had postoperative radiation therapy. The log-rank test examined differences in OAS and DFS rates.Results: The medical records of 106 patients were analyzed. The median follow- up from the date of enrollment was 30 months and ranged from 2 to 73 months. For the entire group, three-year OAS rates were 46.9% and DFS rates were 44%. For patients with P2 (tumor invasion into the muscularis propria) the three-year OAS rate was 53%, for P3 (tumor invasion into perivesical fat) it was 45% and 9% for P4 (tumor invasion into adjacent organs, pelvic wall or abdominal wall) The OAS rate was statistically significant in favor of P2 disease (P=0.0041). The three-year DFS rate was 50% for P2, 45% for P3 and 9% for P4 disease (P=0.0125). Administration of post-operative radiotherapy did not result in statistically significant improvement in three-year OAS and DFS rates.Conclusion: Survival rates were statistically significant and higher in patients with P2 and P3 disease compared to P4 disease. Adjuvant radiotherapy did not result in statistically significant survival improvement | ||
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